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  • 1. Saccon, Elisa
    et al.
    Chen, Xi
    Mikaeloff, Flora
    Rodriguez, Jimmy Esneider
    Szekely, Laszlo
    Vinhas, Beatriz Sa
    Krishnan, Shuba
    Byrareddy, Siddappa N.
    Frisan, Teresa
    Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
    Vegvari, Akos
    Mirazimi, Ali
    Neogi, Ujjwal
    Gupta, Soham
    Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-22021In: iScience, E-ISSN 2589-0042 , Vol. 24, no 5, article id 102420Article in journal (Refereed)
    Abstract [en]

    The commonly used laboratory cell lines are the first line of experimental models to study the pathogenicity and performing antiviral assays for emerging viruses. Here, we assessed the tropism and cytopathogenicity of the first Swedish isolate of SARS-CoV-2 in six different human cell lines, compared their growth characteristics, and performed quantitative proteomics for the susceptible cell lines. Overall, Calu-3, Caco2, Huh7, and 293FT cell lines showed a high-to-moderate level of susceptibility to SARS-CoV-2. In Caco2 cells, the virus can achieve high titers in the absence of any prominent cytopathic effect. The protein abundance profile during SARS-CoV-2 infection revealed cell-type-specific regulation of cellular pathways. Type-I interferon signaling was identified as the common dysregulated cellular response in Caco2, Calu-3, and Huh7 cells. Together, our data show cell-type specific variability for cytopathogenicity, susceptibility, and cellular response to SARS-CoV-2 and provide important clues to guide future studies.

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