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Modulation of viral neuroinflammation by astrocytic RIPK3 and serine protease inhibitors
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).ORCID iD: 0000-0001-8512-0535
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).ORCID iD: 0000-0001-6553-0940
2025 (English)In: TINS - Trends in Neurosciences, ISSN 0166-2236, E-ISSN 1878-108XArticle in journal (Refereed) In press
Abstract [en]

A recent study byLindman and colleagueshighlights a cell type-specific function of receptor-interacting kinase 3 (RIPK3) in astrocytes during neurotropic flavivirus infection. Despite a proinflammatory transcriptional profile, RIPK3 in astrocytes can attenuate neuroinflammation and reduce leucocyte infiltration through upregulation of Serpin clade A member 3N (SerpinA3N), protecting mice from excessive neuroinflammation and increasing overall survival.
Place, publisher, year, edition, pages
Cell Press, 2025.
Keywords [en]
BBB, flavivirus, leukocyte infiltration, neuroimmune interactions, neurons, T cells
National Category
Microbiology in the Medical Area
Identifiers
URN: urn:nbn:se:umu:diva-245600DOI: 10.1016/j.tins.2025.09.012Scopus ID: 2-s2.0-105018101434OAI: oai:DiVA.org:umu-245600DiVA, id: diva2:2007115
Available from: 2025-10-17 Created: 2025-10-17 Last updated: 2025-10-17

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Rosendal, EbbaÖverby, Anna K.

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