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Aims: To investigate regional differences and time trends in women’s overweight and obesity in Sweden. Methods: Using datafrom the Swedish Medical Birth Register (women aged ⩾18 years, first pregnancy only) and the Total Population Registeraccessed through the Umeå SIMSAM Lab, age-standardized prevalence of pre-pregnancy overweight/obesity (BMI ⩾ 25 kg/m2) and obesity (BMI ⩾ 30 kg/m2) were estimated by county for the years 1992, 2000, and 2010. Maps were created usingArcMap v10.2.2 to display regional variations over time and logistic regression analyses were used to assess if the observedtrends were significant. Results: The prevalence of pre-pregnancy overweight/obesity and obesity increased significantly inall Swedish counties between 1992, and 2010. In 2010, Södermanland and Gotland exhibited the highest age-standardizedoverweight/obesity (39.7%) and obesity (15.1%) prevalence, respectively. The sharpest increases between 1992 and 2010were observed in Västerbotten for overweight/obesity (75% increase) and in Gotland for obesity (233% increase). Across theyears, Stockholm had the lowest prevalence of overweight/obesity (26.3% in 2010) and obesity (7.3% in 2010) and one ofthe least steep increases in prevalence of both between 1992 and 2010. Conclusions: Substantial regional differencesin pre-pregnancy overweight and obesity prevalence are apparent in Sweden. Further research should elucidatethe mechanisms causing these differences.