Semi-volatile organic substances (SVOCs) including flame retardants and plasticizers may emit from products during their life cycle and pose health risks, such as endocrine disruption and neurodevelopmental effects. Cars, as enclosed spaces with SVOC-emitting materials, can contribute significantly to human exposure, especially for toddlers and professional drivers who may have higher risk. This study assessed exposure to a selection of SVOCs in car cabins for various scenarios, considering car cabin temperatures (25 °C or 60 °C), user physiology (adult/toddler), and time spent in cars (average user/professional driver). Scenarios included cooling dynamics in warm cars, assuming ventilation reduces cabin temperature from 60 °C to 25 °C within 5 min. The highest total exposure dose was estimated for di-(2-propylheptyl) phthalate (DPHP) and tris(1,3-dichloroisopropyl) phosphate (TDCIPP). Inhalation and air-to-skin contact were the dominant exposure routes for compounds like 2,2′-methylenebis (4-methyl-6-tert-butylphenol) (MBMBP), while ingestion of dust was significant for others like TDCIPP. Data collected from the literature on levels of SVOCs in private houses, offices and childcare facilities facilitated estimation of the contribution of cars to the total dose obtained throughout the day. Although toddlers and professional drivers had similar estimated exposure doses, despite differing times spent in cars, a first-tier risk assessment showed no immediate health concerns, with hazard quotients well below 1. However, refined models and further analysis for sensitive groups remain critical for a deeper analysis of risk.