Elongator, a conserved complex required for wobble uridine modifications in EukaryotesShow others and affiliations
2014 (English)In: RNA Biology, ISSN 1547-6286, E-ISSN 1555-8584, Vol. 11, no 12, p. 1519-1528Article in journal (Refereed) Published
Abstract [en]
Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The role of this complex has been controversial as the pleiotropic phenotypes of Elongator mutants have implicated the complex in several cellular processes. However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm(5)) and 5-carbamoylmethyl (ncm(5)) side chains on uridines at wobble position in tRNA. In this review we summarize the cellular processes that have been linked to the Elongator complex and discuss its role in tRNA modification and regulation of translation. We also describe additional gene products essential for formation of ncm(5) and mcm(5) side chains at U-34 and their influence on Elongator activity.
Place, publisher, year, edition, pages
Taylor & Francis, 2014. Vol. 11, no 12, p. 1519-1528
Keywords [en]
elongator complex, KTI genes, SIT4, SAP genes, tRNA wobble uridine modifications, translation, uveromyces lactis gamma-toxin
National Category
Biochemistry Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-101625DOI: 10.4161/15476286.2014.992276ISI: 000350568300005PubMedID: 25607684Scopus ID: 2-s2.0-84924977986OAI: oai:DiVA.org:umu-101625DiVA, id: diva2:801497
2015-04-092015-04-072025-02-20Bibliographically approved