Latin America is at the forefront of global progress in smoke free workplaces. Comprehensive smoke free laws have been implemented in four countries, and in many cities, states and provinces. More than 130 million people in Latin America are now protected from secondhand tobacco smoke. Nevertheless, a survey of tobacco control advocates and governments in Latin America found several challenges to progress in smoke free workplaces: the need for voluntary workplace programs where there is no smoke free legislation; weak legislation or lack of comprehensive national smoke free laws; tobacco industry attempts to undermine progress with smoke free laws or overturn existing laws via litigation; lack of compliance with laws; the need for monitoring and evaluation of smoke free laws; the need to make better use of mass media campaigns; and strengthening civil society. However, much progress has already been achieved to address these challenges, in particular through collaborations and the exchange of experience and expertise across Latin America.