Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Estimating marginal causal effects in a secondary analysis of case-control data
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik. (Stat4Reg)ORCID-id: 0000-0002-1174-5126
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik. (Stat4Reg)
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
2017 (Engelska)Ingår i: Statistics in Medicine, ISSN 0277-6715, E-ISSN 1097-0258, Vol. 36, nr 15, s. 2404-2419Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

When an initial case-control study is performed, data can be used in a secondary analysis to evaluate the effect of the case-defining event on later outcomes. In this paper, we study the example in which the role of the event is changed from a response variable to a treatment of interest. If the aim is to estimate marginal effects, such as average effects in the population, the sampling scheme needs to be adjusted for. We study estimators of the average effect of the treatment in a secondary analysis of matched and unmatched case-control data where the probability of being a case is known. For a general class of estimators, we show the components of the bias resulting from ignoring the sampling scheme and demonstrate a design-weighted matching estimator of the average causal effect. In simulations, the finite sample properties of the design-weighted matching estimator are studied. Using a Swedish diabetes incidence register with a matched case-control design, we study the effect of childhood onset diabetes on the use of antidepressant medication as an adult.

Ort, förlag, år, upplaga, sidor
Hoboken: Wiley-Blackwell, 2017. Vol. 36, nr 15, s. 2404-2419
Nyckelord [en]
design-weighted estimation, matched case-control study, propensity score
Nationell ämneskategori
Sannolikhetsteori och statistik Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
statistik
Identifikatorer
URN: urn:nbn:se:umu:diva-94965DOI: 10.1002/sim.7277ISI: 000402799900007PubMedID: 28276084Scopus ID: 2-s2.0-85014944257OAI: oai:DiVA.org:umu-94965DiVA, id: diva2:756913
Forskningsfinansiär
Vetenskapsrådet, 07531Riksbankens Jubileumsfond, P11-0814:1Tillgänglig från: 2014-10-20 Skapad: 2014-10-20 Senast uppdaterad: 2023-03-24Bibliografiskt granskad
Ingår i avhandling
1. Causal inference and case-control studies with applications related to childhood diabetes
Öppna denna publikation i ny flik eller fönster >>Causal inference and case-control studies with applications related to childhood diabetes
2014 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Kausal inferens och fall-kontroll studier med applikationer inom barndiabetes
Abstract [en]

This thesis contributes to the research area of causal inference, where estimation of the effect of a treatment on an outcome of interest is the main objective. Some aspects of the estimation of average causal effects in observational studies in general, and case-control studies in particular, are explored.

An important part of estimating causal effects in an observational study is to control for covariates. The first paper of this thesis concerns the selection of minimal covariate sets sufficient for unconfoundedness of the treatment assignment. A data-driven implementation of two covariate selection algorithms is proposed and evaluated.

A common sampling scheme in epidemiology, and when investigating rare events, is the case-control design. In the second paper we study estimators of the marginal causal odds ratio in matched and independent case-control designs. Estimators that, under a logistic regression model, utilize information about the known prevalence of being a case is examined and compared through simulations.

The third paper investigates the particular situation where case-control sampled data is reused to estimate the effect of the case-defining event on an outcome of interest. The consequence of ignoring the design when estimating the average causal effect is discussed and a design-weighted matching estimator is proposed. The performance of the estimator is evaluated with simulation experiments, when matching on the covariates directly and when matching on the propensity score.

The last paper studies the effect of type 1 diabetes mellitus (T1DM) on school achievements using data from the Swedish Childhood Diabetes Register, a population-based incidence register. We apply theoretical results from the second and third papers in the estimation of the average causal effect within the T1DM population. A matching estimator that accounts for the matched case-control design is used.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet, 2014. s. 22
Serie
Statistical studies, ISSN 1100-8989 ; 48
Nyckelord
covariate selection, design-weighted estimation, marginal effect, matching, register study, treatment effect, type 1 diabetes mellitus
Nationell ämneskategori
Sannolikhetsteori och statistik
Forskningsämne
statistik
Identifikatorer
urn:nbn:se:umu:diva-94993 (URN)978-91-7601-151-5 (ISBN)
Disputation
2014-11-21, Hörsal F, Humanisthuset, Umeå universitet, Umeå, 10:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2014-10-24 Skapad: 2014-10-20 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Persson, EmmaWaernbaum, IngeborgLind, Torbjörn

Sök vidare i DiVA

Av författaren/redaktören
Persson, EmmaWaernbaum, IngeborgLind, Torbjörn
Av organisationen
StatistikPediatrik
I samma tidskrift
Statistics in Medicine
Sannolikhetsteori och statistikFolkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 836 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf