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One-leg hop kinematics 20years following anterior cruciate ligament rupture: Data revisited using functional data analysis
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
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2015 (English)In: Clinical Biomechanics, ISSN 0268-0033, E-ISSN 1879-1271, Vol. 30, no 10, p. 1153-1161Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Despite interventions, anterior cruciate ligament ruptures can cause long-term deficits. To assist in identifying and treating deficiencies, 3D-motion analysis is used for objectivizing data. Conventional statistics are commonly employed to analyze kinematics, reducing continuous data series to discrete variables. Conversely, functional data analysis considers the entire data series.

METHODS: Here, we employ functional data analysis to examine and compare the entire time-domain of knee-kinematic curves from one-leg hops between and within three groups. All subjects (n=95) were part of a long-term follow-up study involving anterior cruciate ligament ruptures treated ~20years ago conservatively with physiotherapy only or with reconstructive surgery and physiotherapy, and matched knee-healthy controls.

FINDINGS: Between-group differences (injured leg, treated groups; non-dominant leg, controls) were identified during the take-off and landing phases, and in the sagittal (flexion/extension) rather than coronal (abduction/adduction) and transverse (internal/external) planes. Overall, surgical and control groups demonstrated comparable knee-kinematic curves. However, compared to controls, the physiotherapy-only group exhibited less flexion during the take-off (0-55% of the normalized phase) and landing (44-73%) phase. Between-leg differences were absent in controls and the surgically treated group, but observed during the flight (4-22%, injured leg>flexion) and the landing (57-85%, injured leg<internal rotation) phases in the physiotherapy-only group.

INTERPRETATION: Functional data analysis identified specific functional knee-joint deviations from controls persisting 20years post anterior cruciate ligament rupture, especially when treated conservatively. This approach is suggested as a means for comprehensively analyzing complex movements, adding to previous analyses.

Place, publisher, year, edition, pages
2015. Vol. 30, no 10, p. 1153-1161
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:umu:diva-111923DOI: 10.1016/j.clinbiomech.2015.08.010ISI: 000366790400022PubMedID: 26365484Scopus ID: 2-s2.0-84959229856OAI: oai:DiVA.org:umu-111923DiVA, id: diva2:874183
Available from: 2015-11-26 Created: 2015-11-26 Last updated: 2025-02-11Bibliographically approved
In thesis
1. Non-parametric methods for functional data
Open this publication in new window or tab >>Non-parametric methods for functional data
2020 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Icke-parametriska metoder för funktionella data
Abstract [en]

In this thesis we develop and study non-parametric methods within three major areas of functional data analysis: testing, clustering and prediction. The thesis consists of an introduction to the field, a presentation and discussion of the three areas, and six papers.

In Paper I, we develop a procedure for testing for group differences in functional data. In case of significant group differences, the test procedure identifies which of the groups that significantly differ, and also the parts of the domain they do so, while controlling the type I error of falsely rejecting the null hypothesis. In Paper II, the methodology introduced in Paper I is applied to knee kinematic curves from a one-leg hop for distance to test for differences within and between three groups of individuals (with and without knee deficits). It was found that two of the groups differed in their knee kinematics. We also found that the individual kinematic patterns differed between the two legs in one of the groups. In Paper III, we test for group differences in three groups with respect to joint kinematics from a vertical one-leg hop using a novel method that allows accounting for multiple joints at the same time. The aim of Paper III, as one of few within the field of biomechanics, is to illustrate how different choices prior to the analysis can result in different contrasting conclusions. Specifically, we show how the conclusions depend on the choice of type of movement curve, the choice of leg for between-group comparisons and the included joints.

In Paper IV, we present a new non-parametric clustering method for dependent functional data, the double clustering bagging Voronoi method. The objective of the method is to identify latent group structures that slowly vary over domain and give rise to different frequency patterns of functional data object types. The method uses a bagging strategy based on random Voronoi tessellations in which local representatives are formed and clustered. Combined with the clustering method, we also propose a multiresolution approach which allows identification of latent structures at different scales. A simulated dataset is used to illustrate the method's potential in finding stable clusters at different scales. The method is also applied to varved lake sediment data with the aim of reconstructing the climate over the past 6000 years, at different resolutions. In Paper V, we expand and modify the bagging strategy used in Paper IV, by considering different methods of generating the tessellations and clustering the local representatives of the tessellations. We propose new methods for clustering dependent categorical data (e.g., labelled functional data) along a one-dimensional domain, which we also compare in a simulation study. 

In Paper VI, two kriging approaches to predict spatial functional processes are compared, namely functional kriging and spatio-temporal kriging. A simulation study is conducted to compare their prediction performance and computational times. The overall results show that prediction performance is about the same for stationary spatio-temporal processes while functional kriging works better for non-stationary spatio-temporal processes. Furthermore, the computational time for (ordinary) kriging for functional data, was considerably lower than spatio-temporal kriging. Conditions are also formulated under which it is proved that the two functional kriging methods: ordinary kriging for functional data and pointwise functional kriging coincide.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2020. p. 32
Series
Research report in mathematical statistics, ISSN 1653-0829 ; 72/20
Keywords
functional data analysis, testing, clustering, prediction, inference, bagging Voronoi strategy, kriging, dependency
National Category
Probability Theory and Statistics
Research subject
Mathematical Statistics
Identifiers
urn:nbn:se:umu:diva-175594 (URN)978-91-7855-374-7 (ISBN)978-91-7855-375-4 (ISBN)
Public defence
2020-10-30, Aula Biologica, Biologihuset, Umeå, 10:15 (English)
Opponent
Supervisors
Available from: 2020-10-09 Created: 2020-10-05 Last updated: 2020-10-06Bibliographically approved

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Strandberg, JohanAbramowicz, KonradSchelin, LinaHäger, Charlotte

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