Creativity and talent are considered key-factors in regional development due to the connection between growth, city regions and human capital. To come to a deeper understanding on the relevance of recent amenity-driven theories and how they are related to employment and GRP at regional level, this paper analyses the influence of business-climate (business friendly assets) and people-climate (amenities). Based on panel-data regressions, we show that both business- and people-climate is related to regional performance. The exact nature of these relationships is however dependent on how both regional performance and business- or people climate is defined.