Four-Component Assembly of Natural-Product-Like Ring-Fused IsoquinuclidinesVisa övriga samt affilieringar
2013 (Engelska)Ingår i: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, Vol. 2013, nr 33, s. 7476-7479Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
A four-component reaction between formyl-substituted 2-pyridones, aldehydes, amines, and activated alkenes has been developed. The resulting products are ring-fused natural-product-like isoquinuclidines. Three carbon–carbon bonds, two carbon–nitrogen bonds, and four or five stereocentres are formed in the reaction with overall product yields in the range 23–67 %. In most cases a single diastereomer was obtained. An intramolecular version of the reaction yielded analogues of the multi-ring-fused natural product catharanthine in a single step.
Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2013. Vol. 2013, nr 33, s. 7476-7479
Nyckelord [en]
multicomponent reactions, natural products, fused-ring systems, nitrogen heterocycles
Nationell ämneskategori
Kemi
Identifikatorer
URN: urn:nbn:se:umu:diva-82338DOI: 10.1002/ejoc.201301371ISI: 000326968100006Scopus ID: 2-s2.0-84887627648OAI: oai:DiVA.org:umu-82338DiVA, id: diva2:660686
2013-10-302013-10-302023-03-24Bibliografiskt granskad