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Generative adversarial networks for synthetic longitudinal electronic health records enabling cardiovascular digital twins
Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention.
Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention.ORCID iD: 0000-0003-3363-7414
Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention. Research Unit of Artificial Intelligence and Computer Systems, Università Campus Biomedico di Roma, Rome, Italy.ORCID iD: 0000-0003-2621-072X
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0003-4100-8298
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2025 (English)In: 2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS) / [ed] A. Rodriguez-Gonzalez; R. Sicilia; L. Prieto-Santamaria; G.A. Papadopoulos; V. Guarrasi; M.T. Cazzolato; B. Kane, Institute of Electrical and Electronics Engineers (IEEE), 2025, p. 25-28Conference paper, Published paper (Refereed)
Abstract [en]

The silent progression of cardiovascular disease (CVD) is a major problem particularly in CVD prevention. New techniques enabled by the rise of electronic health records may facilitate CVD prevention. Both public health research and big data applications, such as digital twins, are dependent on access to longitudinal and sensitive data; a challenge which may be facilitated by access to longitudinal synthetic data. In this study, we establish a fidelity benchmark for longitudinal synthetic data by extending a well-known method for cross-sectional synthetic data to a longitudinal application within CVD. We find that the univariate distributional difference between the real and the synthetic data is kept low and that pairwise relations are preserved in the synthetic data. Further, we see that the variable-wise temporal trends are preserved, yet may be more extensively studied and have some room for improvement. The results of this study is important to enable future studies within public health prevention and cardiovascular digital twins.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2025. p. 25-28
Series
IEEE International Symposium on Computer-Based Medical Systems, ISSN 2372-9198
Keywords [en]
Synthetic data, digital twins, cardiovascular disease prevention
National Category
Public Health, Global Health and Social Medicine
Identifiers
URN: urn:nbn:se:umu:diva-247134DOI: 10.1109/CBMS65348.2025.00015ISI: 001544273800005Scopus ID: 2-s2.0-105010649225ISBN: 9798331526115 (print)ISBN: 9798331526108 (electronic)OAI: oai:DiVA.org:umu-247134DiVA, id: diva2:2018292
Conference
38th International Symposium on Computer Based Medical Systems-CBMS-Annual, JUN 18-20, 2025, Madrid, SPAIN
Available from: 2025-12-02 Created: 2025-12-02 Last updated: 2025-12-02Bibliographically approved

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Bertgren, AmandaÖhberg, FredrikSoda, PaoloNäslund, UlfWennberg, PatrikGrönlund, Christer

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Bertgren, AmandaÖhberg, FredrikSoda, PaoloNäslund, UlfWennberg, PatrikGrönlund, Christer
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Department of Diagnostics and InterventionDepartment of Public Health and Clinical Medicine
Public Health, Global Health and Social Medicine

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