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Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Fysiologisk kemi.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
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2016 (Engelska)Ingår i: American Journal of Physiology. Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, E-ISSN 1522-1490, Vol. 310, nr 11, s. R1045-R1052Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Genetic factors confer risk for cardiovascular disease. Recently, large genome-wide population studies have shown associations between genomic loci close to LRIG3 and heart failure and plasma high-density lipoprotein (HDL) cholesterol level. Here, we ablated Lrig3 in mice and investigated the importance of Lrig3 for heart function and plasma lipid levels. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze Lrig3 expression in the hearts of wild-type and Lrig3-deficient mice. In addition, molecular, physiological, and functional parameters such as organ weights, heart rate, blood pressure, heart structure and function, gene expression in the heart, and plasma insulin, glucose, and lipid levels were evaluated. The Lrig3-deficient mice were smaller than the wild-type mice but otherwise appeared grossly normal. Lrig3 was expressed at detectable but relatively low levels in adult mouse hearts. At 9 mo of age, ad libitum-fed Lrig3-deficient mice had lower insulin levels than wildtype mice. At 12 mo of age, Lrig3-deficient mice exhibited increased blood pressure, and the Lrig3-deficient female mice displayed signs of cardiac hypertrophy as assessed by echocardiography, heart-to-body weight ratio, and expression of the cardiac hypertrophy marker gene Nppa. Additionally, Lrig3-deficient mice had reduced plasma HDL cholesterol and free glycerol. These findings in mice complement the human epidemiological results and suggest that Lrig3 may influence heart function and plasma lipid levels in mice and humans.

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2016. Vol. 310, nr 11, s. R1045-R1052
Nationell ämneskategori
Fysiologi
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URN: urn:nbn:se:umu:diva-122617DOI: 10.1152/ajpregu.00309.2015ISI: 000377021700004PubMedID: 27009049Scopus ID: 2-s2.0-84984799272OAI: oai:DiVA.org:umu-122617DiVA, id: diva2:939829
Tillgänglig från: 2016-06-20 Skapad: 2016-06-20 Senast uppdaterad: 2023-03-23Bibliografiskt granskad

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Hellström, MartinEricsson, MadeleneJohansson, BengtFaraz, MahmoodAnderson, FredrickHenriksson, RogerNilsson, Stefan K.Hedman, Håkan

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Hellström, MartinEricsson, MadeleneJohansson, BengtFaraz, MahmoodAnderson, FredrickHenriksson, RogerNilsson, Stefan K.Hedman, Håkan
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American Journal of Physiology. Regulatory Integrative and Comparative Physiology
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