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Cerebral metabolism during air transport of patients after surgery for malignant glioma
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
2008 (Engelska)Ingår i: Aviation, Space and Environmental Medicine, ISSN 0095-6562, E-ISSN 1943-4448, Vol. 79, nr 7, s. 700-703Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

INTRODUCTION: Post-operative air transport of patients following an intracranial procedure is not uncommon. The transport itself may pose a risk, and if there are harmful effects to the brain this should be reflected in the brain metabolism. The aim of this study was to analyze possible alterations in cerebral metabolism that could be caused by air transport.

METHODS: Four patients with glioblastomas were operated with a biopsy or a craniotomy. During this procedure microdialysis catheters were placed in tumor tissue or brain adjacent to tumor and in normal cerebral tissue. In this study we have analyzed cerebral glucose metabolites (glucose, lactate / pyruvate ratio), glycerol, and glutamate at five time points during a 24-h period including air transport.

RESULTS: Analyzing mean values, there was a small but significant increase in the lactate/pyruvate ratio from 45.18 to 47.78 in normal cerebral tissue after air transport compared to a previous fasting sample. For tumor tissue there was a small decrease in glucose from 1.04 to 0.92 mmol L(-1) and an increase in glutamate from 13.08 to 19.06 micromol L(-1). There were no other significant differences in the analyzed cerebral metabolites after air transport.

DISCUSSION: There were only minor differences in levels of cerebral metabolites after air transport compared to a previous fasting sample. Thus it seems that air transportation of the four reported patients did not cause any major cellular damage or metabolic changes as assessed by extracellular glucose, lactate/pyruvate ratio, glycerol, or glutamate.

Ort, förlag, år, upplaga, sidor
2008. Vol. 79, nr 7, s. 700-703
Nyckelord [en]
air transport, biopsy, cerebral metabolism, craniotomy, glioblastomas, microdialysis
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-25213DOI: 10.3357/ASEM.2280.2008PubMedID: 18619131OAI: oai:DiVA.org:umu-25213DiVA, id: diva2:229164
Tillgänglig från: 2009-08-11 Skapad: 2009-08-11 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Lindvall, PeterBergenheim, A Tommy

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