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  • 1. Andersson, Per
    et al.
    Sjöberg, Rickard L
    Krysa, Marzena
    Sidorowicz, Władysław
    Ohrvik, John
    Leppert, Jerzy
    Lags in behavioral change: A population based comparison of cardiovascular risk behavior in Poland and Sweden.2006Ingår i: Central European Journal of Public Health, ISSN 1210-7778, E-ISSN 1803-1048, Vol. 14, nr 2Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    One thousand and twenty Polish men and women and 1,011 Swedish men and women aged 50 and recruited through primary health care took part in a survey relating to their knowledge of health-related behaviour, attitudes to health-related behaviour and self-reported risk behaviour. The results reveal that Poles know as much about cardiovascular risk factors as Swedes, but that Swedes feel that it is more important to change their dietary habits and to influence factors in the working environment to avoid the risk of developing CVD than did Poles. Swedes also displayed less risk behaviour than Poles and more Swedes than Poles had successfully stopped smoking. These findings suggest that differences in stages of health-related behavior that have previously been observed at an individual level may sometimes also be discerned at a national level.

  • 2. Andersson, Per
    et al.
    Sjöberg, Rickard L
    Ohrvik, John
    Leppert, Jerzy
    Knowledge about cardiovascular risk factors among obese individuals.2006Ingår i: European Journal of Cardiovascular Nursing, ISSN 1474-5151, E-ISSN 1873-1953, Vol. 5, nr 4Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Obesity is an important biological risk factor for cardiovascular disease (CVD).

    AIMS: The main aim of this study was to answer the question whether obese individuals differ from individuals with normal weight with regard to knowledge about risk factors for CVD. A further aim was to replicate previous findings that obese individuals are at higher risk of developing other biological risk factors for CVD.

    METHOD: Normal weights, BMI<25 kg/m(2) (n=385), and obese, BMI> or =30 kg/m(2) (n=159), individuals were identified from a screening program conducted among 50-year-old inhabitants of the County of Västmanland, Sweden. Participants answered questions regarding their gender, level of education, and items relating to knowledge about cardiovascular risk factors. Total cholesterol and blood glucose levels, height, weight and blood pressure were measured.

    RESULTS: Obese individuals did not differ significantly from individuals with a normal weight regarding knowledge of cardiovascular risk factors when education was controlled for. Obesity and low level of education are associated with other risk factors for CVD such as high blood pressure and high serum cholesterol.

    CONCLUSION: Obese individuals are at an increased risk of developing other risk factors for CVD but are just as knowledgeable about risk factors for CVD as normal weighting individuals.

  • 3. Andersson, Per
    et al.
    Sjöberg, Rickard L
    Ohrvik, John
    Leppert, Jerzy
    The effects of family history and personal experiences of illness on the inclination to change health-related behaviour.2009Ingår i: Central European Journal of Public Health, ISSN 1210-7778, E-ISSN 1803-1048, Vol. 17, nr 1Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of the present study was to examine how a personal experience of illness and a family history of cardiovascular disease (CVD), adjusted for sex, level of education and nationality, affect risk behaviour. Participants were 1,011 and 1,043, 50-year-old men and women from Sweden and Poland, respectively, who were recruited from a primary health care screening programme. Family history, personal experience of illness and risk behaviour (smoking and exercise habits, BMI level) were self-reported. The results showed that smoking behaviour was affected by a personal experience of illness but not by a family history of CVD. No effects of these variables were found on the remaining risk-related variables tested in this study. These results suggest that individuals with a personal experience of illness may be more inclined to change smoking behaviour than the average person. Smoking prevention strategies may therefore benefit from targeting this group in particular.

  • 4.
    Bartek, Jiri
    et al.
    Karolinska Universitetssjukhuset, Solna, Sverige.
    Nittby-Redebrandt, Henrietta
    Skånes universitetssjukhus, Lund, Sverige.
    Sjöberg, Rickard L.
    Norrlands universitetssjukhus, Umeå, Sverige.
    Milos, Peter
    Universitetssjukhuset i Linköping, Linköping, Sverige.
    Hesselager, Göran
    Akademiska sjukhuset, Uppsala, Sverige.
    Jakola, Asgeir S.
    Sahlgrenska universitetssjukhuset, Göteborg, Sverige.
    Neurokirurgin alltjämt kärnan i behandlingen av hjärntumörer: [Neurosurgery still pivotal in the diagnostics and treatment of brain tumor patients]2023Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 120, artikel-id 22100Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    Behandling av hjärntumörer görs i samverkan mellan flera medicinska discipliner: neurokirurgi, onkologi, neurologi, neuropatologi, neuroradiologi och rehabiliteringsmedicin.

    Symtom som talar för förhöjt intrakraniellt tryck, såsom kraftig huvudvärk, illamående, kräkningar och papillödem, bör leda till snabb utredning och kontakt med neurokirurg. 

    Förbättrad preoperativ kartläggning av tumören samt angränsande anatomiska och funktionella hjärnområden tillsammans med avancerad mikrokirurgisk teknik, intraoperativ monitorering och visualisering samt nya minimalinvasiva tekniker gör operationer säkrare, och det är i dag möjligt att utföra ingrepp som tidigare ansågs omöjliga eller alltför riskabla.

  • 5.
    Björkblom, Benny
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Wibom, Carl
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Eriksson, Maria
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Bergenheim, A. Tommy
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Jonsson, Pär
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Brännström, Thomas
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Antti, Henrik
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Sandström, Maria
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Melin, Beatrice S.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Distinct metabolic hallmarks of WHO classified adult glioma subtypes2022Ingår i: Neuro-Oncology, ISSN 1522-8517, E-ISSN 1523-5866, Vol. 24, nr 9, s. 1454-1468, artikel-id noac042Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Gliomas are complex tumors with several genetic aberrations and diverse metabolic programs contributing to their aggressive phenotypes and poor prognoses. This study defines key metabolic features that can be used to differentiate between glioma subtypes, with potential for improved diagnostics and subtype targeted therapy.

    METHODS: Cross-platform global metabolomic profiling coupled with clinical, genetic, and pathological analysis of glioma tissue from 224 tumors - oligodendroglioma (n=31), astrocytoma (n=31) and glioblastoma (n=162) - were performed. Identified metabolic phenotypes were evaluated in accordance with the WHO classification, IDH-mutation, 1p/19q-codeletion, WHO-grading 2-4, and MGMT promoter methylation.

    RESULTS: Distinct metabolic phenotypes separate all six analyzed glioma subtypes. IDH-mutated subtypes, expressing 2-hydroxyglutaric acid, were clearly distinguished from IDH-wildtype subtypes. Considerable metabolic heterogeneity outside of the mutated IDH pathway were also evident, with key metabolites being high expression of glycerophosphates, inositols, monosaccharides and sugar alcohols and low levels of sphingosine and lysoglycerophospholipids in IDH-mutants. Among the IDH-mutated subtypes, we observed high levels of amino acids, especially glycine and 2-aminoadipic acid, in grade 4 glioma, and N-acetyl aspartic acid in low-grade astrocytoma and oligodendroglioma. Both IDH-wildtype and mutated oligodendroglioma and glioblastoma were characterized by high levels of acylcarnitines, likely driven by rapid cell growth and hypoxic features. We found elevated levels of 5-HIAA in gliosarcoma and a subtype of oligodendroglioma not yet defined as a specific entity, indicating a previously not described role for the serotonin pathway linked to glioma with bimorphic tissue.

    CONCLUSION: Key metabolic differences exist across adult glioma subtypes.

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  • 6.
    Blomstedt, Patric
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
    Sjöberg, Richard
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
    Hansson, Maja
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
    Bodlund, Owe
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
    Hariz, Marwan I
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
    Deep brain stimulation in the treatment of depression2011Ingår i: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 123, nr 1, s. 4-11Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective:  To present the technique of deep brain stimulation (DBS) and to evaluate the studies conducted on DBS in the treatment of therapy-refractory major depressive disorder (MDD).

    Method:  A review of the literature on DBS in the treatment of MDD was conducted.

    Results:  The results of DBS in MDD have been presented in 2 case reports and 3 studies of 47 patients operated upon in 5 different target areas. Positive effects have been presented in all studies and side effects have been minor. DBS in the nucleus accumbens resulted in a mean reduction of Hamilton depression rating scale (HDRS) of 36% after 1 year and 30% of the 10 patients achieved remission. DBS in the internal capsule/ventral striatum resulted in a reduction of 44% after 1 year, and at the last evaluation after in mean 2 years, 40% of the 15 patients were in remission. The 20 patients with subcallosal cingulated gyrus DBS had a reduction of HDRS of 52% after 1 year, and 35% were within 1 point from remission or in remission.

    Conclusion:  DBS is a promising treatment for therapy-refractory MDD. The published experience is, however, limited, and the method is at present an experimental therapy.

  • 7.
    Blomstedt, Patric
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Sjöberg, Rickard L
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Hansson, Maja
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri. University Hospital of Umeå.
    Bodlund, Owe
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri. University Hospital of Umeå.
    Hariz, Marwan I
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Deep brain stimulation in the treatment of obsessive-compulsive disorder2013Ingår i: World Neurosurgery, ISSN 1878-8750, E-ISSN 1878-8769, Vol. 80, nr 6, s. e245-e253Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Deep brain stimulation (DBS) has emerged as a treatment for severe cases of therapy-refractory obsessive-compulsive disorder (OCD), and promising results have been reported. The literature might, however, be somewhat unclear, considering the different targets used, and due to repeated inclusion of individual patients in multiple publications. The aim of this report was to review the literature on DBS for OCD.

    METHODS: The modern literature concerning studies conducted on DBS in the treatment of OCD was reviewed.

    RESULTS: The results of DBS in OCD have been presented in 25 reports with 130 patients, of which, however, only 90 contained individual patients. Five of these reports included at least 5 individual patients not presented elsewhere. Sixty-eight of these patients underwent implantation in the region of the internal capsule/ventral striatum, including the nucleus accumbens. The target in this region has varied between groups and over time, but the latest results from bilateral procedures in this area have shown a 50% reduction of OCD scores, depression, and anxiety. The subthalamic nucleus has been suggested as an alternative target. Although beneficial effects have been demonstrated, the efficacy of this procedure cannot be decided, because only results after 3 months of active stimulation have been presented so far.

    CONCLUSIONS: DBS is a promising treatment for therapy-refractory OCD, but the published experience is limited and the method is at present an experimental therapy.

  • 8.
    Edström, Sonja
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Numan Hellquist, Barbro
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Sandström, Maria
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Sadanandan, Sajna Anand
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Björkblom, Benny
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Melin, Beatrice
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Sjöberg, Rickard L
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Antidepressants and survival in glioma: a registry-based retrospective cohort study2024Ingår i: Neuro-Oncology Practice, ISSN 2054-2577, E-ISSN 2054-2585, Vol. 11, nr 2, s. 125-131Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Depression and treatment with antidepressant medication is common in patients with malignant glioma. However, the extent to which antidepressants may affect the disease is not fully understood. Therefore, the purpose of the present study was to investigate possible associations between treatment with antidepressant medication and survival in glioma patients.

    Methods: We performed a registry-based cohort study including 1231 patients with malignant glioma (WHO grade 2, 3 and 4) having undergone surgery, and 6400 matched controls without glioma. All data was extracted from the RISK North database, which contains information from multiple national population-based registries in Sweden.

    Results: Treatment with antidepressants is more common in patients with malignant glioma (27%), compared to controls (16%), p<.001. Treatment with antidepressants after surgery for glioma was significantly associated with poorer survival. These effects were observed both for selective serotonin reuptake inhibitors (SSRIs) and non-SSRIs. In grade 4 glioma, SSRI treatment was associated with a HR of 3.32 (95% CI 2.69–4.10, p<.001), and non-SSRI treatment a HR of 3.54 (95% CI 2.52–4.99, p<.001), compared to glioma patients without antidepressants. In grade 2-3 glioma, the HR for SSRI treatment was 3.26 (95% CI 2.19–4.85, p<.001), and for non-SSRI treatment 7.71 (95% CI 4.22-14.12, p<.001).

    Conclusions: Our results demonstrate a negative association between antidepressant medication and survival in glioma. Further research will be needed to clarify causation.

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  • 9.
    Fytagoridis, Anders
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Sjöberg, Richard
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Åström, Mattias
    Fredricks, Anna
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Nyberg, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Fysiologi.
    Blomstedt, Patric
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Effects of deep brain stimulation in the caudal Zona incerta on verbal fluency2013Ingår i: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 91, nr 1, s. 24-29Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Deep brain stimulation (DBS) of the caudal zona incerta (cZi) is a relatively unexplored and promising treatment in patients with severe essential tremor (ET). Preliminary data further indicate that the ability to produce language may be slightly affected by the treatment.

    Objective: To evaluate the effects on verbal fluency following cZi DBS in patients with ET.

    Method: Seventeen consecutive patients who had undergone DBS of the cZi for ET were tested regarding verbal fluency before surgery, 3 days after surgery and after 1 year. Ten patients were also evaluated by comparing performance on versus off stimulation after 1 year.

    Results: The total verbal fluency score decreased slightly, but significantly, from 22.7 (SD = 10.9) before surgery to 18.1 (SD = 7.5) 3 days after surgery (p = 0.036). After 1 year the score was nonsignificantly decreased to 20.1 (SD = 9.7, p = 0.2678). There was no detectable difference between stimulation on and off after 1 year.

    Conclusion: There was a tendency of an immediate and mostly transient postoperative decline in verbal fluency following cZi DBS for ET. In some of the patients this reduction was, however, more pronounced and also sustained over time.

  • 10.
    Johansson, Conny
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Koskinen, Lars-Owe D.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Lindvall, Peter
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Serum Levels of Myo-inositol Predicts Clinical Outcome 1 Year After Aneurysmal Subarachnoid Hemorrhage2022Ingår i: Neurosurgery, ISSN 0148-396X, E-ISSN 1524-4040, Vol. 91, nr 5, s. 790-798Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Early prognostication of long-term outcome in patients suffering from spontaneous subarachnoid hemorrhage (SAH) remains a challenge. No biomarkers are routinely used for prognostication. A previous study has indicated that the metabolite myo-inositol (MI) may be used to predict long-term outcome.

    OBJECTIVE: To investigate if MI measured in serum correlates with long-term clinical outcome in patients suffering from SAH.

    METHODS: We conducted an observational cohort study including 88 patients treated for SAH at Umeå University Hospital. Serum samples were collected in the hospital, and a gas chromatography/mass spectroscopy method was used to quantitatively measure MI. Patients were assessed after 1 year using the Glasgow Outcome Scale Extended and dichotomized to favorable or unfavorable outcome. Differences in MI levels between the 2 groups were analyzed.

    RESULTS: There was no difference in MI levels between the groups upon admission. Myo-inositol levels decreased over time in the entire study population. The decrease was significantly larger in the unfavorable outcome group. A receiver operating characteristics analysis yielded an area under the curve of 0.903 (CI 0.8-1.0, P < .001) for the MI value on day 7 to predict favorable outcome after 1 year.

    CONCLUSION: Myo-inositol measured in serum may aid prognostication of outcome in patients with SAH. The mechanism behind this remains unclear, although it can be theorized to reflect processes leading to delayed cerebral ischemia, which affects long-term outcome. This is the first study to quantitively measure MI in serum for prognostication of outcome in patients with SAH.

  • 11.
    Koskinen, Lars-Owe D.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Blomstedt, Patric
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Predicting improvement after surgery for palmar hyperhidrosis2012Ingår i: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 126, nr 5, s. 324-328Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives Endoscopic transthoracic sympathectomy (ETS) is a surgical procedure used to improve Quality of Life (QoL) in patients with treatment resistant palmar hyperhidrosis (PHH). The aim of this study was to test the hypothesis that low preoperative scores on The Everyday Life Questionnaire (EDLQ) would predict QoL improvement after surgery. Materials and methods Pre- and post-operative QoL scores from a series of 30 consecutive patients who underwent ETS at our institution were analyzed. Results Preoperative QoL scores was a significant predictor of post-operative improvement across all dimensions covered by the questionnaire. Conclusion Preoperative low QoL can be used as a guide in selecting patients with most improved QoL after ETS.

  • 12.
    Larsson, Anneli S.
    et al.
    Göteborgs universitet.
    Sjöberg, Rickard LUmeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Barnförhör: att få vetenskap och juridik att fungera i praktiken2022Samlingsverk (redaktörskap) (Refereegranskat)
    Abstract [sv]

    För ett kvartssekel sedan var själva idén att bygga barnförhör på forskningsbaserad kunskap kontroversiell, inte minst i Sverige. Men i dag är det för de flesta involverade i barnrättsliga frågor en självklarhet att vetenskaplig kunskap om barnförhör, utbildning i barnförhör och barnförhörets praktik måste gå hand i hand. Den här boken är baserad på det perspektivet, ett synsätt som ligger i linje med barnkonventionen och dess krav på myndigheter att hålla ett barnrättsperspektiv.

    Bokens yttersta syfte är att erbjuda kunskap om hur man på bästa sätt bör navigera i multidisciplinär samverkan med verklighets­baserad vetenskaplighet och "sunt förnuft". Teorin kompletteras med praktiska verktyg: handfasta exempel för studerande och intervjustöd för praktiker i deras yrkesutövande.

    Barnförhör vänder sig till studerande och yrkesverksamma inom polis och rättsväsende, socialtjänst, hälso- och sjukvård och i skolvärlden. Den riktar sig även till andra som deltar i diskussioner kring samtal med barn och/eller arbetar med barnutredningar och multidisciplinär samverkan, till exempel på barnahus.

  • 13. Lindholm, Torun
    et al.
    Sjöberg, Rickard L
    Pedroletti, Christophe
    Boman, Anders
    Olsson, Gunnar L
    Sund, Anna
    Lindblad, Frank
    Infants' and toddlers' remembering and forgetting of a stressful medical procedure.2009Ingår i: Journal of Pediatric Psychology, ISSN 0146-8693, E-ISSN 1465-735X, Vol. 34, nr 2Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: To examine whether a distressing medical procedure leaves lasting impressions in young children's memories.

    METHODS: Children 12- to 78-weeks old (N = 172) received inhalation treatment through a face mask or underwent other interventions at a pediatric emergency department. They were randomized to be presented with neutral cues and cues from the inhalation 1 week or 6 months after the target event. Children's reactions at cue presentation were scored from videotapes.

    RESULTS: Across the age span tested, children treated with inhalation showed higher distress than controls when presented with cues from inhalation 1 week, but not 6 months after target treatment.

    CONCLUSIONS: Stress during medical procedures in preverbal children may develop as a result of prior experience of such procedures. These memories typically seem to fade within 6 months.

  • 14. Lindholm, Torun
    et al.
    Sjöberg, Rickard
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Memon, Amina
    Misreporting signs of child abuse: The role of decision-making and outcome information2014Ingår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 55, nr 1, s. 1-9Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Two studies provided evidence that a decision to report an ambiguous case of child abuse affected subsequent memory of the case information, such that participants falsely recognized details that were not presented in the original information, but that are schematically associated with child abuse. Moreover, post-decision information that the child had later died from abuse influenced the memory reports of participants who had chosen not to report the case, increasing their reports of false schema-consistent details. This suggests that false decision-consistent memories are primarily due to sense-making, schematic processing rather than the motivation to justify the decision. The present findings points to an important mechanism by which decision information can become distorted in retrospect, and emphasize the difficulties of improving future decision-making by contemplating past decisions. The results also indicate that decisions may generate false memories in the apparent absence of external suggestion or misleading information. Implications for decision-making theory, and applied practices are discussed.

  • 15.
    Lindsten, Hans
    et al.
    Norrlands universitetssjukhus, Umeå, Sverige.
    Lindvall, Peter
    Norrlands universitetssjukhus, Umeå, Sverige.
    Sjöberg, Rickard L
    Norrlands universitetssjukhus, Umeå, Sverige.
    [DN Debatt repliker] ”Beslutet att centralisera epilepsivården drivs inte av omsorg om patienten”2023Ingår i: Dagens Nyheter, ISSN 1101-2447Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
    Abstract [sv]

    Tre överläkare i neurokirurgi och neurologi: Nivåstruktureringsprocessen inom epilepsikirurgiområdet behöver avbrytas oberoende av om Karolinska drabbas av den eller ej.

  • 16.
    Malmberg, Charlotte
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Numan Hellquist, Barbro
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Sadanandan, Sajna Anand
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Sandström, Maria
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Wu, Wendy Yi-Ying
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Björkblom, Benny
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Melin, Beatrice S.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Sjöberg, Rickard L
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Antidepressant drugs and risk of developing glioma: a national registry-based case control study and a meta-analysis2024Ingår i: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of the present study was to investigate if use of antidepressants is related to the risk of developing lower (WHO grade 2-3) and higher grade (WHO grade 4) glioma. A registry based case-control study was performed using 1283 glioma cases and 6400 age-, sex- and geographically matched controls, diagnosed in Sweden 2009-2013. Conditional logistic regression was used to analyze whether Selective Serotonin Reuptake Inhibitors (SSRIs) or non-SSRIs were associated with the risk of developing lower- or higher-grade glioma in the study population. Our results show that use of antidepressant medication was not associated with the risk of developing glioma. We also performed a meta-analysis in which the dataset from the present study was combined with results from two previous epidemiological studies to answer the same questions. The meta-analysis showed a modest risk reduction of developing glioma in relation to antidepressant treatment (OR 0.90 [95% CI 0.83-0.97]), when all glioma subgroups and all forms of antidepressant medications were combined. In conclusion, it remains possible that antidepressants may have common monoaminergic mechanism(s) that reduce the risk of developing glioma.

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  • 17.
    Munkvold, Bodil K. R.
    et al.
    Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
    Solheim, Ole
    Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway;Department of Neurosurgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
    Bartek, Jiri
    Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden;Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
    Corell, Alba
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden;Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
    de Dios, Eddie
    Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden;Department of Neuroscience, Uppsala University, Uppsala, Sweden.
    Gulati, Sasha
    Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway;Department of Neurosurgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
    Helseth, Eirik
    Department of Neurosurgery, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
    Holmgren, Klas
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper. Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden.
    Jensdottir, Margret
    Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
    Lundborg, Mina
    Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
    Mireles, Eduardo Erasmo Mendoza
    Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
    Mahesparan, Ruby
    Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway;Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.
    Tveiten, Øystein Vesterli
    Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway;Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.
    Milos, Peter
    Department of Neurosurgery, Linköping University Hospital, Sweden.
    Redebrandt, Henrietta Nittby
    Department of Clinical Sciences, Lund University, Lund, Sweden;Department of Neurosurgery, Skåne University Hospital, Lund, Sweden.
    Pedersen, Lars Kjelsberg
    Department of Neurosurgery, University Hospital of North Norway, Tromsø, Norway.
    Ramm-Pettersen, Jon
    Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper. Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden.
    Sjögren, Björn
    Department of Neurosurgery, Linköping University Hospital, Sweden.
    Sjåvik, Kristin
    Department of Neurosurgery, University Hospital of North Norway, Tromsø, Norway.
    Smits, Anja
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden;Department of Neuroscience, Uppsala University, Uppsala, Sweden.
    Tomasevic, Gregor
    Department of Neurosurgery, Skåne University Hospital, Lund, Sweden.
    Vecchio, Tomás Gómez
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden.
    Vik-Mo, Einar O.
    Department of Neurosurgery, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
    Zetterling, Maria
    Department of Neuroscience, Uppsala University, Uppsala, Sweden;Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden.
    Salvesen, Øyvind
    Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
    Jakola, Asgeir S.
    Variations in the Management of Diffuse Low-Grade Gliomas – a Scandinavian Multicenter Study2021Ingår i: Neuro-Oncology Practice, ISSN 2054-2577, E-ISSN 2054-2585, Vol. 8, nr 6, s. 706-717Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected “high-risk” patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohort study was to explore potential variations in diagnostic work-up and treatment between treating centers in two Scandinavian countries with similar public healthcare systems.

    Methods: Patients screened for inclusion underwent primary surgery of a histopathologically verified diffuse WHO grade II glioma in the time period 2012 through 2017. Clinical and radiological data were collected from medical records and locally conducted research projects, whereupon differences between countries and inter-hospital variations were explored.

    Results: A total of 642 patients were included (male:female ratio 1.4), and annual age-standardized incidence rates were 0.9 and 0.8 per 100 000 in Norway and Sweden, respectively. Considerable inter-hospital variations were observed in preoperative work-up, tumor diagnostics, surgical strategies, techniques for intraoperative guidance, as well as choice and timing of adjuvant therapy.

    Conclusions: Despite geographical population-based case selection, similar healthcare organization and existing guidelines, there were considerable variations in DLGG management. While some can be attributed to differences in clinical implementation of current scientific knowledge, some of the observed inter-hospital variations reflect controversies related to diagnostics and treatment. Quantification of these disparities renders possible identification of treatment patterns associated with better or worse outcomes and may thus represent a step toward more uniform evidence-based care.

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  • 18. Nilsson, Kent W
    et al.
    Alm, Per Olov
    Leppert, Jerzy
    Oreland, Lars
    Sjöberg, Rickard L
    Ohrvik, John
    [Interactions between genes and environment predict criminality, depression and alcohol dependence].2006Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, nr 39Artikel i tidskrift (Refereegranskat)
  • 19. Nilsson, Kent W.
    et al.
    Sjöberg, Rickard L.
    Damberg, Mattias
    Alm, Per Olof
    Öhrvik, John
    Leppert, Jerzy
    Lindström, Leif
    Oreland, Lars
    Role of the serotonin transporter gene and family function in adolescent alcohol consumption.2005Ingår i: Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, E-ISSN 1530-0277, Vol. 29, nr 4, s. 564-570Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: That the extent to which a particular individual will engage in problematic behaviors such as delinquency, violence, or drug abuse is determined by the way psychosocial, situational, and hereditary factors interact is widely accepted. However, only recently have researchers begun to investigate the interactions between specific genotypes and psychosocial factors in relation to behavior. The purpose of the present study was to investigate possible interactions between a polymorphism in the promoter region of the serotonin transporter (5-HTT) gene and family relations on adolescent alcohol consumption.

    METHODS: A cross-sectional study with a randomized sample from a total population of 16- and 19-year-old adolescents from a Swedish county was conducted. Eighty-one male and 119 female adolescents, who volunteered to participate after having answered a questionnaire, were randomly selected from quartiles of volunteers representing various degrees of psychosocial risk behavior.

    RESULTS: 5-HTT genotype (p=0.029) and family relations (p=0.022) predicted alcohol consumption independently as well as through an interaction with one another (p=0.05). The model explained 11% of the variance in alcohol consumption. In a binary logistic model, we found that adolescents with the LS variant of the 5-HTT gene and with family relations being "neutral" or "bad" had a 12- to 14-fold increased risk for high intoxication frequency.

    CONCLUSIONS: In sum, our results show that a functional polymorphism of the 5-HTT genotype, family relations, and interactions between these variables predict adolescent alcohol consumption in a randomized sample of adolescents.

  • 20. Nilsson, Kent W.
    et al.
    Sjöberg, Rickard L.
    Damberg, Mattias
    Leppert, Jerzy
    Öhrvik, John
    Alm, Per Olof
    Lindström, Leif
    Oreland, Lars
    Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity2006Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 59, nr 2, s. 121-127Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: A number of important sociological, psychological, and biological predictors of adolescent criminal behavior have been identified during the most recent decades. The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity.

    METHODS: A cross-sectional study with a randomized sample from the total population of 16- and 19-year-olds from the county of Västmanland, Sweden. Eighty-one male adolescents, who volunteered to participate, were randomly selected from groups representing different degrees of deviant risk behavior.

    RESULTS: The present study strongly supports the notion that carrying the 3-repeat allele of the MAO-A-gene promoter increases the risk of male adolescent criminal behavior, when interacting with psychosocial factors. No effects at all of the MAO-A genotype on adolescent criminal activity were found when MAO-A genotype was considered alone (i.e., without its psychosocial context). The explained variance of the bio-psychosocial model (controlling for MAO-A) in this study exceeded the psychosocial model by 12%.

    CONCLUSIONS: The findings support the notion that genotype and psychosocial factors interact to precipitate male adolescent criminal behavior.

  • 21. Nilsson, Kent W
    et al.
    Sjöberg, Rickard L
    Leppert, Jerzy
    Oreland, Lars
    Damberg, Mattias
    Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology.2009Ingår i: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 116, nr 3Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of this study was to investigate possible interactions between the gene coding for activating protein-2 beta (AP-2 beta) and psychosocial factors to predict depressive symptoms in adolescents. Two-hundred 16- and 19-year-old adolescents from the county of Västmanland, Sweden, were asked to complete a questionnaire, interviewed about psychosocial risk factors, and genotyped with regard to the transcription factor AP-2 beta intron 2 polymorphism. AP-2 beta genotype interacted significantly both with type of housing and parental separation to predict depressive symptoms. Individuals who were homozygous for the short AP-2 beta allele displayed higher depression scores when psychosocial adversity was taken into account. Amongst carriers of one or two copies of the long allele, there was no difference in depressive symptoms despite differences in psychosocial environments.

  • 22. Nilsson, Kent W
    et al.
    Sjöberg, Rickard L
    Wargelius, Hanna-Linn
    Leppert, Jerzy
    Lindström, Leif
    Oreland, Lars
    The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption.2007Ingår i: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 102, nr 3Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM: To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents.

    DESIGN, SETTING AND PARTICIPANTS: A cross-sectional study of a randomized sample of 66 male individuals from a total population of 16- and 19-year adolescents from a Swedish county. Boys, who volunteered to participate answering an alcohol-related problem/behaviour questionnaire, were investigated with regard to interactions between such problems, family function, maltreatment and MAO-A genotype.

    MEASUREMENTS: MAO-A genotype, family relations history, history of being maltreated or abused and alcohol-related problem behaviour.

    FINDINGS: Boys with the short (three-repeat) variant of the MAO-A gene, who had been maltreated/abused or came from families with poor relations, showed significantly higher scores of alcohol-related problems. We also found that maltreatment/abuse independently showed the strongest relation to alcohol-related problems among boys in our model.

    CONCLUSIONS: The results suggest that both maltreatment and MAO-A genotype may be useful for the understanding of male adolescent alcohol-related problem behaviour.

  • 23.
    Nilsson, Kent W.
    et al.
    Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89, Västerås, Sweden.
    Sonnby, Karin
    Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89, Västerås, Sweden.
    Nordquist, Niklas
    Department of Neuroscience, Uppsala University, POB 593, 751 24, Uppsala, Sweden.
    Comasco, Erika
    Department of Neuroscience, Uppsala University, POB 593, 751 24, Uppsala, Sweden.
    Leppert, Jerzy
    Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89, Västerås, Sweden.
    Oreland, Lars
    Department of Neuroscience, Uppsala University, POB 593, 751 24, Uppsala, Sweden.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Transcription Factor Activating Protein-2 beta (TFAP-2 beta) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples2014Ingår i: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 23, nr 4, s. 207-217Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Transcription Factor Activating Protein-2 beta (TFAP-2 beta) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2 beta. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP-2 beta gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8 % of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP-2 beta intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP-2 beta intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.

  • 24. Nilsson, Kent W
    et al.
    Wargelius, Hanna-Linn
    Sjöberg, Rickard L
    Leppert, Jerzy
    Oreland, Lars
    The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour.2008Ingår i: Drug And Alcohol Dependence, ISSN 0376-8716, E-ISSN 1879-0046, Vol. 93, nr 1-2Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Antisocial behaviour has been associated with polymorphic variants in candidate genes and recently also gene-environmental interaction models have been presented. It has been suggested that antisocial behaviour, associated with alcohol consumption in males, is related to a variation in the monoamine oxidase A gene (MAO-A) promoter. Furthermore, platelet MAO-B activity has in several studies been reported to be low in male alcoholics, while this has not been the case with regard to female alcoholics. Aims of the present study were to: (1) investigate possible interactions between the MAO-A polymorphism, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among female adolescents; (2) to investigate if platelet MAO-B enzyme activity interacted with environment to predict female alcohol-related problems.

    METHODS: A random sample of 114 female individuals from a total population of 16- and 19-year adolescents from a Swedish county, who volunteered to participate in the study, were interviewed, filled in a questionnaire and a blood sample was drawn.

    RESULTS: In contrast to what has been reported in males, presence of the long (4-repeat) variant of the MAO-A gene in females interacted significantly with an unfavourable environment (poor family relations or maltreatment/abuse/sexual abuse) to increase the risk for high scores of alcohol-related problems. Furthermore, females with low platelet MAO-B activity showed an increased risk of alcohol-related problem behaviour in an unfavourable environment.

    CONCLUSIONS: Poor psychosocial environment interacts with the high activity MAO-A genotype and low platelet MAO-B enzyme activity to increase vulnerability for female adolescent alcohol-related problem behaviour.

  • 25.
    Philipsson, Johanna
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Yelnik, Jerome
    Blomstedt, Patric
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Acute severe depression induced by stimulation of the right globus pallidus internus2017Ingår i: Neurocase, ISSN 1355-4794, E-ISSN 1465-3656, Vol. 23, nr 1, s. 84-87Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Depressive symptoms may occur after Deep Brain Stimulation (DBS) in the subthalamic nucleus. This is often explained by reduced pharmacological treatment after surgery, and not as a direct effect of DBS. Pallidal DBS seems not to be associated with such side effects and have not, to our knowledge, previously been reported. We present a patient with acute depressive symptoms induced by pallidal DBS. We believe this case strengthen the hypothesis that the basal ganglia and structures involved in the functional connectome of these nucleuses play a role not only in regulation of movement but also in regulation of mood.

  • 26. Schwandt, Melanie L
    et al.
    Lindell, Stephen G
    Sjöberg, Rickard L
    Chisholm, Kelli L
    Higley, J Dee
    Suomi, Stephen J
    Heilig, Markus
    Barr, Christina S
    Gene-environment interactions and response to social intrusion in male and female rhesus macaques.2010Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 67, nr 4Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Genetic factors interact with environmental stressors to moderate risk for human psychopathology, but sex may also be an important mediating factor. Different strategies for coping with environmental stressors have evolved in males and females, and these differences may underlie the differential prevalence of certain types of psychopathology in the two sexes. In this study, we investigated the possibility of sex-specific gene-environment interactions in a nonhuman primate model of response to social threat.

    METHODS: Rhesus macaques (77 males and 106 females) were exposed to an unfamiliar conspecific. Using factor analysis, we identified three behavioral factors characterizing the response to social threat. Monkeys were genotyped for the serotonin transporter-linked polymorphism (5-HTTLPR), and the effects of genotype, early life stress, and sex on behavioral responses were evaluated.

    RESULTS: Factor analysis produced five factors: High-Risk Aggression, Impulsivity/Novelty-Seeking, Gregariousness/Boldness, Harm Avoidance, and Redirected Aggression. Overall, males displayed higher levels of High-Risk Aggression and Gregariousness/Boldness than females. Levels of High-Risk Aggression in males carrying the s allele were significantly higher if they were also exposed to early adversity in the form of peer rearing.

    CONCLUSIONS: Our findings support those from studies in humans suggesting that males are more vulnerable to externalizing or aggression-related disorders. The results highlight the importance of interactions that exist among behavior, genes, and the environment and suggest that sex differences in vulnerability to psychopathology may be grounded in our evolutionary history.

  • 27. Sjöberg, R L
    Childhood abuse and later revictimisation of women.2001Ingår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 358, nr 9297Artikel i tidskrift (Refereegranskat)
  • 28. Sjöberg, R L
    [Childhood amnesia and emotional trauma. Easiest to prompt the smallest children to provide erroneous details concerning abuse].2001Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 98, nr 26-27Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    A basic understanding of children's memories for emotional trauma is of importance for physicians and other health care professionals. The aim of this paper is to describe recent research and discuss important dilemmas within this field. The ability of infants and toddlers to verbally describe autobiographical memories is for several reasons limited. Very early experiences of e.g. intense pain can leave traces in the nervous system but of a kind which is not specific enough to allow retrospective conclusions about the nature of these experiences. Research during the past decades has relatively consistently demonstrated that pre-school children are more vulnerable to suggestion including abuse-related suggestions than are older children and adults. However, many children who have been subject to sexual abuse seem to maintain a lifelong silence about their experiences. The use of autobiographical testimony from young children is more complex and risky than many professionals believed about a decade ago. Establishing the knowledge derived from recent years' research in this area as a basis for clinical practice is one of the most important tasks for the future.

  • 29. Sjöberg, R L
    False allegations of satanic abuse: case studies from the witch panic in Rättvik 1670-71.1997Ingår i: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 6, nr 4Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The creation of false memories, psychiatric symptoms and false allegations of satanic child abuse during an outbreak of witch hysteria in Sweden in the seventeenth century are described and related to contemporary issues in child testimonies. Case studies of 28 children and 14 adults are presented. The mechanisms underlying the spread of these allegations, as well as the reactions and influence of the adult world on the children's testimonies, are discussed.

  • 30. Sjöberg, R L
    The catechism effect: child testimonies during a 17th-century witch panic as related to educational achievement.2000Ingår i: Memory, ISSN 0965-8211, E-ISSN 1464-0686, Vol. 8, nr 2Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Testimonies from 488 children given to the priests of the parish of Rättvik during a preliminary investigation of a Swedish witch panic in 1670-71 are examined in relation to records from parish catechetical meetings held in 1671. The result implies that children who knew and understood at least parts of Luther's catechism were less liable to have falsely alleged that they had been kidnapped by female satanists during the witch panic of the previous year. It is suggested that these effects were caused by differences in cognitive, social, and emotional resources among these children as compared to those who were unable to learn and understand any parts of Luther's catechism.

  • 31. Sjöberg, R L
    et al.
    Lindblad, F
    Delayed disclosure and disrupted communication during forensic investigation of child sexual abuse: a study of 47 corroborated cases.2002Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 91, nr 12Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    AIM: To study factors of relevance for the understanding of disclosure of child sexual abuse.

    METHODS: Cases from a Swedish district court involving 47 children in which allegations of child sexual abuse had been corroborated by a confession from the defendant were studied.

    RESULTS: Delayed disclosure was related to a close relationship with the perpetrator and young age at the first experience of abuse. Disrupted communication during the police interview was related to less violent abuse.

    CONCLUSION: The findings highlight the importance of social factors in children's disclosure of sexual abuse.

  • 32. Sjöberg, R L
    et al.
    Lindholm, T
    Decision-making and euthanasia.2003Ingår i: British Journal of Psychiatry, ISSN 0007-1250, E-ISSN 1472-1465, Vol. 182Artikel i tidskrift (Refereegranskat)
  • 33.
    Sjöberg, Richard L
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
    Blomstedt, Patric
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
    The psychological neuroscience of depression: implications for understanding effects of deep brain stimulation2011Ingår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 52, nr 5, s. 411-419Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this article it is suggested that current psychological theories of depression presuppose that this condition will develop as a result of a vicious circle involving negatively biased communication between systems of emotional stress-/alarm-signaling, executive functions and mood regulation. These systems may from a neuroanatomical point of view be located in the limbic system, the orbitofrontal and lateral prefrontal cortex and the hypothalamus-pituitary-adrenal (HPA-) axis respectively. The theoretical and practical implications of this model for the understanding of pharmacological treatments of depression are briefly discussed and this theory is related to the catecholamine hypothesis of depression. The model is furthermore discussed in relation to deep brain stimulation (DBS) of treatment resistant major depression. Similarities and differences between this perspective and the one advocated by the "homeostatic theory" of depression are discussed. It is concluded that a topographical psychological theory may offer a useful heuristic in thinking about depression and that it offers several testable predictions about treatments of the disorder.

  • 34.
    Sjöberg, Richard L
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Lidman, Elin
    Häggström, Björn
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Hariz, Marwan I
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Linder, Jan
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Fredricks, Anna
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Blomstedt, Patric
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Verbal fluency in patients receiving bilateral versus left-sided deep brain stimulation of the subthalamic nucleus for Parkinson's disease2012Ingår i: Journal of the International Neuropsychological Society, ISSN 1355-6177, E-ISSN 1469-7661, Vol. 18, nr 3, s. 606-611Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation. (JINS, 2012, 18, 606-611)

  • 35. Sjöberg, Rickard L
    [A critical question: Therapeutic effect or regression towards the mean?].2006Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, nr 26-27Artikel i tidskrift (Refereegranskat)
  • 36. Sjöberg, Rickard L
    [A forgotten theory about the cause of hydrocephalus].2009Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 106, nr 42Artikel i tidskrift (Refereegranskat)
  • 37.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Brain stimulation and elicited memories2023Ingår i: Acta Neurochirurgica, ISSN 0001-6268, E-ISSN 0942-0940, Vol. 165, nr 10, s. 2737-2745Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Background: Since the late 1930s, electric brain stimulation (EBS) in awake patients has been known to occasionally elicit patient descriptions of a form of memory flashbacks, known as experiential phenomena. One understanding of these sensations are as caused by an augmentation of the capacity for memory retrieval. However, an alternative hypothesis holds that memory flashbacks during EBS are "synthetic constructions" in the form of mental events, falsely interpreted as memories.

    Methods: A critical narrative review is used to discuss the false memory hypothesis in relation to the current empirical literature and source attribution theory.

    Results: EBS as well as situational demands in the form of interaction between patient and neurosurgeon may both lead to the creation of mental events and influence their interpretation in a way that may create false memories. The false memory hypothesis provides a potential explanation for several apparent inconsistencies in the current literature such as (a) the fragmented nature of experiential reports, (b) the ability of EBS to induce memory retrieval errors in controlled studies, (c) that Penfield's elicitations of experiential phenomena are so rarely replicated in the modern era, and (d) the limited utility of techniques that elicit experiential phenomena in the treatment of memory disorders.

    Conclusions: The hypothesis that experiential phenomena may largely be "synthetic constructions" deserves serious consideration by neurosurgeons.

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  • 38.
    Sjöberg, Rickard L
    Norrlands universitetssjukhus.
    Charcots fotnot: svår för vetenskapen att förtränga2015Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 112, nr 18-19Artikel i tidskrift (Övrigt vetenskapligt)
  • 39. Sjöberg, Rickard L.
    Child testimonies during an outbreak of witch hysteria: Sweden 1670-16711995Ingår i: Journal of Child Psychology and Psychiatry, ISSN 0021-9630, E-ISSN 1469-7610, Vol. 36, nr 6, s. 1039-1051Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Eight hundred and nine testimonies given by children between the ages of 1 and 16 to the priests of the parish of Rättvik, and to the Royal commission of inquiry, during an outbreak of witch hysteria in 1670-71 are examined. The result implies that the capacity to separate reality from fantasy as well as the tendency to give stereotyped testimonies are related to age, social influence from other children and sex. The results also suggest that the testimonies were influenced by the person investigating the child.

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  • 40.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Den vetenskapliga bakgrunden: [The scientific background]2022Ingår i: Barnförhör: att få vetenskap och juridik att fungera i praktiken / [ed] Anneli Larsson; Rickard L. Sjöberg, Lund: Studentlitteratur AB, 2022, s. 19-33Kapitel i bok, del av antologi (Refereegranskat)
  • 41. Sjöberg, Rickard L
    False claims of victimization: a historical illustration of a contemporary problem.2002Ingår i: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 56, nr 2Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this article, a false claim of victimization made by a man in his late 20s during a 17th-century outbreak of mass allegations of Satanic abuse is described and discussed in relation to contemporary issues with relevance to psychiatry and applied mental health.

  • 42.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap.
    Five myths about witch-hunts2019Ingår i: Washington Post, s. B3-B3Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 43.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Five psychological mechanisms that might bias learning from neurosurgical complications: case discussions and a narrative review2022Ingår i: British Journal of Neurosurgery, ISSN 0268-8697, E-ISSN 1360-046X, Vol. 36, nr 3, s. 323-328Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Purpose: The ability of neurosurgeons to analyze and reflect on their complications in a constructive way is important both for professional development and for patient safety. The purpose of the present paper is to highlight some psychological factors that might impair or bias the ability of the neurosurgeon to do this successfully.

    Methods: Five fictitious cases, loosely inspired by real events and situations, are used as a basis for a discussion of some of the most important potential sources of psychological bias in the context of understanding neurosurgical complications.

    Results: The issues of a) self-serving bias and the actor-observer effect; b) heuristics and biases in interpreting probabilistic events; c) emotional avoidance and denial; d) limitations of attention (dual systems theory) and e) errors of memory, are discussed.

    Conclusion: There are a number of psychological factors, that are well known to science that may be ubiquitous sources of influence on the ability of neurosurgeons to grow by reflection on their own complications. Exactly how these factors can and should be efficiently adressed by the individual neurosurgeon and/or the organisation and team in which the neurosurgeon works may vary according to type of bias, context and circumstances. However, being aware of these issues and addressing them on an individual and organizational level remains important to the quality of our craft.

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  • 44.
    Sjöberg, Rickard L
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Free will and neurosurgical resections of the supplementary motor area: a critical review2021Ingår i: Acta Neurochirurgica, ISSN 0001-6268, E-ISSN 0942-0940, Vol. 163, nr 5, s. 1229-1237Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Research suggests that unconscious activity in the supplementary motor area (SMA) precedes not only certain simple motor actions but also the point at which we become aware of our intention to perform such actions. The extent to which these findings have implications for our understanding of the concepts of free will and personal responsibility has been subject of intense debate during the latest four decades.

    Methods: This research is discussed in relation to effects of neurosurgical removal of the SMA in a narrative review.

    Results: Removal of the SMA typically causes a transient inability to perform non-stimulus-driven, voluntary actions. This condition, known as the SMA syndrome, does not appear to be associated with a loss of sense of volition but with a profound disruption of executive function/cognitive control.

    Conclusions: The role of the SMA may be to serve as a gateway between the corticospinal tract and systems for executive function. Such systems are typically seen as tools for conscious decisions. What is known about effects of SMA resections would thus seem to suggest a view that is compatible with concepts of personal responsibility. However, the philosophical question whether free will exists cannot be definitely resolved on the basis of these observations.

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  • 45. Sjöberg, Rickard L
    [Genes and individual behavioral variations. The genome as a memory for experiences of the individual and the family].2008Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 105, nr 23Artikel i tidskrift (Refereegranskat)
  • 46.
    Sjöberg, Rickard L
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Hjärnan och jaget: Operationsberättelser från platsen mellan kropp och själ2024Bok (Övrig (populärvetenskap, debatt, mm))
  • 47. Sjöberg, Rickard L
    [It is easy to defend conversation as therapeutic method if the method is scientifically evaluated].2003Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 100, nr 41Artikel i tidskrift (Refereegranskat)
  • 48.
    Sjöberg, Rickard L.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Om minnesprocessen: [The process of remembering]2022Ingår i: Barnförhör: att få vetenskap och juridik att fungera i praktiken / [ed] Anneli S. Larsson; Rickard L. Sjöberg, Lund: Studentlitteratur AB, 2022, s. 35-46Kapitel i bok, del av antologi (Refereegranskat)
  • 49.
    Sjöberg, Rickard L
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
    Påverkar den supplementära motorarean den fria viljan?2022Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, nr 15-16Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [sv]

    Inom neurovetenskapen dök det för cirka 40 år sedan upp en teori om att det område som kallas supplementära motorarean skulle fatta besluten åt oss – och att den fria viljan på så sätt egentligen inte skulle existera. Men riktigt så enkelt är det inte, visar nya undersökningar. 

  • 50. Sjöberg, Rickard L
    [Satanic ritualistic murders and child abuse--evidence-basing versus ideology].2005Ingår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 102, nr 40Artikel i tidskrift (Refereegranskat)
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