Derivatives of 8-hydroxyquinoline-antibacterial agents that target intra- and extracellular Gram-negative pathogensVisa övriga samt affilieringar
2012 (Engelska)Ingår i: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1464-3405, Vol. 22, nr 10, s. 3550-3553Artikel i tidskrift (Refereegranskat) Published
Fritextbeskrivning
Abstract [en]
Small molecule screening identified 5-nitro-7-((4-phenylpiperazine-1-yl-)methyl)quinolin-8-ol INP1750 as a putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. In this study we report structure-activity relationships for inhibition of T3S and show that the most potent compounds target both the extracellular bacterium Y. pseudotuberculosis and the intracellular pathogen Chlamydia trachomatis in cell-based infection models.
Ort, förlag, år, upplaga, sidor
Elsevier, 2012. Vol. 22, nr 10, s. 3550-3553
Nationell ämneskategori
Biokemi Molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-54401DOI: 10.1016/j.bmcl.2012.03.096PubMedID: 22525317Scopus ID: 2-s2.0-84860482727OAI: oai:DiVA.org:umu-54401DiVA, id: diva2:523734
Anmärkning
Available online 6 April 2012
2012-04-262012-04-252025-02-20Bibliografiskt granskad