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  • 1.
    Achour, Cyrinne
    et al.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
    Bhattarai, Devi Prasad
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Esteva-Socias, Margalida
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Rodriguez-Barrueco, Ruth
    Malla, Sandhya
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
    Seier, Kerstin
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
    Marchand, Virginie
    Motorine, Yuri
    Lundin, Eva
    Umeå University, Faculty of Medicine, Department of Medical Biosciences.
    Gilthorpe, Jonathan D.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Marzese, Diego Matias
    Bally, Marta
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
    Roman, Angel-Carlos
    Pich, Andreas
    Aguilo, Francesca
    Reshaping the role of METTL3 in breast tumorigenesisManuscript (preprint) (Other academic)
  • 2.
    Cerón-Pisa, Noemi
    et al.
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
    Iglesias, Amanda
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación Biomédica en Red in Respiratory Diseases (CIBERES), Madrid, Spain.
    Shafiek, Hanaa
    Chest Diseases Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
    Martín-Medina, Aina
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
    Esteva-Socias, Margalida
    Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Muncunill, Josep
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
    Fleischer, Aarne
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
    Verdú, Javier
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain; Respiratory Medicine, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
    Cosío, Borja G.
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación Biomédica en Red in Respiratory Diseases (CIBERES), Madrid, Spain; Respiratory Medicine, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
    Sauleda, Jaume
    Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación Biomédica en Red in Respiratory Diseases (CIBERES), Madrid, Spain; Respiratory Medicine, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
    Hsa-Mir-320c, Hsa-Mir-200c-3p, and Hsa-Mir-449c-5p as Potential Specific miRNA Biomarkers of COPD: A Pilot Study2022In: Pathophysiology, ISSN 0928-4680, E-ISSN 1873-149X, Vol. 29, no 2, p. 143-157Article in journal (Refereed)
    Abstract [en]

    Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease commonly induced by cigarette smoke. The expression of miRNAs can be altered in patients with COPD and could be used as a biomarker. We aimed to identify a panel of miRNAs in bron-choalveolar lavage (BAL) to differentiate COPD patients from smokers and non-smokers with normal lung function. Accordingly, forty-five subjects classified as COPD, smokers, and non-smokers (n = 15 per group) underwent clinical, functional characterization and bronchoscopy with BAL. The mean age of the studied population was 61.61 ± 12.95 years, BMI 25.72 ± 3.82 Kg/m2, FEV1/FVC 68.37 ± 12.00%, and FEV1 80.07 ± 23.63% predicted. According to microarray analysis, three miRNAs of the most upregulated were chosen: miR-320c, miR-200c-3p, and miR-449c-5p. These miRNAs were validated by qPCR and were shown to be differently expressed in COPD patients. ROC analysis showed that these three miRNAs together had an area under the curve of 0.89 in differentiating COPD from controls. Moreover, in silico analysis of candidate miRNAs by DIANA-miRPath showed potential involvement in the EGFR and Hippo pathways. These results suggest a specific 3-miRNA signature that could be potentially used as a biomarker to distinguish COPD patients from smokers and non-smoker subjects.

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  • 3.
    Esteva-Socias, Margalida
    et al.
    Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Aguilo, Francesca
    Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    METTL3 as a master regulator of translation in cancer: mechanisms and implications2024In: NAR Cancer, E-ISSN 2632-8674, Vol. 6, no 1, article id zcae009Article in journal (Refereed)
    Abstract [en]

    Translational regulation is an important step in the control of gene expression. In cancer cells, the orchestration of both global control of protein synthesis and selective translation of specific mRNAs promote tumor cell survival, angiogenesis, transformation, invasion and metastasis. N6-methyladenosine (m6A), the most prevalent mRNA modification in higher eukaryotes, impacts protein translation. Over the past decade, the development of m6A mapping tools has facilitated comprehensive functional investigations, revealing the involvement of this chemical mark, together with its writer METTL3, in promoting the translation of both oncogenes and tumor suppressor transcripts, with the impact being context-dependent. This review aims to consolidate our current understanding of how m6A and METTL3 shape translation regulation in the realm of cancer biology. In addition, it delves into the role of cytoplasmic METTL3 in protein synthesis, operating independently of its catalytic activity. Ultimately, our goal is to provide critical insights into the interplay between m6A, METTL3 and translational regulation in cancer, offering a deeper comprehension of the mechanisms sustaining tumorigenesis.

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    fulltext
1 - 3 of 3
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