Umeå University's logo

umu.sePublications
Change search
Refine search result
1 - 13 of 13
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    de Pierrefeu, Amicie
    et al.
    NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France.
    Fovet, Thomas
    Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F- 59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France.
    Hadj-Selem, Fouad
    Energy Transition Institute: VeDeCoM, France.
    Löfstedt, Tommy
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
    Ciuciu, Philippe
    NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France; INRIA, CEA, Parietal team, Univ. Paris-Saclay, France.
    Lefebvre, Stephanie
    Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F-59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France.
    Thomas, Pierre
    Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F-59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France.
    Lopes, Renaud
    Imaging Dpt., Neuroradiology unit, CHU Lille, Lille F-59000, France; U1171 - Degenerative and Vascular Cognitive Disorders, Univ. Lille, INSERM, CHU Lille, Lille F-59000, France.
    Jardri, Renaud
    Univ. Lille, CNRS UMR 9193, Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab), PsyCHIC team, Lille F-59000, France; CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France.
    Duchesnay, Edouard
    NeuroSpin, CEA, Paris-Saclay, Gif-sur-Yvette, France.
    Prediction of activation patterns preceding hallucinations in patients with schizophrenia using machine learning with structured sparsity2018In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 39, no 4, p. 1777-1788Article in journal (Refereed)
    Abstract [en]

    Despite significant progress in the field, the detection of fMRI signal changes during hallucinatory events remains difficult and time-consuming. This article first proposes a machine-learning algorithm to automatically identify resting-state fMRI periods that precede hallucinations versus periods that do not. When applied to whole-brain fMRI data, state-of-the-art classification methods, such as support vector machines (SVM), yield dense solutions that are difficult to interpret. We proposed to extend the existing sparse classification methods by taking the spatial structure of brain images into account with structured sparsity using the total variation penalty. Based on this approach, we obtained reliable classifying performances associated with interpretable predictive patterns, composed of two clearly identifiable clusters in speech-related brain regions. The variation in transition-to-hallucination functional patterns not only from one patient to another but also from one occurrence to the next (e.g., also depending on the sensory modalities involved) appeared to be the major difficulty when developing effective classifiers. Consequently, second, this article aimed to characterize the variability within the prehallucination patterns using an extension of principal component analysis with spatial constraints. The principal components (PCs) and the associated basis patterns shed light on the intrinsic structures of the variability present in the dataset. Such results are promising in the scope of innovative fMRI-guided therapy for drug-resistant hallucinations, such as fMRI-based neurofeedback.

  • 2. de Zwarte, Sonja M. C.
    et al.
    Brouwer, Rachel M.
    Agartz, Ingrid
    Alda, Martin
    Alonso-Lana, Silvia
    Bearden, Carrie E.
    Bertolino, Alessandro
    Bonvino, Aurora
    Bramon, Elvira
    Buimer, Elizabeth E. L.
    Cahn, Wiepke
    Canales-Rodríguez, Erick J.
    Cannon, Dara M.
    Cannon, Tyrone D.
    Caseras, Xavier
    Castro-Fornieles, Josefina
    Chen, Qiang
    Chung, Yoonho
    De la Serna, Elena
    Del Mar Bonnin, Caterina
    Demro, Caroline
    Di Giorgio, Annabella
    Doucet, Gaelle E.
    Eker, Mehmet Cagdas
    Erk, Susanne
    Fatjó-Vilas, Mar
    Fears, Scott C.
    Foley, Sonya F.
    Frangou, Sophia
    Fullerton, Janice M.
    Glahn, David C.
    Goghari, Vina M.
    Goikolea, Jose M.
    Goldman, Aaron L.
    Gonul, Ali Saffet
    Gruber, Oliver
    Hajek, Tomas
    Hawkins, Emma L.
    Heinz, Andreas
    Hidiroglu Ongun, Ceren
    Hillegers, Manon H.J.
    Houenou, Josselin
    Hulshoff Pol, Hilleke E.
    Hultman, Christina M.
    Ingvar, Martin
    Johansson, Viktoria
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Jönsson, Erik G.
    Kane, Fergus
    Kempton, Matthew J.
    Koenis, Marinka M. G.
    Kopecek, Miloslav
    Krämer, Bernd
    Lawrie, Stephen M.
    Lenroot, Rhoshel K.
    Marcelis, Machteld
    Mattay, Venkata S.
    McDonald, Colm
    Meyer-Lindenberg, Andreas
    Michielse, Stijn
    Mitchell, Philip B.
    Moreno, Dolores
    Murray, Robin M.
    Mwangi, Benson
    Nabulsi, Leila
    Newport, Jason
    Olman, Cheryl A.
    van Os, Jim
    Overs, Bronwyn J.
    Ozerdem, Aysegul
    Pergola, Giulio
    Picchioni, Marco M.
    Piguet, Camille
    Pomarol-Clotet, Edith
    Radua, Joaquim
    Ramsay, Ian S.
    Richter, Anja
    Roberts, Gloria
    Salvador, Raymond
    Saricicek Aydogan, Aybala
    Sarró, Salvador
    Schofield, Peter R.
    Simsek, Esma M.
    Simsek, Fatma
    Soares, Jair C.
    Sponheim, Scott R.
    Sugranyes, Gisela
    Toulopoulou, Timothea
    Tronchin, Giulia
    Vieta, Eduard
    Walter, Henrik
    Weinberger, Daniel R.
    Whalley, Heather C.
    Wu, Mon-Ju
    Yalin, Nefize
    Andreassen, Ole A.
    Ching, Christopher R. K.
    Thomopoulos, Sophia I.
    van Erp, Theo G. M.
    Jahanshad, Neda
    Thompson, Paul M.
    Kahn, René S.
    van Haren, Neeltje E. M.
    Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder2022In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 43, no 1, p. 414-430Article in journal (Refereed)
    Abstract [en]

    First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

    Download full text (pdf)
    fulltext
  • 3.
    Demnitz, Naiara
    et al.
    Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
    Gates, Anne T.
    Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Mortensen, Erik L.
    Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Garde, Ellen
    Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Wimmelmann, Cathrine L.
    Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Siebner, Hartwig R.
    Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health sciences, Copenhagen University, Copenhagen, Denmark.
    Kjaer, Michael
    Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Boraxbekk, Carl-Johan
    Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Neurology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health sciences, Copenhagen University, Copenhagen, Denmark.
    Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults2023In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 44, no 11, p. 4299-4309Article in journal (Refereed)
    Abstract [en]

    Understanding individual variability in response to physical activity is key to developing more effective and personalised interventions for healthy ageing. Here, we aimed to unpack individual differences by using longitudinal data from a randomised-controlled trial of a 12-month muscle strengthening intervention in older adults. Physical function of the lower extremities was collected from 247 participants (66.3 ± 2.5 years) at four time-points. At baseline and at year 4, participants underwent 3 T MRI brain scans. K-means longitudinal clustering was used to identify patterns of change in chair stand performance over 4 years, and voxel-based morphometry was applied to map structural grey matter volume at baseline and year 4. Results identified three groups showing trajectories of poor (33.6%), mid (40.1%), and high (26.3%) performance. Baseline physical function, sex, and depressive symptoms significantly differed between trajectory groups. High performers showed greater grey matter volume in the motor cerebellum compared to the poor performers. After accounting for baseline chair stand performance, participants were re-assigned to one of four trajectory-based groups: moderate improvers (38.9%), maintainers (38.5%), improvers (13%), and decliners (9.7%). Clusters of significant grey matter differences were observed between improvers and decliners in the right supplementary motor area. Trajectory-based group assignments were unrelated to the intervention arms of the study. In conclusion, patterns of change in chair stand performance were associated with greater grey matter volumes in cerebellar and cortical motor regions. Our findings emphasise that how you start matters, as baseline chair stand performance was associated with cerebellar volume 4 years later.

    Download full text (pdf)
    fulltext
  • 4.
    Dima, Danai
    et al.
    Department of Psychology, School of Arts and Social Sciences, City University of London, London, United Kingdom; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Modabbernia, Amirhossein
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York, United States.
    Papachristou, Efstathios
    Psychology and Human Development, Institute of Education, University College London, London, United Kingdom.
    Doucet, Gaelle E.
    Boys Town National Research Hospital, NE, Omaha, United States.
    Agartz, Ingrid
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Aghajani, Moji
    Department of Psychiatry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands; Institute of Education & Child Studies, Section Forensic Family & Youth Care, Leiden University, Netherlands.
    Akudjedu, Theophilus N.
    Institute of Medical Imaging and Visualisation, Department of Medical Science and Public Health, Faculty of Health and Social Sciences, Bournemouth University, Poole, United Kingdom; Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
    Albajes-Eizagirre, Anton
    FIDMAG Germanes Hospitalàries, Madrid, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Alnæs, Dag
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Alpert, Kathryn I.
    Radiologics, Inc, IL, Chicago, United States.
    Andersson, Micael
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Andreasen, Nancy C.
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, IA, Iowa City, United States.
    Andreassen, Ole A.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Asherson, Philip
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Banaschewski, Tobias
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
    Bargallo, Nuria
    Imaging Diagnostic Centre, Hospital Clinic, Barcelona University Clinic, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Barcelona, Spain.
    Baumeister, Sarah
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
    Baur-Streubel, Ramona
    Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Wurzburg, Germany.
    Bertolino, Alessandro
    Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
    Bonvino, Aurora
    Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
    Boomsma, Dorret I.
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Borgwardt, Stefan
    Department of Psychiatry & Psychotherapy, University of Lübeck, Lubeck, Germany.
    Bourque, Josiane
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States.
    Brandeis, Daniel
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
    Breier, Alan
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    Brodaty, Henry
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
    Brouwer, Rachel M.
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
    Buitelaar, Jan K.
    Donders Center of Medical Neurosciences, Radboud University, Nijmegen, Netherlands; Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
    Busatto, Geraldo F.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Buckner, Randy L.
    Department of Psychology, Center for Brain Science, Harvard University, MA, Cambridge, United States; Department of Psychiatry, Massachusetts General Hospital, MA, Boston, United States.
    Calhoun, Vincent
    Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, USA Neurology, Radiology, Psychiatry and Biomedical Engineering, Emory University, GA, Atlanta, United States.
    Canales-Rodríguez, Erick J.
    FIDMAG Germanes Hospitalàries, Madrid, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Cannon, Dara M.
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
    Caseras, Xavier
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.
    Castellanos, Francisco X.
    Department of Child and Adolescent Psychiatry, New York University, NY, New York, United States.
    Cervenka, Simon
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
    Chaim-Avancini, Tiffany M.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Ching, Christopher R. K.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States.
    Chubar, Victoria
    Department of Neuroscience, KU Leuven, Mind-Body Research Group, Leuven, Belgium.
    Clark, Vincent P.
    Department of Psychology, University of New Mexico, NM, Albuquerque, United States; Mind Research Network, NM, Albuquerque, United States.
    Conrod, Patricia
    Department of Psychiatry, Université de Montréal, Montreal, Canada.
    Conzelmann, Annette
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tubingen, Germany.
    Crespo-Facorro, Benedicto
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; HU Virgen del Rocio, IBiS, University of Sevilla, Sevilla, Spain.
    Crivello, Fabrice
    Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Talence, France.
    Crone, Eveline A.
    Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Rotterdam, Netherlands; Faculteit der Sociale Wetenschappen, Instituut Psychologie, Universiteit Leiden, Leiden, Netherlands.
    Dale, Anders M.
    Center for Multimodal Imaging and Genetics, Department of Neuroscience and Department of Radiology, University of California-San Diego, CA, La Jolla, United States.
    Davey, Cristopher
    Department of Psychiatry, University of Melbourne, Melbourne, Australia.
    de Geus, Eco J. C.
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    de Haan, Lieuwe
    Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
    de Zubicaray, Greig I.
    Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
    den Braber, Anouk
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Dickie, Erin W.
    Kimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Research Institute, CAMH, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.
    Di Giorgio, Annabella
    Biological Psychiatry Lab, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
    Doan, Nhat Trung
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Dørum, Erlend S.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
    Ehrlich, Stefan
    Division of Psychological and Social Medicine and Developmental Neurosciences, Technische Universität Dresden, Dresden, Germany; Faculty of Medicine, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany.
    Erk, Susanne
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Espeseth, Thomas
    Department of Psychology, University of Oslo, Oslo, Norway; Bjørknes College, Oslo, Norway.
    Fatouros-Bergman, Helena
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
    Fisher, Simon E.
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.
    Fouche, Jean-Paul
    Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa.
    Franke, Barbara
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands.
    Frodl, Thomas
    Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.
    Fuentes-Claramonte, Paola
    FIDMAG Germanes Hospitalàries, Madrid, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Glahn, David C.
    Department of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital, Harvard Medical School, MA, Boston, United States.
    Gotlib, Ian H.
    Department of Psychology, Stanford University, CA, Stanford, United States.
    Grabe, Hans-Jörgen
    Department of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
    Grimm, Oliver
    Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany.
    Groenewold, Nynke A.
    Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa; Neuroscience Institute, University of Cape Town, Rondebosch, South Africa.
    Grotegerd, Dominik
    Department of Psychiatry and Psychotherapy, University of Münster, Munster, Germany.
    Gruber, Oliver
    Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
    Gruner, Patricia
    Department of Psychiatry, Yale University, CT, New Haven, United States; Learning Based Recovery Center, VA Connecticut Health System, CT, New Haven, United States.
    Gur, Rachel E.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States; Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States; Children's Hospital of Philadelphia, University of Pennsylvania, PA, Philadelphia, United States.
    Gur, Ruben C.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States; Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States; Children's Hospital of Philadelphia, University of Pennsylvania, PA, Philadelphia, United States.
    Harrison, Ben J.
    Melbourne Neuropsychiatry Center, University of Melbourne, Melbourne, Australia.
    Hartman, Catharine A.
    Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
    Hatton, Sean N.
    Brain and Mind Centre, University of Sydney, Sydney, Australia.
    Heinz, Andreas
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Heslenfeld, Dirk J.
    Departments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
    Hibar, Derrek P.
    Personalized Healthcare, Genentech, Inc, CA, South San Francisco, United States.
    Hickie, Ian B.
    Brain and Mind Centre, University of Sydney, Sydney, Australia.
    Ho, Beng-Choon
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, IA, Iowa City, United States.
    Hoekstra, Pieter J.
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
    Hohmann, Sarah
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
    Holmes, Avram J.
    Department of Psychology, Yale University, CT, New Haven, United States.
    Hoogman, Martine
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
    Hosten, Norbert
    Norbert Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, University of Greifswald, Greifswald, Germany.
    Howells, Fleur M.
    Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa; Neuroscience Institute, University of Cape Town, Rondebosch, South Africa.
    Hulshoff Pol, Hilleke E.
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
    Huyser, Chaim
    Bascule, Academic Centre for Children and Adolescent Psychiatry, Duivendrecht, Netherlands.
    Jahanshad, Neda
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States.
    James, Anthony
    Department of Psychiatry, Oxford University, Oxford, United Kingdom.
    Jernigan, Terry L.
    Center for Human Development, Departments of Cognitive Science, Psychiatry, and Radiology, University of California, CA, San Diego, United States.
    Jiang, Jiyang
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
    Jönsson, Erik G.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
    Joska, John A.
    Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa.
    Kahn, Rene
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York, United States.
    Kalnin, Andrew
    Department of Radiology, Ohio State University College of Medicine, OH, Columbus, United States.
    Kanai, Ryota
    Department of Neuroinformatics, Araya, Inc, Tokyo, Japan.
    Klein, Marieke
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands; Department of Psychiatry, University of California San Diego, CA, La Jolla, United States.
    Klyushnik, Tatyana P.
    Mental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russian Federation.
    Koenders, Laura
    Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
    Koops, Sanne
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
    Krämer, Bernd
    Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
    Kuntsi, Jonna
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Lagopoulos, Jim
    Sunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Sunshine Coast, Australia.
    Lázaro, Luisa
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
    Lebedeva, Irina
    Mental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russian Federation.
    Lee, Won Hee
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York, United States.
    Lesch, Klaus-Peter
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius-Maximilians Universität Würzburg, Wurzburg, Germany.
    Lochner, Christine
    SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
    Machielsen, Marise W. J.
    Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
    Maingault, Sophie
    Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Talence, France.
    Martin, Nicholas G.
    Queensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia.
    Martínez-Zalacaín, Ignacio
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.
    Mataix-Cols, David
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
    Mazoyer, Bernard
    Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Talence, France.
    McDonald, Colm
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
    McDonald, Brenna C.
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    McIntosh, Andrew M.
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
    McMahon, Katie L.
    School of Clinical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
    McPhilemy, Genevieve
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
    Menchón, José M.
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.
    Medland, Sarah E.
    Queensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia.
    Meyer-Lindenberg, Andreas
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
    Naaijen, Jilly
    Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
    Najt, Pablo
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
    Nakao, Tomohiro
    Department of Clinical Medicine, Kyushu University, Kyushu, Japan.
    Nordvik, Jan E.
    CatoSenteret Rehabilitation Hospital, Son, Norway.
    Nyberg, Lars
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
    Oosterlaan, Jaap
    Department of Clinical Neuropsychology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
    de la Foz, Víctor Ortiz-García
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, University Hospital “Marques de Valdecilla”, Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain; Instituto de Salud Carlos III, Madrid, Spain.
    Paloyelis, Yannis
    Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Pauli, Paul
    Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Wurzburg, Germany; Centre of Mental Health, University of Würzburg, Wurzburg, Germany.
    Pergola, Giulio
    Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
    Pomarol-Clotet, Edith
    FIDMAG Germanes Hospitalàries, Madrid, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Portella, Maria J.
    FIDMAG Germanes Hospitalàries, Madrid, Spain; Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Potkin, Steven G.
    Department of Psychiatry, University of California at Irvine, CA, Irvine, United States.
    Radua, Joaquim
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Barcelona, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
    Reif, Andreas
    Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany.
    Rinker, Daniel A.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Roffman, Joshua L.
    Department of Psychiatry, Massachusetts General Hospital, MA, Boston, United States.
    Rosa, Pedro G. P.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Sacchet, Matthew D.
    Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, MA, Boston, United States.
    Sachdev, Perminder S.
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
    Salvador, Raymond
    FIDMAG Germanes Hospitalàries, Madrid, Spain.
    Sánchez-Juan, Pascual
    Department of Psychiatry, University Hospital “Marques de Valdecilla”, Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
    Sarró, Salvador
    FIDMAG Germanes Hospitalàries, Madrid, Spain.
    Satterthwaite, Theodore D.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States.
    Saykin, Andrew J.
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    Serpa, Mauricio H.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Schmaal, Lianne
    Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
    Schnell, Knut
    Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
    Schumann, Gunter
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
    Sim, Kang
    Institute of Mental Health, Singapore, Singapore.
    Smoller, Jordan W.
    Center for Genomic Medicine, Massachusetts General Hospital, MA, Boston, United States.
    Sommer, Iris
    Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Göttingen, Netherlands.
    Soriano-Mas, Carles
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.
    Stein, Dan J.
    SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
    Strike, Lachlan T.
    Queensland Brain Institute, University of Queensland, Brisbane, Australia.
    Swagerman, Suzanne C.
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Tamnes, Christian K.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
    Temmingh, Henk S.
    Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa.
    Thomopoulos, Sophia I.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States.
    Tomyshev, Alexander S.
    Mental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russian Federation.
    Tordesillas-Gutiérrez, Diana
    FIDMAG Germanes Hospitalàries, Madrid, Spain; Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.
    Trollor, Julian N.
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
    Turner, Jessica A.
    College of Arts and Sciences, Georgia State University, GA, Atlanta, United States.
    Uhlmann, Anne
    Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa.
    van den Heuvel, Odile A.
    Department of Psychiatry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
    van den Meer, Dennis
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands.
    van der Wee, Nic J. A.
    Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands; Leiden Institute for Brain and Cognition, Leiden, Netherlands.
    van Haren, Neeltje E. M.
    Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands.
    van't Ent, Dennis
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    van Erp, Theo G. M.
    Department of Psychiatry, University of California at Irvine, CA, Irvine, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, CA, Irvine, United States; Institute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Greifswald, Germany.
    Veer, Ilya M.
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Veltman, Dick J.
    Department of Psychiatry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
    Voineskos, Aristotle
    Kimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Research Institute, CAMH, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.
    Völzke, Henry
    Institute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany; German Center for Diabetes Research (DZD), partner site Greifswald, Greifswald, Germany.
    Walter, Henrik
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Walton, Esther
    Department of Psychology, University of Bath, Bath, United Kingdom.
    Wang, Lei
    Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, IL, Chicago, United States.
    Wang, Yang
    Department of Radiology, Medical College of Wisconsin, WI, Milwaukee, United States.
    Wassink, Thomas H.
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, IA, Iowa City, United States.
    Weber, Bernd
    Institute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
    Wen, Wei
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
    West, John D.
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    Westlye, Lars T.
    Department of Psychology, University of Oslo, Oslo, Norway.
    Whalley, Heather
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
    Wierenga, Lara M.
    Developmental and Educational Psychology Unit, Institute of Psychology, Leiden University, Leiden, Netherlands.
    Williams, Steven C. R.
    Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Wittfeld, Katharina
    Department of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
    Wolf, Daniel H.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States.
    Worker, Amanda
    Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Wright, Margaret J.
    Queensland Brain Institute, University of Queensland, Brisbane, Australia.
    Yang, Kun
    National High Magnetic Field Laboratory, Florida State University, FL, Tallahassee, United States.
    Yoncheva, Yulyia
    Department of Child and Adolescent Psychiatry, Child Study Center, NYU Langone Health, NY, New York, United States.
    Zanetti, Marcus V.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil.
    Ziegler, Georg C.
    Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Wurzburg, Germany.
    Thompson, Paul M.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States.
    Frangou, Sophia
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York, United States; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
    Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years2022In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 43, no 1, p. 452-469Article in journal (Refereed)
    Abstract [en]

    Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.

    Download full text (pdf)
    fulltext
  • 5.
    Frangou, Sophia
    et al.
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York City, United States; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
    Modabbernia, Amirhossein
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York City, United States.
    Williams, Steven C. R.
    Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Papachristou, Efstathios
    Psychology and Human Development, Institute of Education, University College London, London, United Kingdom.
    Doucet, Gaelle E.
    Institute for Human Neuroscience, Boys Town National Research Hospital, NE, Omaha, United States.
    Agartz, Ingrid
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.
    Aghajani, Moji
    Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, Netherlands; Section Forensic Family & Youth Care, Institute of Education & Child Studies, Leiden University, Netherlands.
    Akudjedu, Theophilus N.
    Institute of Medical Imaging and Visualisation, Department of Medical Science and Public Health, Faculty of Health and Social Sciences, Bournemouth University, Poole, United Kingdom; Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
    Albajes-Eizagirre, Anton
    FIDMAG Germanes Hospitalàries, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Alnæs, Dag
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Alpert, Kathryn I.
    Radiologics, Inc, MO, Saint Louis, United States.
    Andersson, Micael
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Andreasen, Nancy C.
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, IA, Iowa City, United States.
    Andreassen, Ole A.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Asherson, Philip
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Banaschewski, Tobias
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
    Bargallo, Nuria
    Imaging Diagnostic Centre, Hospital Clinic, Barcelona University Clinic, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Barcelona, Spain.
    Baumeister, Sarah
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
    Baur-Streubel, Ramona
    Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Würzburg, Germany.
    Bertolino, Alessandro
    Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
    Bonvino, Aurora
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Boomsma, Dorret I.
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Borgwardt, Stefan
    Department of Psychiatry & Psychotherapy, University of Lübeck, Lübeck, Germany.
    Bourque, Josiane
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States.
    Brandeis, Daniel
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
    Breier, Alan
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    Brodaty, Henry
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Kensington, Australia.
    Brouwer, Rachel M.
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
    Buitelaar, Jan K.
    Donders Center of Medical Neurosciences, Radboud University, Nijmegen, Netherlands; Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
    Busatto, Geraldo F.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Buckner, Randy L.
    Department of Psychology, Center for Brain Science, Harvard University, MA, Cambridge, United States; Department of Psychiatry, Massachusetts General Hospital, MA, Boston, United States.
    Calhoun, Vincent
    Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, USA Neurology, Radiology, Psychiatry and Biomedical Engineering, Emory University, GA, Atlanta, United States.
    Canales-Rodríguez, Erick J.
    FIDMAG Germanes Hospitalàries, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Cannon, Dara M.
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
    Caseras, Xavier
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.
    Castellanos, Francisco X.
    Department of Child and Adolescent Psychiatry, New York University, NY, New York, United States.
    Cervenka, Simon
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Stockholm Health Care Services, Stockholm, Sweden.
    Chaim-Avancini, Tiffany M.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Ching, Christopher R. K.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Marina del Rey, United States.
    Chubar, Victoria
    Mind-Body Research Group, Department of Neuroscience, KU Leuven, Leuven, Belgium.
    Clark, Vincent P.
    Department of Psychology, University of New Mexico, NM, Albuquerque, United States; Mind Research Network, NM, Albuquerque, United States.
    Conrod, Patricia
    Department of Psychiatry, Université de Montréal, Montreal, Canada.
    Conzelmann, Annette
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany.
    Crespo-Facorro, Benedicto
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; HU Virgen del Rocio, IBiS, University of Sevilla, Sevilla, Spain.
    Crivello, Fabrice
    Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Bordeaux, France.
    Crone, Eveline A.
    Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Rotterdam, Netherlands; Faculteit der Sociale Wetenschappen, Instituut Psychologie, Universiteit Leiden, Leiden, Netherlands.
    Dale, Anders M.
    Center for Multimodal Imaging and Genetics, Department of Neuroscience, University of California-San Diego, CA, San Diego, United States; Department of Radiology, University of California-San Diego, CA, San Diego, United States.
    Davey, Cristopher
    Department of Psychiatry, University of Melbourne, Melbourne, Australia.
    de Geus, Eco J. C.
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    de Haan, Lieuwe
    Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
    de Zubicaray, Greig I.
    Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
    den Braber, Anouk
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Dickie, Erin W.
    Kimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Research Institute, CAMH, Campbell, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.
    Di Giorgio, Annabella
    Biological Psychiatry Lab, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
    Doan, Nhat Trung
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Dørum, Erlend S.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
    Ehrlich, Stefan
    Division of Psychological and Social Medicine and Developmental Neurosciences, Technische Universität Dresden, Dresden, Germany; Faculty of Medicine, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany.
    Erk, Susanne
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Espeseth, Thomas
    Department of Psychology, University of Oslo, Oslo, Norway; Bjørknes College, Oslo, Norway.
    Fatouros-Bergman, Helena
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Stockholm Health Care Services, Stockholm, Sweden.
    Fisher, Simon E.
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.
    Fouche, Jean-Paul
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
    Franke, Barbara
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands.
    Frodl, Thomas
    Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.
    Fuentes-Claramonte, Paola
    FIDMAG Germanes Hospitalàries, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Glahn, David C.
    Department of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital, Harvard Medical School, MA, Boston, United States.
    Gotlib, Ian H.
    Department of Psychology, Stanford University, CA, Stanford, United States.
    Grabe, Hans-Jörgen
    Department of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
    Grimm, Oliver
    Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany.
    Groenewold, Nynke A.
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
    Grotegerd, Dominik
    Department of Psychiatry and Psychotherapy, University of Münster, Germany.
    Gruber, Oliver
    Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
    Gruner, Patricia
    Department of Psychiatry, Yale University, CT, New Haven, United States; Learning Based Recovery Center, VA Connecticut Health System, CT, West Haven, United States.
    Gur, Rachel E.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States; Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States; Children's Hospital of Philadelphia, University of Pennsylvania, PA, Philadelphia, United States.
    Gur, Ruben C.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States; Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States; Children's Hospital of Philadelphia, University of Pennsylvania, PA, Philadelphia, United States.
    Harrison, Ben J.
    Melbourne Neuropsychiatry Center, University of Melbourne, Melbourne, Australia.
    Hartman, Catharine A.
    Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
    Hatton, Sean N.
    Brain and Mind Centre, University of Sydney, Sydney, Australia.
    Heinz, Andreas
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Heslenfeld, Dirk J.
    Departments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
    Hibar, Derrek P.
    Personalized Healthcare, Genentech, Inc., CA, South San Francisco, United States.
    Hickie, Ian B.
    Brain and Mind Centre, University of Sydney, Sydney, Australia.
    Ho, Beng-Choon
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, IA, Iowa City, United States.
    Hoekstra, Pieter J.
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
    Hohmann, Sarah
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
    Holmes, Avram J.
    Department of Psychology, Yale University, CT, New Haven, United States.
    Hoogman, Martine
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
    Hosten, Norbert
    Norbert Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, University of Greifswald, Greifswald, Germany.
    Howells, Fleur M.
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
    Hulshoff Pol, Hilleke E.
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
    Huyser, Chaim
    De Bascule, Academic Centre for Children and Adolescent Psychiatry, Amsterdam, Netherlands.
    Jahanshad, Neda
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Marina del Rey, United States.
    James, Anthony
    Department of Psychiatry, Oxford University, Oxford, United Kingdom.
    Jernigan, Terry L.
    Center for Human Development, Departments of Cognitive Science, Psychiatry, and Radiology, University of California, CA, San Diego, United States.
    Jiang, Jiyang
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Kensington, Australia.
    Jönsson, Erik G.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Joska, John A.
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
    Kahn, Rene
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York City, United States.
    Kalnin, Andrew
    Department of Radiology, Ohio State University College of Medicine, OH, Columbus, United States.
    Kanai, Ryota
    Department of Neuroinformatics, Araya, Inc., Tokyo, Japan.
    Klein, Marieke
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands; Department of Psychiatry, University of California San Diego, CA, San Diego, United States.
    Klyushnik, Tatyana P.
    Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation.
    Koenders, Laura
    Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
    Koops, Sanne
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
    Krämer, Bernd
    Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
    Kuntsi, Jonna
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Lagopoulos, Jim
    Sunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Queensland, Australia.
    Lázaro, Luisa
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
    Lebedeva, Irina
    Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation.
    Lee, Won Hee
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, New York City, United States.
    Lesch, Klaus-Peter
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius-Maximilians Universität Würzburg, Würzburg, Germany.
    Lochner, Christine
    SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
    Machielsen, Marise W. J.
    Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
    Maingault, Sophie
    Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Bordeaux, France.
    Martin, Nicholas G.
    Queensland Institute of Medical Research, Berghofer Medical Research Institute, QLD, Australia.
    Martínez-Zalacaín, Ignacio
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.
    Mataix-Cols, David
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Stockholm Health Care Services, Stockholm, Sweden.
    Mazoyer, Bernard
    Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Bordeaux, France.
    McDonald, Colm
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
    McDonald, Brenna C.
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    McIntosh, Andrew M.
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
    McMahon, Katie L.
    School of Clinical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, QLD, Australia.
    McPhilemy, Genevieve
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
    Menchón, José M.
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.
    Medland, Sarah E.
    Queensland Institute of Medical Research, Berghofer Medical Research Institute, QLD, Australia.
    Meyer-Lindenberg, Andreas
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
    Naaijen, Jilly
    Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
    Najt, Pablo
    Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
    Nakao, Tomohiro
    Department of Clinical Medicine, Kyushu University, Fukuoka, Japan.
    Nordvik, Jan E.
    CatoSenteret Rehabilitation Hospital, Son, Norway.
    Nyberg, Lars
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
    Oosterlaan, Jaap
    Department of Clinical Neuropsychology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
    de la Foz, Víctor Ortiz-García
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, University Hospital “Marques de Valdecilla”, Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
    Paloyelis, Yannis
    Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
    Pauli, Paul
    Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Würzburg, Germany; Centre of Mental Health, University of Würzburg, Würzburg, Germany.
    Pergola, Giulio
    Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
    Pomarol-Clotet, Edith
    FIDMAG Germanes Hospitalàries, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
    Portella, Maria J.
    FIDMAG Germanes Hospitalàries, Barcelona, Spain; Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Potkin, Steven G.
    Department of Psychiatry, University of California at Irvine, CA, Irvine, United States.
    Radua, Joaquim
    Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Barcelona, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
    Reif, Andreas
    Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany.
    Rinker, Daniel A.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Roffman, Joshua L.
    Department of Psychiatry, Massachusetts General Hospital, MA, Boston, United States.
    Rosa, Pedro G. P.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Sacchet, Matthew D.
    Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, MA, Boston, United States.
    Sachdev, Perminder S.
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Kensington, Australia.
    Salvador, Raymond
    FIDMAG Germanes Hospitalàries, Barcelona, Spain.
    Sánchez-Juan, Pascual
    Department of Psychiatry, University Hospital “Marques de Valdecilla”, Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo, Spain.
    Sarró, Salvador
    FIDMAG Germanes Hospitalàries, Barcelona, Spain.
    Satterthwaite, Theodore D.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States.
    Saykin, Andrew J.
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    Serpa, Mauricio H.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
    Schmaal, Lianne
    Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
    Schnell, Knut
    Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
    Schumann, Gunter
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
    Sim, Kang
    Department of General Psychiatry, Institute of Mental Health, Singapore, Singapore.
    Smoller, Jordan W.
    Center for Genomic Medicine, Massachusetts General Hospital, MA, Boston, United States.
    Sommer, Iris
    Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, Netherlands.
    Soriano-Mas, Carles
    Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.
    Stein, Dan J.
    SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
    Strike, Lachlan T.
    Queensland Brain Institute, University of Queensland, QLD, Australia.
    Swagerman, Suzanne C.
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    Tamnes, Christian K.
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
    Temmingh, Henk S.
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
    Thomopoulos, Sophia I.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Marina del Rey, United States.
    Tomyshev, Alexander S.
    Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation.
    Tordesillas-Gutiérrez, Diana
    FIDMAG Germanes Hospitalàries, Barcelona, Spain; Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Cantabria, Spain.
    Trollor, Julian N.
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Kensington, Australia.
    Turner, Jessica A.
    College of Arts and Sciences, Georgia State University, GA, Atlanta, United States.
    Uhlmann, Anne
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
    van den Heuvel, Odile A.
    Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, Netherlands.
    van den Meer, Dennis
    Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands.
    van der Wee, Nic J. A.
    Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands; Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, Netherlands.
    van Haren, Neeltje E. M.
    Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands.
    van 't Ent, Dennis
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
    van Erp, Theo G. M.
    Department of Psychiatry, University of California at Irvine, CA, Irvine, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, CA, Irvine, United States; Institute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Greifswald, Germany.
    Veer, Ilya M.
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Veltman, Dick J.
    Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, Netherlands.
    Voineskos, Aristotle
    Kimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Research Institute, CAMH, Campbell, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.
    Völzke, Henry
    Institute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany; German Center for Diabetes Research (DZD), partner site Greifswald, Greifswald, Germany.
    Walter, Henrik
    Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Walton, Esther
    Department of Psychology, University of Bath, Bath, United Kingdom.
    Wang, Lei
    Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, IL, Evanston, United States.
    Wang, Yang
    Department of Radiology, Medical College of Wisconsin, WI, Milwaukee, United States.
    Wassink, Thomas H.
    Department of Psychiatry, Carver College of Medicine, The University of Iowa, IA, Iowa City, United States.
    Weber, Bernd
    Institute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
    Wen, Wei
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Kensington, Australia.
    West, John D.
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, IN, Indianapolis, United States.
    Westlye, Lars T.
    Department of Psychology, University of Oslo, Oslo, Norway.
    Whalley, Heather
    Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
    Wierenga, Lara M.
    Developmental and Educational Psychology Unit, Institute of Psychology, Leiden University, Leiden, Netherlands.
    Wittfeld, Katharina
    Department of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
    Wolf, Daniel H.
    Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States.
    Worker, Amanda
    Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
    Wright, Margaret J.
    Queensland Brain Institute, University of Queensland, QLD, Australia.
    Yang, Kun
    National High Magnetic Field Laboratory, Florida State University, FL, Tallahassee, United States.
    Yoncheva, Yulyia
    Department of Child and Adolescent Psychiatry, Child Study Center, NYU Langone Health, NY, New York City, United States.
    Zanetti, Marcus V.
    Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil.
    Ziegler, Georg C.
    Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
    Thompson, Paul M.
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, CA, Marina del Rey, United States.
    Dima, Danai
    Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Psychology, School of Arts and Social Sciences, City University of London, London, United Kingdom.
    Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years2022In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 43, p. 431-451Article in journal (Refereed)
    Abstract [en]

    Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.

    Download full text (pdf)
    fulltext
  • 6.
    Kaboodvand, Neda
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
    Bäckman, Lars
    Nyberg, Lars
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Salami, Alireza
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
    The retrosplenial cortex: a memory gateway between the cortical default mode network and the medial temporal lobe2018In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 39, no 5, p. 2020-2034Article in journal (Refereed)
    Abstract [en]

    The default mode network (DMN) involves interacting cortical areas, including the posterior cingulate cortex (PCC) and the retrosplenial cortex (RSC), and subcortical areas, including the medial temporal lobe (MTL). The degree of functional connectivity (FC) within the DMN, particularly between MTL and medial-parietal subsystems, relates to episodic memory (EM) processes. However, past resting-state studies investigating the link between posterior DMN-MTL FC and EM performance yielded inconsistent results, possibly reflecting heterogeneity in the degree of connectivity between MTL and specific cortical DMN regions. Animal work suggests that RSC has structural connections to both cortical DMN regions and MTL, and may thus serve as an intermediate layer that facilitates information transfer between cortical and subcortical DMNs. We studied 180 healthy old adults (aged 64-68 years), who underwent comprehensive assessment of EM, along with resting-state fMRI. We found greater FC between MTL and RSC than between MTL and the other cortical DMN regions (e.g., PCC), with the only significant association with EM observed for MTL-RSC FC. Mediational analysis showed that MTL-cortical DMN connectivity increased with RSC as a mediator. Further analysis using a graph-theoretical approach on DMN nodes revealed the highest betweenness centrality for RSC, confirming that a high proportion of short paths among DMN regions pass through RSC. Importantly, the degree of RSC mediation was associated with EM performance, suggesting that individuals with greater mediation have an EM advantage. These findings suggest that RSC forms a critical gateway between MTL and cortical DMN to support EM in older adults.

  • 7.
    Lenfeldt, Niklas
    et al.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Johansson, Anna-Maria
    Umeå University, Faculty of Social Sciences, Department of Psychology. Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy.
    Domellöf, Erik
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Riklund, Katrine
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
    Rönnqvist, Louise
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Alterations in white matter microstructure are associated with goal-directed upper-limb movement segmentation in children born extremely preterm2017In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 38, no 10, p. 5051-5068Article in journal (Refereed)
    Abstract [en]

    Altered white matter microstructure is commonly found in children born preterm (PT), especially those born at an extremely low gestational age (GA). These children also commonly show disturbed motor function. This study explores the relation between white matter alterations and upperlimb movement segmentation in 41 children born PT (19 girls), and 41 children born at term (18 girls) at 8 years. The PT group was subdivided into extremely PT (E-PT; GA = 25–27 weeks, N = 10), very PT (V-PT; GA = 28–32 weeks, N = 13), and moderately PT (M-PT; GA = 33–35 weeks, N = 18). Arm/hand preference (preferred/non-preferred) was determined through object interactions and the brain hemispheres were designated accordingly. White matter alterations were assessed using diffusion tensor imaging in nine areas, and movement segmentation of the body-parts head, shoulder, elbow, and wrist were registered during a unimanual goal-directed task. Increased movement segmentation was demonstrated consistently on the preferred side in the E-PT group compared with the term born group. Also compared with the term born peers, the E-PT group demonstrated reduced fractional anisotropy (FA) in the cerebral peduncle (targeting the corticospinal tract) in the hemisphere on the non-preferred side and in the splenium of corpus callosum. In contrast, in the anterior internal capsule on the preferred side, the E-PT group had increased FA. Lower FA in the cerebral peduncle, but higher FA in the anterior internal capsule, was associated with increased movement segmentation across body-parts in a contralateral manner. The results suggest that impaired development of sensorimotor tracts in E-PT children could explain a sub-optimal spatiotemporal organization of upper-limb movements.

  • 8. Lövdén, Martin
    et al.
    Laukka, Erika Jonsson
    Rieckmann, Anna
    Kalpouzos, Grégoria
    Li, Tie-Qiang
    Jonsson, Tomas
    Wahlund, Lars-Olof
    Fratiglioni, Laura
    Bäckman, Lars
    The dimensionality of between-person differences in white matter microstructure in old age.2013In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 34, no 6, p. 1386-98Article in journal (Refereed)
    Abstract [en]

    Between-person differences in white matter microstructure may partly generalize across the brain and partly play out differently for distinct tracts. We used diffusion-tensor imaging and structural equation modeling to investigate this issue in a sample of 260 adults aged 60-87 years. Mean fractional anisotropy and mean diffusivity of seven white matter tracts in each hemisphere were quantified. Results showed good fit of a model positing that individual differences in white matter microstructure are structured according to tracts. A general factor, although accounting for variance in the measures, did not adequately represent the individual differences. This indicates the presence of a substantial amount of tract-specific individual differences in white matter microstructure. In addition, individual differences are to a varying degree shared between tracts, indicating that general factors also affect white matter microstructure. Age-related differences in white matter microstructure were present for all tracts. Correlations among tract factors did not generally increase as a function of age, suggesting that aging is not a process with homogenous effects on white matter microstructure across the brain. These findings highlight the need for future research to examine whether relations between white matter microstructure and diverse outcomes are specific or general.

  • 9. Ossewaarde, Lindsey
    et al.
    van Wingen, Guido A.
    Rijpkema, Mark
    Bäckström, Torbjörn
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
    Hermans, Erno J.
    Fernandez, Guillen
    Menstrual cycle-related changes in amygdala morphology are associated with changes in stress sensitivity2013In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 34, no 5, p. 1187-1193Article in journal (Refereed)
    Abstract [en]

    Premenstrual increases in negative mood are thought to arise from changes in gonadal hormone levels, presumably by influencing mood regulation and stress sensitivity. The amygdala plays a major role in this context, and animal studies suggest that gonadal hormones influence its morphology. Here, we investigated whether amygdala morphology changes over the menstrual cycle and whether this change explains differences in stress sensitivity. Twenty-eight young healthy women were investigated once during the premenstrual phase and once during the late follicular phase. T1-weighted anatomical images of the brain were acquired using magnetic resonance imaging and analyzed with optimized voxel-based morphometry. To measure mood regulation and stress sensitivity, negative affect was assessed after viewing strongly aversive as well as neutral movie clips. Our results show increased gray matter volume in the dorsal part of the left amygdala during the premenstrual phase when compared with the late follicular phase. This volume increase was positively correlated with the premenstrual increase in stress-induced negative affect. This is the first study showing structural plasticity of the amygdala in humans at the macroscopic level that is associated with both endogenous gonadal hormone fluctuations and stress sensitivity. These results correspond with animal findings of gonadal hormone-mediated neural plasticity in the amygdala and have implications for understanding the pathogenesis of specific mood disorders associated with hormonal fluctuations. Hum Brain Mapp, 2013. (c) 2011 Wiley Periodicals, Inc.

  • 10.
    Persson, Jonas
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Karolinska Inst, ARC, S-11330 Stockholm, Sweden; Stockholm Univ, S-11330 Stockholm, Sweden; Stockholm Univ, Dept Psychol, S-11330 Stockholm, Sweden.
    Rieckmann, Anna
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
    Kalpouzos, Grégoria
    Fischer, Håkan
    Bäckman, Lars
    Influences of a DRD2 polymorphism on updating of long-term memory representations and caudate BOLD activity: magnification in aging2015In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 36, no 4, p. 1325-1334Article in journal (Refereed)
    Abstract [en]

    A number of genetic polymorphisms are related to individual differences in cognitive performance. Striatal dopamine (DA) functions, associated with cognitive performance, are linked to the TaqIA polymorphism of the DRD2/ANKK1 gene. In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIA polymorphism is related to reduced density of striatal DA D2 receptors. The resource-modulation hypothesis assumes that aging-related losses of neurochemical and structural brain resources modulate the extent to which genetic variations affect cognitive functioning. Here, we tested this hypothesis using functional MRI during long-term memory (LTM) updating in younger and older carriers and noncarriers of the A1-allele of the TaqIa polymorphism. We demonstrate that older A1-carriers have worse memory performance, specifically during LTM updating, compared to noncarriers. Moreover, A1-carriers exhibited less blood oxygen level-dependent (BOLD) activation in left caudate nucleus, a region critical to updating. This effect was only seen in older adults, suggesting magnification of genetic effects on functional brain activity in aging. Further, a positive relationship between caudate BOLD activation and updating performance among non-A1 carriers indicated that caudate activation was behaviorally relevant. These results demonstrate a link between the DRD2/ANKK1-TaqIA polymorphism and neurocognitive deficits related to LTM updating, and provide novel evidence that this effect is magnified in aging. Hum Brain Mapp 36:1325-1334, 2015.

  • 11.
    Rieckmann, Anna
    et al.
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
    Hedden, Trey
    Younger, Alayna P
    Sperling, Reisa A
    Johnson, Keith A
    Buckner, Randy L
    Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity2016In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 37, no 2, p. 621-631Article in journal (Refereed)
    Abstract [en]

    Aging-related differences in white matter integrity, the presence of amyloid plaques, and density of biomarkers indicative of dopamine functions can be detected and quantified with in vivo human imaging. The primary aim of the present study was to investigate whether these imaging-based measures constitute independent imaging biomarkers in older adults, which would speak to the hypothesis that the aging brain is characterized by multiple independent neurobiological cascades. We assessed MRI-based markers of white matter integrity and PET-based marker of dopamine transporter density and amyloid deposition in the same set of 53 clinically normal individuals (age 65-87). A multiple regression analysis demonstrated that dopamine transporter availability is predicted by white matter integrity, which was detectable even after controlling for chronological age. Further post-hoc exploration revealed that dopamine transporter availability was further associated with systolic blood pressure, mirroring the established association between cardiovascular health and white matter integrity. Dopamine transporter availability was not associated with the presence of amyloid burden. Neurobiological correlates of dopamine transporter measures in aging are therefore likely unrelated to Alzheimer's disease but are aligned with white matter integrity and cardiovascular risk. More generally, these results suggest that two common imaging markers of the aging brain that are typically investigated separately do not reflect independent neurobiological processes.

  • 12. Wierenga, Lara M.
    et al.
    Doucet, Gaelle E.
    Dima, Danai
    Agartz, Ingrid
    Aghajani, Moji
    Akudjedu, Theophilus N.
    Albajes-Eizagirre, Anton
    Alnaes, Dag
    Alpert, Kathryn, I
    Andreassen, Ole A.
    Anticevic, Alan
    Asherson, Philip
    Banaschewski, Tobias
    Bargallo, Nuria
    Baumeister, Sarah
    Baur-Streubel, Ramona
    Bertolino, Alessandro
    Bonvino, Aurora
    Boomsma, Dorret, I
    Borgwardt, Stefan
    Bourque, Josiane
    den Braber, Anouk
    Brandeis, Daniel
    Breier, Alan
    Brodaty, Henry
    Brouwer, Rachel M.
    Buitelaar, Jan K.
    Busatto, Geraldo F.
    Calhoun, Vince D.
    Canales-Rodriguez, Erick J.
    Cannon, Dara M.
    Caseras, Xavier
    Castellanos, Francisco X.
    Chaim-Avancini, Tiffany M.
    Ching, Christopher R. K.
    Clark, Vincent P.
    Conrod, Patricia J.
    Conzelmann, Annette
    Crivello, Fabrice
    Davey, Christopher G.
    Dickie, Erin W.
    Ehrlich, Stefan
    Van't Ent, Dennis
    Fisher, Simon E.
    Fouche, Jean-Paul
    Franke, Barbara
    Fuentes-Claramonte, Paola
    de Geus, Eco J. C.
    Di Giorgio, Annabella
    Glahn, David C.
    Gotlib, Ian H.
    Grabe, Hans J.
    Gruber, Oliver
    Gruner, Patricia
    Gur, Raquel E.
    Gur, Ruben C.
    Gurholt, Tiril P.
    de Haan, Lieuwe
    Haatveit, Beathe
    Harrison, Ben J.
    Hartman, Catharina A.
    Hatton, Sean N.
    Heslenfeld, Dirk J.
    van den Heuvel, Odile A.
    Hickie, Ian B.
    Hoekstra, Pieter J.
    Hohmann, Sarah
    Holmes, Avram J.
    Hoogman, Martine
    Hosten, Norbert
    Howells, Fleur M.
    Pol, Hilleke E. Hulshoff
    Huyser, Chaim
    Jahanshad, Neda
    James, Anthony C.
    Jiang, Jiyang
    Jonsson, Erik G.
    Joska, John A.
    Kalnin, Andrew J.
    Klein, Marieke
    Koenders, Laura
    Kolskar, Knut K.
    Kramer, Bernd
    Kuntsi, Jonna
    Lagopoulos, Jim
    Lazaro, Luisa
    Lebedeva, Irina S.
    Lee, Phil H.
    Lochner, Christine
    Machielsen, Marise W. J.
    Maingault, Sophie
    Martin, Nicholas G.
    Martinez-Zalacain, Ignacio
    Mataix-Cols, David
    Mazoyer, Bernard
    McDonald, Brenna C.
    McDonald, Colm
    McIntosh, Andrew M.
    McMahon, Katie L.
    McPhilemy, Genevieve
    van der Meer, Dennis
    Menchon, Jose M.
    Naaijen, Jilly
    Nyberg, Lars
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Oosterlaan, Jaap
    Paloyelis, Yannis
    Pauli, Paul
    Pergola, Giulio
    Pomarol-Clotet, Edith
    Portella, Maria J.
    Radua, Joaquim
    Reif, Andreas
    Richard, Genevieve
    Roffman, Joshua L.
    Rosa, Pedro G. P.
    Sacchet, Matthew D.
    Sachdev, Perminder S.
    Salvador, Raymond
    Sarro, Salvador
    Satterthwaite, Theodore D.
    Saykin, Andrew J.
    Serpa, Mauricio H.
    Sim, Kang
    Simmons, Andrew
    Smoller, Jordan W.
    Sommer, Iris E.
    Soriano-Mas, Carles
    Stein, Dan J.
    Strike, Lachlan T.
    Szeszko, Philip R.
    Temmingh, Henk S.
    Thomopoulos, Sophia, I
    Tomyshev, Alexander S.
    Trollor, Julian N.
    Uhlmann, Anne
    Veer, Ilya M.
    Veltman, Dick J.
    Voineskos, Aristotle
    Volzke, Henry
    Walter, Henrik
    Wang, Lei
    Wang, Yang
    Weber, Bernd
    Wen, Wei
    West, John D.
    Westlye, Lars T.
    Whalley, Heather C.
    Williams, Steven C. R.
    Wittfeld, Katharina
    Wolf, Daniel H.
    Wright, Margaret J.
    Yoncheva, Yuliya N.
    Zanetti, Marcus, V
    Ziegler, Georg C.
    de Zubicaray, Greig, I
    Thompson, Paul M.
    Crone, Eveline A.
    Frangou, Sophia
    Tamnes, Christian K.
    Greater male than female variability in regional brain structure across the lifespan2022In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 43, no 1, p. 470-499Article in journal (Refereed)
    Abstract [en]

    For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

    Download full text (pdf)
    fulltext
  • 13. Zuo, Nianming
    et al.
    Salami, Alireza
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Aging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden.
    Yang, Yihong
    Yang, Zhengyi
    Sui, Jing
    Jian, Tianzi
    Activation-based association profiles differentiate network roles across cognitive loads2019In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 40, no 9, p. 2800-2812Article in journal (Refereed)
    Abstract [en]

    Working memory (WM) is a complex and pivotal cognitive system underlying the performance of many cognitive behaviors. Although individual differences in WM performance have previously been linked to the blood oxygenation level-dependent (BOLD) response across several large-scale brain networks, the unique and shared contributions of each large-scale brain network to efficient WM processes across different cognitive loads remain elusive. Using a WM paradigm and functional magnetic resonance imaging (fMRI) from the Human Connectome Project, we proposed a framework to assess the association and shared-association strength between imaging biomarkers and behavioral scales. Association strength is the capability of individual brain regions to modulate WM performance and shared-association strength measures how different regions share the capability of modulating performance. Under higher cognitive load (2-back), the frontoparietal executive control network (FPN), dorsal attention network (DAN), and salience network showed significant positive activation and positive associations, whereas the default mode network (DMN) showed the opposite pattern, namely, significant deactivation and negative associations. Comparing the different cognitive loads, the DMN and FPN showed predominant associations and globally shared-associations. When investigating the differences in association from lower to higher cognitive loads, the DAN demonstrated enhanced association strength and globally shared-associations, which were significantly greater than those of the other networks. This study characterized how brain regions individually and collaboratively support different cognitive loads.

1 - 13 of 13
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf