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Intrafusal myosin heavy chain expression of human masseter and biceps muscles at young age shows fundamental similarities but also marked differences
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Klinisk oral fysiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Anatomi.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Anatomi.
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Klinisk oral fysiologi.
2013 (Engelska)Ingår i: Histochemistry and Cell Biology, ISSN 0948-6143, E-ISSN 1432-119X, Vol. 139, nr 6, s. 895-907Artikel i tidskrift (Övrigt vetenskapligt) Published
Abstract [en]

Muscle spindles are skeletal muscle mechanoreceptors that provide proprioceptive information to the central nervous system. The human adult masseter muscle has greater number, larger and more complex muscle spindles than the adult biceps. For a better knowledge of muscle diversity and physiological properties, this study examined the myosin heavy chain (MyHC) expression of muscle spindle intrafusal fibres in the human young masseter and young biceps muscles by using a panel of monoclonal antibodies (mAbs) against different MyHC isoforms. Eight MyHC isoforms were detected in both muscles-slow-tonic, I, IIa, IIx, foetal, embryonic, α-cardiac and an isoform not previously reported in intrafusal fibres, termed IIx'. Individual fibres co-expressed 2-6 isoforms. MyHC-slow tonic separated bag(1), AS-bag(1) and bag(2) fibres from chain fibres. Typically, bag fibres also expressed MyHC-I and α-cardiac, whereas chain fibres expressed IIa and foetal. In the young masseter 98 % of bag(1) showed MyHC-α cardiac versus 30 % in the young biceps, 35 % of bag(2) showed MyHC-IIx' versus none in biceps, 17 % of the chain fibres showed MyHC-I versus 61 % in the biceps. In conclusion, the result showed fundamental similarities in intrafusal MyHC expression between young masseter and biceps, but also marked differences implying muscle-specific proprioceptive control, probably related to diverse evolutionary and developmental origins. Finding of similarities in MyHC expression between young and adult masseter and biceps muscle spindles, respectively, in accordance with previously reported similarities in mATPase fibre type composition suggest early maturation of muscle spindles, preceding extrafusal fibres in growth and maturation.

Ort, förlag, år, upplaga, sidor
Springer, 2013. Vol. 139, nr 6, s. 895-907
Nyckelord [en]
Jaw, Limb, Human, Muscle spindles, Intrafusal fibres, Myosin heavy chain, Immuno-histochemistry
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:umu:diva-46771DOI: 10.1007/s00418-012-1072-7ISI: 000319167800008PubMedID: 23306907Scopus ID: 2-s2.0-84878242137OAI: oai:DiVA.org:umu-46771DiVA, id: diva2:440654
Tillgänglig från: 2011-09-13 Skapad: 2011-09-13 Senast uppdaterad: 2023-03-23Bibliografiskt granskad
Ingår i avhandling
1. Extra- and intrafusal muscle fibre type compositions of the human masseter at young age.: In perspective of growth and functional maturation of the jaw-face motor system.
Öppna denna publikation i ny flik eller fönster >>Extra- and intrafusal muscle fibre type compositions of the human masseter at young age.: In perspective of growth and functional maturation of the jaw-face motor system.
2011 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Muscles control body posture and movement by extrafusal and intrafusal (muscle spindle) fibres. The purpose of this thesis was to provide insight into the muscular basis for human jaw function at young age. Extrafusal and intrafusal fibres in the young masseter, and for comparison young biceps, were examined for composition of fibre types and myosin heavy chain (MyHC) isoforms by means of morphological, enzyme-histochemical, biochemical and immuno-histochemical techniques. For evaluation of plasticity during life span the data for young muscles were compared with previous reported data for adult and elderly muscles.

The results showed significant differences in extrafusal fibre types and MyHC expression between young masseter and young biceps and between young masseter and masseter in adults and elderly. Compared with young biceps, young masseter was more intricate in composition of extrafusal MyHC expression. Muscle spindles were larger and more frequent in the masseter than in the biceps. Masseter and biceps muscle spindles showed fundamental similarities but also marked differences in MyHC expression.

The results suggest that the young masseter is specialized in fibre types already at young age and shows a unique fibre type growth pattern. Whereas masseter extrafusal fibres display marked plasticity in fibre types and MyHC isoforms during life span muscle spindles/intrafusal fibres are morphologically mature already at young age and precede extrafusal fibres in growth and maturation. Results showed similarities in intrafusal MyHC expression between young masseter and biceps, but also differences implying muscle specific proprioceptive control. Differences in fibre types and MyHC expression between young masseter and young biceps extrafusal fibres are proposed to reflect diverse evolutionary and developmental origins and accord with the masseter and biceps being separate allotypes of muscle.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå University, 2011. s. 76
Serie
Umeå University odontological dissertations, ISSN 0345-7532 ; 120
Nyckelord
jaw, limb, human, muscle, morphology, fibre type, myosin heavy chain, muscle spindle
Nationell ämneskategori
Odontologi
Forskningsämne
anatomi
Identifikatorer
urn:nbn:se:umu:diva-46667 (URN)978-91-7459-285-6 (ISBN)
Disputation
2011-09-30, Tandläkarhögskolan, byggnad 1D, 9 tr., sal B, Umeå universitet, Umeå, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2011-09-09 Skapad: 2011-09-09 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Österlund, CatharinaLiu, Jing-XiaThornell, Lars-EricEriksson, Per-Olof

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Österlund, CatharinaLiu, Jing-XiaThornell, Lars-EricEriksson, Per-Olof
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Klinisk oral fysiologiAnatomi
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Histochemistry and Cell Biology
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