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Metabolic interactions between bacterial co-isolates from catheter-associated urinary tract infections
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).ORCID iD: 0000-0002-4931-2641
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).ORCID iD: 0000-0002-7912-7447
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Odesa I. I. Mechnikov National University, Odesa, Ukraine.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
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2026 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 16, no 1, article id 2061Article in journal (Refereed) Published
Abstract [en]

Catheter-associated urinary tract infections (CAUTI) are complex infections often involving multi-species bacteria. Escherichia coli is frequently an early coloniser. Subsequent colonisation by Pseudomonas aeruginosa and coexistence mechanisms between the two strains within urethral catheters is not yet fully understood. In this study, metabolic adaptations between co-isolated clinical E. coli and P. aeruginosa strains were investigated. It was found that P. aeruginosa outgrew E. coli in artificial urine medium (AUM), whereas E. coli dominated in culture broth such as Iso-sensitest. No evidence of direct antagonism was observed. Metabolite analyses revealed distinct metabolite patterns indicating cross-feeding and metabolic adaptations. In AUM, stress-response metabolites were elevated. Additionally, E. coli appeared to experience Fe-limitation in AUM, while the same was not observed for P. aeruginosa. The results highlight the influence of nutrient conditions on processes within mixed biofilms.
Place, publisher, year, edition, pages
Nature Publishing Group, 2026. Vol. 16, no 1, article id 2061
National Category
Microbiology in the Medical Area
Identifiers
URN: urn:nbn:se:umu:diva-249023DOI: 10.1038/s41598-025-33855-1PubMedID: 41535363Scopus ID: 2-s2.0-105027656484OAI: oai:DiVA.org:umu-249023DiVA, id: diva2:2032704
Funder
The Kempe Foundations, JCK 22–0071Swedish Research Council, 2018–03879Umeå University
Note

Correction: Sokol, D., Rzhepishevska, O., Marynova, I. et al. Correction: Metabolic interactions between bacterial co-isolates from catheter-associated urinary tract infections. Sci Rep 16, 6579 (2026). https://doi.org/10.1038/s41598-026-39740-9

Available from: 2026-01-27 Created: 2026-01-27 Last updated: 2026-02-18Bibliographically approved

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Sokol, DmytroRzhepishevska, Olena IMonsen, Tor J.Antti, HenrikRamstedt, Madeleine

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