Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.ORCID-id: 0000-0003-2523-1940
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Visa övriga samt affilieringar
2015 (Engelska)Ingår i: Parkinson's Disease, ISSN 2090-8083, E-ISSN 2042-0080, Vol. 1, artikel-id 15024Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The assembly process of a-synuclein toward amyloid fibers is linked to neurodegeneration in Parkinson´s disease. In the present study, we capitalized on the in vitro discovery of a small-molecule accelerator of a-synuclein amyloid formation and assessed its effects when injected in brains of normal mice. An accelerator and an inhibitor of a-synuclein amyloid formation, as well as vehicle only, were injected into the striatum of normal mice and follwed by behavioral evaluation, immunohistochemistry, and metabolomics up to six months later. The effects of molecules injected into the substansia nigra of normal and a-synuclein knockout mice were also analyzed. When accelerator or inhibitor was injected into the brain of normal mice no acute compound toxicity was found. However, 6 months after single striatal injection of accelerator, mice sensorimotor functions were impaired, whereas mice injected with inhibitor had no dysfunctions. Injection of accelerator (but not inhibitor or vehicle) into the substantia nigra revealed singificant loss of tyrosine hydroxylase (TH)-positive neurons after 3 months. No loss of TH-positive neurons was found in a-synuclein knock-out mice injected with accelerator intor the substantia nigra. Metabolic serum profiles from accelerator-injected normal mice matched those of newly diagnosed Parkinson´s disease patients, whereas the profiles from inhibitor-injected normal mice matched controls. Single inoculation of a small-molecule amyloid accelerator may be a new approach for studies of early events during dopamine neurodegeneration in mice.

Ort, förlag, år, upplaga, sidor
2015. Vol. 1, artikel-id 15024
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) Neurovetenskaper
Forskningsämne
cellforskning
Identifikatorer
URN: urn:nbn:se:umu:diva-117116DOI: 10.1038/npjparkd.2015.24Scopus ID: 2-s2.0-84978034239OAI: oai:DiVA.org:umu-117116DiVA, id: diva2:905282
Tillgänglig från: 2016-02-22 Skapad: 2016-02-22 Senast uppdaterad: 2024-07-02Bibliografiskt granskad

Open Access i DiVA

fulltext(1704 kB)457 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1704 kBChecksumma SHA-512
e00932d8fabace6de3fe1f3e32e541b4ff250ed0b101b7ab52125bdeb741c7f265da106c29ec8707c96da0f550751fc5f1c5bff62989566b74f3a55364ace470
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextScopus

Person

Chermenina, MariaChorell, ErikAntti, HenrikAlmqvist, FredrikStrömberg, IngridWittung-Stafshede, Pernilla

Sök vidare i DiVA

Av författaren/redaktören
Chermenina, MariaChorell, ErikAntti, HenrikAlmqvist, FredrikStrömberg, IngridWittung-Stafshede, Pernilla
Av organisationen
Institutionen för integrativ medicinsk biologi (IMB)Kemiska institutionen
I samma tidskrift
Parkinson's Disease
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 457 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 1584 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf