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  • 1. Brechter, M
    et al.
    Nilson, H
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Oxidized titanium implants in reconstructive jaw surgery.2005Ingår i: Clinical Implant Dentistry and Related Research, Vol. 7, nr Suppl 1, s. 83-7Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Rehabilitation with implant-supported bridges in patients with insufficient bone volumes may require bone reconstructive procedures in conjunction with or prior to implant placement. Clinical follow-up studies using turned titanium and bone grafts have demonstrated higher failure rates than when used in nongrafted patients. Improved bone integration has been demonstrated for oxidized titanium implants; however, their clinical performance in bone reconstruction situations is not known. PURPOSE: This study was performed to analyze the survival and stability of oxidized titanium implants placed in patients subjected to reconstructive jaw surgery at one clinic. MATERIALS AND METHODS: Two hundred oxidized titanium implants (Mk III, TiUnite, Nobel Biocare AB, Göteborg, Sweden) were placed in 47 patients in conjunction with or secondary to six different reconstructive procedures owing to insufficient bone volume. In all six groups, implant stability was assessed by resonance frequency analysis and manually checked for rotation stability at implant insertion, at the time of abutment connection, and after a minimum of 12 months of loading of the prosthetic construction. Periapical radiographs were taken after a minimum of 12 months of loading (mean 21 months) for evaluation of the marginal bone levels. The mean clinical follow-up period was 30 months. RESULTS: Of the 200 implants, 199 were considered osseointegrated at the time of abutment surgery. At the 12-month postloading follow-up, another two implants were considered not stable. Three implants (1.5%) were ranked as unsuccessful. CONCLUSION: Clinical experience with 200 consecutive oxidized implants in various reconstruction situations shows a successful outcome, with only three failures (1.5%) during a mean follow-up period of 30 months.

  • 2. Clavero, J
    et al.
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Ramus or chin grafts for maxillary sinus inlay and local onlay augmentation: comparison of donor site morbidity and complications.2003Ingår i: Clinical Implant Dentistry and Related Research, Vol. 5, nr 3, s. 154-60Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: The placement of endosseous implants in edentulous areas is frequently limited by inadequate bone volume of the residual ridge. Local bone grafts from the mandible are a convenient source of autogenous bone for alveolar reconstruction prior to implant placement. PURPOSE: The aim of the present study was to document and compare the morbidity and the frequency of complications occurring at two intraoral donor sites: the mandibular symphysis and the mandibular ramus. MATERIAL AND METHODS: This study reviewed 53 consecutively treated patients: 29 with autogenous bone grafts from the mandibular symphysis and 24 with mandibular ramus bone grafts. Each patient received a questionnaire 18 months after surgery regarding problems that may have occurred during the postoperative period. RESULTS: In the patients in whom bone was harvested from the mandibular ramus, there were fewer postoperative symptoms immediately after the operation than with mandibular symphysis harvesting. Twenty-two of the 29 patients with symphysis grafts experienced decreased sensitivity in the skin innervated by the mental nerve 1 month after the operation. Five of the 24 patients with ramus grafts experienced decreased sensitivity in the vestibular mucosa corresponding to the innervation of the buccal nerve. Eighteen months after the surgery, 15 of the 29 patients in the symphysis group still had some decreased sensitivity and presented with permanent altered sensation. Only one of the patients grafted from the mandibular ramus presented with permanent altered sensation in the posterior vestibular area. No major complication occurred in the donor sites in any of the 53 patients. CONCLUSION: The results of this study favored the use of the ascending mandibular ramus as an intraoral donor site for bone grafting.

  • 3.
    Cricchio, Giovanni
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Imburgia, Mario
    Sennerby, Lars
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Immediate Loading of Implants Placed Simultaneously with Sinus Membrane Elevation in the Posterior Atrophic Maxilla: a Two-Year Follow-Up Study on 10 Patients2014Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 16, nr 4, s. 609-617Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Clinical studies on immediate loading of implants in the posterior atrophic maxilla are rare.

    PURPOSE: The study aims to evaluate immediate loading of implants placed with sinus membrane elevation without additional grafting material for bone augmentation of the maxillary sinus floor.

    MATERIALS AND METHODS: The study group comprised of 10 patients in whom a total of 10 maxillary sinus floor augmentations were performed. A total of 21 dental implants (1 to 4) were inserted through the residual bone to protrude into the maxillary sinus under the elevated sinus membrane. The implant site was underprepared to improve primary stability. All the implants were inserted with a torque insertion no less than 20 Ncm. Implants were loaded immediately after surgery with a screw-retained temporary acrylic restoration. Intraoral X-rays were taken at implant insertion, after 6 months loading, and after 1st and 2nd year of loading. Resonance frequency analysis (RFA) was performed at the time of initial placement and after 6 months of functional loading. RESULTS: RFA after implant insertion gave an implant stability quotient (ISQ) level with a range from 62 to 72. All implants remained clinically stable during the follow-up period of 2 years. Radiography demonstrated on average 5.7 ± 3.4 mm of intrasinus new bone formation after 6 months of implant loading. RFA measurements showed ISQ mean values of 67 (range: 62-72) and 68 (range: 62-71) at placement and after 6 months of loading, respectively.

    CONCLUSION: Within the limits of this case series report, it is concluded that maxillary sinus membrane elevation with simultaneous placement and immediate loading of implants without the use of any additional grafting material shows predictable results after 2 years of functional loading. Moreover, evidence of intrasinus bone formation around the implants was found in all patients. Further studies are needed to study the influence of immediate loading on the mineralization of bone forming at dental implant sites.

  • 4.
    Cricchio, Giovanni
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Donor site morbidity in two different approaches to anterior iliac crest bone harvesting2003Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 5, nr 3, s. 161-169Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Bone grafting is a surgical technique for the reconstruction of the atrophic edentulous maxilla prior to treatment with endosseous implants. The anterior iliac crest is a commonly used donor site.

    PURPOSE: The aim of this study was to evaluate the donor site morbidity and complications when harvesting corticocancellous bone from the medial table of the anterior iliac crest and compare this with results when bone was harvested from the lateral and superior table of the anterior iliac crest. In addition, the outcome of the oral rehabilitation was evaluated by means of a quality-of-life questionnaire.

    MATERIAL AND METHODS: The study was composed of 70 consecutively treated patients with a mean age of 56 years. The patients were retrospectively evaluated with regard to postoperative donor site morbidity and complications at the donor site.

    RESULTS: For the donor site morbidity, 74% of the patients were free of pain within 3 weeks, whereas 26% of the patients had a prolonged period of pain lasting from a few weeks to several months. For 11% of the patients, there was still some pain or discomfort 2 years after the grafting surgery. For gait disturbance the figures were similar: 79% had no problems after 3 weeks. For the eight patients who still had some pain after 2 years, which was considered permanent, three also had gait disturbance. There was a total of three major complications (4%), one iliac wing fracture and two neurologic injuries.

    CONCLUSION: When harvesting a large amount of unicortical corticocancellous bone blocks from the the superolateral site of the iliac crest with a "peel off" technique, morbidity and complication rates do not differ significantly compared with those of the traditional anterior medial approach. Oral rehabilitation with maxillary reconstruction with bone grafts from the iliac crest and endosseous implants significantly improved oral function, facial appearance, and recreation/social activities and resulted in an overall improvement in quality of life in formerly edentulous patients.

  • 5.
    Cricchio, Giovanni
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Palma, Vinicious Canavarros
    Faria, Paolo E P
    de Olivera, José Americo
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Salata, Luiz A
    Histological outcomes on the development of new space-making devices for maxillary sinus floor augmentation2011Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 13, nr 3, s. 224-230Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Previous studies have pointed out that the mere elevation of the maxillary sinus membrane promotes bone formation without the use of augmentation materials.

    Purpose: This experimental study aimed at evaluating if the two-stage procedure for sinus floor augmentation could benefit from the use of a space-making device in order to increase the bone volume to enable later implant installation with good primary stability.

    Materials and Methods: Six male tufted capuchin primates (Cebus apella) were subjected to extraction of the three premolars and the first molar on both sides of the maxilla to create an edentulous area. The sinuses were opened using the lateral bone-wall window technique, and the membrane was elevated. One resorbable space-making device was inserted in each maxillary sinus, and the bone window was returned in place. The animals were euthanatized after 6 months, and biopsy blocks containing the whole maxillary sinus and surrounding soft tissues were prepared for ground sections.

    Results: The histological examination of the specimens showed bone formation in contact with both the schneiderian membrane and the device in most cases even when the device was displaced. The process of bone formation indicates that this technique is potentially useful for two-stage sinus floor augmentation. The lack of stabilization of the device within the sinus demands further improvement of space-makers for predictable bone augmentation.

    Conclusions: It is concluded that (1) the device used in this study did not trigger any important inflammatory reaction; (2) when the sinus membrane was elevated, bone formation was a constant finding; and (3) an ideal space-making device should be stable and elevate the membrane to ensure a maintained connection between the membrane and the secluded space.

  • 6.
    Cricchio, Giovanni
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Palma, Vinícius Canavarros
    Faria, Paulo E P
    de Oliveira, José Américo
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Salata, Luiz A
    Histological findings following the use of a space-making device for bone reformation and implant integration in the maxillary sinus of primates2009Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 11, nr suppl 1, s. e14-e22Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Previous studies have shown that membrane elevation results in predictable bone formation in the maxillary sinus provided that implants can be placed as tent poles. In situations with an extremely thin residual crest which impairs implant placement, it is possible that a space-making device can be used under the sinus membrane to promote bone formation prior to placement of implants.

    PURPOSE: The present study was conducted to test the hypothesis that the use of a space-making device for elevation of the sinus membrane will result in predictable bone formation at the maxillary sinus floor to allow placement of dental implants.

    MATERIALS AND METHODS: Eight tufted capuchin primates underwent bilateral sinus membrane elevation surgery, and a bioresorbable space-making device, about 6 mm wide and 6 mm in height, was placed below the elevated membrane on the sinus floor. An oxidized implant (Nobel Biocare AB, Gothenburg, Sweden) was installed in the residual bone protruding into the created space at one side while the other side was left without an implant. Four animals were sacrificed after 6 months of healing. The remaining four animals received a second implant in the side with a space-making device only and followed for another 3 months before sacrifice. Implant stability was assessed through resonance frequency analysis (RFA) using the Osstell (Osstell AB, Gothenburg, Sweden) at installation, 6 months and 9 months after the first surgery. The bone-implant contact (BIC) and bone area inside the threads (BA) were histometrically evaluated in ground sections.

    RESULTS: Histologically there were only minor or no signs of bone formation in the sites with a space-making device only. Sites with simultaneous implant placement showed bone formation along the implant surface. Sites with delayed implant placement showed minor or no bone formation and/or formation of a dense fibrous tissue along the apical part of the implant surface. In the latter group the apical part of the implant was not covered with the membrane but protruded into the sinus cavity.

    CONCLUSIONS: The use of a space-making device, with the design used in the present study, does not result in bone formation at the sinus floor. However, membrane elevation and simultaneous placement of the device and an implant does result in bone formation at the implant surface while sites with implants placed 6 months after membrane elevation show only small amounts of bone formation. It is suggested that lack of stabilization of the device and/or a too extensive elevation of the membrane may explain the results.

  • 7.
    Cricchio, Giovanni
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Department of Biomaterials, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden .
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sinus bone formation and implant survival after sinus membrane elevation and implant placement: a 1- to 6-year follow-up study2011Ingår i: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 22, nr 10, s. 1200-1212Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives: To investigate the long-term clinical and radiographic results of the maxillary sinus membrane elevation technique where implants were inserted in a void space created by the elevation of the sinus membrane without adding any graft material.

    Materials and methods: A total of 84 patients were subjected to 96 membrane elevation procedures and simultaneous placement of 239 implants. Changes of intra-sinus and marginal bone height in relation to the implants were measured in intraoral radiographs taken at insertion, after 6 months of healing, after 6 months of loading and then annually. Computerized tomography was performed pre-surgically and 6 months post-surgically. Resonance Frequency Analyses measurements were performed at the time of implants placement, at abutment connection and after 6 months of loading. The implant follow-up period ranged from a minimum of one to a maximum of 6 years after implants loading.

    Results: All implants were stable after 6 months of healing. A total of three implants were lost during the follow-up period giving a survival rate of 98.7%. Radiography demonstrated on average 5.3±2.1 mm of intra-sinus new bone formation after 6 months of healing. RFA measurements showed adequate primary stability (implant stability quotient 67.4±6.1) and small changes over time.

    Conclusion: Maxillary sinus membrane elevation and simultaneous placement of implants without the use of bone grafts or bone substitutes result in predictable bone formation with a high implant survival rate of 98.7% during a follow-up period of up to 6 years. The intra-sinus bone formation remained stable in the long-term follow-up. It is suggested that the secluded compartment allowed for bone formation according to the principle of guided tissue regeneration. The high implant survival rate of 98.7% indicated that the implants sufficiently supported the fixed bridges throughout the study period. This technique reduces the risks for morbidity related to harvesting of bone grafts and eliminates the costs of grafting materials.

  • 8.
    Cricchio, Giovanni
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Sennerby, Lars
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Sinus floor augmentation without bone grafting2019Ingår i: The sinus bone graft / [ed] Ole T. Jensen, Batavia: Quintessence Publishing , 2019, 3, s. 66-72Kapitel i bok, del av antologi (Refereegranskat)
    Abstract [en]

    As research proceeds on treatment of the resorbed posterior maxilla, new techniques and innovations continue to be adopted to solve this clinical problem. While the previous edition of this book provided detailed information on the types of grafting materials and procedures available at the time, this completely revised version looks to the future with new strategies for treatment, some of which avoid grafting altogether. This book not only reviews the time-tested lateral window approach for sinus elevation and grafting but also describes a variety of techniques to approach the sinus transcrestally with or without grafting material. One section of the book is devoted entirely to the different types of implants and implant placement techniques available, many of which are designed specifically to avoid sinus elevation. In addition to clinical case studies and descriptions of how to perform specific surgical procedures, this book includes discussions on the science of bone formation and how continued research brings us closer every day to the ultimate goal of using tissue engineering to completely regenerate new teeth.

  • 9. de Oliveira Neto, Patricio José
    et al.
    Cricchio, Giovanni
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Hawthorne, Ana Carolina
    Okamoto, Roberta
    Sennerby, Lars
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Salata, Luiz Antonio
    Tomographic, histological, and immunohistochemical evidences on the use of N-butyl-2-cyanoacrilate for onlay graft fixation in rabbits2012Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 14, nr 6, s. 861-871Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The bone tissue responses to Cyanoacrylate have been described in the literature, but none used N-butyl-2-cyanoacrilate (NB-Cn) for bone graft fixation.

    Purpose: The aims of the study were: (a) to analyze the bone grafts volume maintenance fixed either with NB-Cn or titanium screw; (b) to assess the incorporation of onlay grafts on perforated recipient bed; and (c) the differences of expression level of tartrate-resistant acid phosphatase (TRAP) protein involved in bone resorption.

    Materials and Methods: Eighteen New Zealand White rabbits were submitted to calvaria onlay grafting on both sides of the mandible. On one side, the graft was fixed with NB-Cn, while on the other hand the bone graft was secured with an osteosynthesis screw. The computed tomography (CT) was performed just after surgery and at animals sacrifice, after 1 (n = 9) and 6 weeks (n = 9), in order to estimate the bone grafts volume along the experiments. Histological sections of the grafted areas were prepared to evaluate the healing of bone grafts and to assess the expression of TRAP protein.

    Results: The CT scan showed better volume maintenance of bone grafts fixed with NB-Cn (p ≤ 0.05) compared with those fixed with screws, in both experimental times (analysis of variance). The immunohistochemical evaluation showed that the TRAP expression in a 6-week period was significantly higher compared with the 1-week period, without showing significant difference between the groups (Wilcoxon and Mann-Whitney). Histological analysis revealed that the NB-Cn caused periosteum damage, but provided bone graft stabilization and incorporation similar to the control group.

    Conclusion: The perforation provided by screw insertion into the graft during fixation may have triggered early revascularization and remodeling to render increased volume loss compared with the experimental group. These results indicate that the NB-Cn possesses equivalent properties to titanium screw to be used as bone fixation material in osteosynthesis.

  • 10. Hallman, M
    et al.
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Sennerby, L
    Histologic analysis of clinical biopsies taken 6 months and 3 years after maxillary sinus floor augmentation with 80% bovine hydroxyapatite and 20% autogenous bone mixed with fibrin glue.2001Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 3, nr 2, s. 87-96Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Bovine hydroxyapatite (Bio-Oss, Geistlich Pharmaceutical, Wollhausen, Switzerland) has been suggested to be used in maxillary sinus floor augmentation procedures prior to or in conjunction with implant placement. However, the long-term histologic fate of this material is not well understood. PURPOSE: The aim with this study was to histologically evaluate the tissue response in patients to a mixture of bovine hydroxyapatite (BH), autogenous bone, and fibrin glue 6 months and 3 years after a maxillary sinus floor augmentation procedure. MATERIALS AND METHOD: Biopsies were taken from a group of 20 consecutive patients 6 months (n = 16) and 3 years (n = 12) after maxillary sinus floor augmentation with a mixture of BH (80%), autogenous bone (20%), and fibrin glue and prepared for histologic analysis. RESULTS: Light microscopy and morphometry from biopsies taken after 6 months showed various amounts of mineralized bone tissue. The specimen area was occupied by 54.1 +/- 12.6% nonmineralized tissue, followed by 21.2 +/- 24.5% lamellar bone, 14.5 +/- 10.3% BH particles, and 10.2 +/- 13.4% woven bone. The nonmineralized tissue seen in bone-forming areas consisted of a loose connective tissue, rich with vessels and cells. There were no signs of resorption of the BH particles. The lamellar bone appeared to have originated from the recipient site and was seldom in contact with the BH particles. After 3 years, the nonmineralized tissue area had decreased to 36.0 +/- 19.0% (p < .05) and consisted mainly of bone marrow tissue. The surface area of lamellar bone had increased to 50.7 +/- 22.8% (p < .05), and there was almost no immature bone. The mean specimen area occupied by BH particles, was 12.4 +/- 8.7% and had not changed from 6 months (not significant). Moreover, the sizes of the particles were similar after 6 months and 3 years. The degree of BH particle-bone contact had increased from 28.8% +/- 19.9% after 6 months to 54.5 +/- 28.8% after 3 years (p < .05). CONCLUSION: Histology of specimens from maxillary sinuses augmented with 80% BH particles, 20% autogenous bone, and fibrin glue showed a positive bone tissue response after 6 months and 3 years after augmentation of the maxillary sinus floor prior to implant placement in a group fo 20 patients. The bone surrounding and in contact with the BH particles after 6 months was mainly immature woven bone, which with time was replaced by mature lamellar bone filling the interparticle space as observed in the 3-year specimens. Moreover, bone-integrated BH particles seem to be resistant to resorption. The results indicate that the procedure may be considered when only small amounts of intraoral autogenous bone graft are available.

  • 11. Hallman, M
    et al.
    Sennerby, L
    Zetterqvist, L
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    A 3-year prospective follow-up study of implant-supported fixed prostheses in patients subjected to maxillary sinus floor augmentation with a 80:20 mixture of deproteinized bovine bone and autogenous bone Clinical, radiographic and resonance frequency analysis.2005Ingår i: International Journal of Oral and Maxillofacial Surgery, Vol. 34, nr 3, s. 273-80Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The purpose of this prospective clinical study was to evaluate the 3-year outcome of 30 maxillary sinus floor augmentations with an autogenous bone-deproteinized bovine bone mixture (20:80). A total of 108 dental implants were placed after 6 months of graft healing. After another 6 months, the occlusion was restored with fixed prostheses and followed for 3 years of functional loading. Clinical and radiographic examinations of the sinuses and implants, including computerized tomography (CT) were performed. The stability of the implants was evaluated by means of resonance frequency analyses (RFA). After 3 years of functional loading with fixed bridges, 15 of 108 implants were lost giving a cumulative survival rate (CSR) of 86%. All followed patients, except one, had fixed bridges in function after 3 years of loading. The mean marginal bone loss was 1.3+/-1.1 mm after 3 years. RFA showed a mean implant stability quotient (ISQ) value of 66+/-4.1 after 3 years with no significant difference between implants in grafted and residual bone. Examination with CT showed that 67% of the maxillary sinuses were healthy prior to treatment and 71% after 3 years of loading. It was concluded that grafting of the maxillary sinus with a mixture of autogenous bone and deproteinized bovine bone is a reliable procedure.

  • 12.
    Hallman, Mats
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Cederlund, Andreas
    Lindskog, Sven
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi. Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Sennerby, Lars
    A clinical histologic study of bovine hydroxyapatite in combination with autogenous bone and fibrin glue for maxillary sinus floor augmentation. Results after 6 to 8 months of healing.2001Ingår i: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 12, nr 2, s. 135-143Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Biopsies were taken from 16 out of 20 consecutive referral patients 6 to 8 months after maxillary sinus floor augmentation with a mixture of bovine hydroxyapatite (BH), autogenous bone particles and fibrin glue. Four days prior to biopsy retrieval the patients were given a single dose of tetracycline to label bone forming sites. Fluorescence microscopy of 100 microm thick sections revealed active bone formation in conjunction with the BH particles in 14 of 15 specimens analysed. Light microscopy and morphometry of ground sections from 16 patients showed various amounts of mineralised bone tissue in all except one specimen. In the latter case, the BH particles were encapsulated by a dense fibrous connective tissue. Sections from the augmented areas were occupied by non-mineralized tissue (54.1+12.6%), lamellar bone (21.2+24.5%), BH particles (14.5+10.3%) and woven bone (10.2+13.4%). The non-mineralized tissue seen in bone forming areas consisted of a loose connective tissue, rich of vessels and cells, and in the periphery of a more dense fibrous connective tissue. Woven bone with large and scattered osteocyte lacunae was bridging between the BH particles and the lamellar trabecular bone. There were no signs of resorption of the BH particles. The lamellar bone appeared to have originated from the recipient site and was seldom in contact with the BH particles. It is concluded that the tested implant material has bone conducting properties. The bone associated with the BH particles after 6 to 8 months of healing was mainly woven.

  • 13.
    Hallman, Mats
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Hedin, Måns
    Sennerby, Lars
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi. Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    A prospective 1-year clinical and radiographic study of implants placed after maxillary sinus floor augmentation with bovine hydroxyapatite and autogenous bone.2002Ingår i: Journal of oral and maxillofacial surgery (Print), ISSN 0278-2391, E-ISSN 1531-5053, Vol. 60, nr 3, s. 277-284; discussion 285Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: The purposes of this study were 1) to evaluate the survival rate of implants placed in maxillary sinuses augmented with bovine hydroxyapatite and autogenous bone 6 months before implant surgery and 2) to estimate dimensional changes of the bone graft with time using a new radiographic method. PATIENTS AND METHODS: Thirty maxillary sinuses in 20 consecutive patients with severe resorption (mean, 3.8 mm of remaining alveolar bone) were augmented with a mixture of 80% bovine hydroxyapatite and 20% autogenous bone mixed with fibrin glue to enable the placement of screw-shaped dental implants. After 6 months of primary healing, 108 implants were placed and followed with clinical and radiographic examinations during the first year of loading. Measurements of changes in height, width, and length of the grafted material were made on tomographic Scanora (Soredex Orion Corporation Ltd, Helsinki, Finland) and panoramic radiographs taken 3 and 12 months after grafting and after 1 year of bridge loading. RESULTS: Ten implants in 6 patients were lost during the study (9 before loading and 1 after 1 year of functional loading), for a survival rate of 90.7%. All patients received fixed restorations, and the bridge survival rate was 100% after 1 year of loading. Small (<10%) but statistically significant dimensional changes in the grafted material were seen during the study period. CONCLUSIONS: Acceptable short-term results can be obtained with implants placed after the use of bovine hydroxyapatite and autogenous bone for maxillary sinus floor augmentation. These grafts show good resistance to resorption.

  • 14.
    Hallman, Mats
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture.2002Ingår i: International Journal of Oral & Maxillofacial Implants, ISSN 0882-2786, E-ISSN 1942-4434, Vol. 17, nr 5, s. 635-643Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: This study was designed to clinically and histologically evaluate the integration of titanium implants in different grafting materials used for maxillary sinus augmentation procedures. MATERIALS AND METHODS: A total of 21 patients and 36 maxillary sinuses were augmented with (1) autogenous particulated bone from the mandibular ramus, (2) bovine hydroxyapatite (BH) with membrane coverage, or (3) an 80/20 mixture of BH and autogenous bone. The grafts were allowed to heal for 6 to 9 months prior to placement of microimplants for histology and standard implants for prosthetic rehabilitation. After another 6 months of healing, when abutments were connected, the microimplants were retrieved for histologic and morphometric analyses. The outcome of the standard implants was clinically evaluated after 1 year of loading. RESULTS: The mean bone-implant contact was 34.6 +/- 9.5%, 54.3 +/- 33.1%, and 31.6 +/- 19.1% for autogenous bone, mixture of 20% autogenous bone/80% BH, and 100% BH, respectively. The corresponding values for the bone area parameter were 37.7 +/- 31.3%, 39.9 +/- 8%, and 41.7 +/- 26.6%. The BH area was found to be 12.3 +/- 8.5% and 11.8 +/- 3.6% for 20% autogenous bone/80% BH and 100% BH, respectively. There were no statistically significant differences for any parameter between any of the groups. After 1 year of loading, 6 of the 33 implants placed in autogenous bone grafts, 2 of the 35 implants placed in the BH/autogenous bone mixture, and 2 of 43 implants placed in BH were lost. There were no statistically significant differences between any of the groups. DISCUSSION: The histomorphometric analysis showed no differences between the 3 groups, indicating that autogenous bone graft can be substituted with bovine hydroxyapatite to 80% or 100% when used for maxillary sinus floor augmentation. The effect of adding autogenous bone remains unclear but may allow for a reduction of the healing time. CONCLUSION: The results from this clinical and histologic study indicate that similar short-term results can be expected when using autogenous bone, BH, or a mixture of them for maxillary sinus floor augmentation and delayed placement of dental implants.

  • 15.
    Hatano, N
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Sennerby, L
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi.
    Maxillary sinus augmentation using sinus membrane elevation and peripheral venous blood for implant-supported rehabilitation of the atrophic posterior maxilla: case series.2007Ingår i: Clinical implant dentistry and related research, Vol. 9, nr 3, s. 150-5Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Dental implants need appropriate bone volume for adequate stability in the rehabilitation after tooth loss. In the severely atrophic posterior maxilla, the clinical success of implant treatment sometimes requires a vertical ridge augmentation in the maxillary sinus floor. PURPOSE: The purpose of this investigation was to evaluate a maxillary sinus floor augmentation technique using a replaceable bone window, elevation of the membrane, placement of implants, and injection of the patient's own venous blood to fill the voids. MATERIALS AND METHODS: Six patients with need of maxillary sinus floor augmentation participated in the study. After preparation of a replaceable bone window in the lateral aspect of the sinus and careful elevation of the Schneiderian membrane, a total of 14 Brånemark implants (TiUnite, MK III, Nobel Biocare AB, Göteborg, Sweden) were installed in the residual bone penetrating into the sinus cavity. The sinus cavity was then filled with peripheral venous blood and the bone window replaced and stabilized with a medical tissue glue (Aron Alpha A, Sankyo, Inc., Tokyo, Japan) to prevent blood leakage from the created compartment in the maxillary sinus. RESULTS: After a healing period of a minimum of 6 months, new bone was successfully generated in all 14 implant sites as judged from radiographs. One of the 14 implants failed, corresponding to a survival rate of 92.9% after a follow-up period ranging 12 to 34 months. CONCLUSIONS: The present case series demonstrate that the creation of a secluded space in the maxillary sinus and filling with venous blood results in bone formation at simultaneously installed dental implants over a 6-month period.

  • 16.
    Jungner, Måns
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Stockholm, Sweden.
    Cricchio, Giovanni
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Salata, Luiz A
    Department of Oral & Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Sennerby, Lars
    Department of Oral and Maxillofacial Surgery, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
    Lundqvist, Carina
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Hultcrantz, Malou
    Department of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    On the early mechanisms of bone formation after maxillary sinus membrane elevation: an experimental histological and immunohistochemical study2015Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 17, nr 6, s. 1092-1102Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Previous studies have shown predictable bone formation in the maxillary sinus after membrane elevation. However, how and where the bone is formed is not well understood.

    Purpose: The aim of the study was to histologically and immunohistochemically study the early bone formation events in primates after membrane elevation in the maxillary sinus.

    Materials and Methods: Nine adult male tufted capuchin primates (Cebus apella) were included in the study. Eight animals were subjected to bilateral maxillary sinus membrane elevation using a lateral replaceable bone window technique. One oxidized dental implant was placed into the maxillary sinus cavity on both sides. In four animals, one sinus was left without any additional treatment, whereas the contralateral sinus was filled with autologous bone grafts from the tibia. In two animals, the implants were inserted under the elevated sinus membrane on both sides. In two animals, the sinus membrane was totally removed. The animals were euthanized after 10 or 45 days. One nonoperated animal representing pristine tissue conditions served as control. The maxillary sinuses with implants were retrieved and further processed for light microscopic ground sections or decalcified sections for immune-histochemical analyses.

    Results: Bone formation started from the bottom of the sinus floor, sprouting into the granulation tissue along the implant surface under the elevated membrane irrespective of time and surgical technique. Bone formation was not seen in direct conjunction with the sinus membrane. A distinct expression of osteopontin was observed in the serous glands of the lamina propria close to the implant within all groups.

    Conclusion: Bone formation after sinus membrane elevation with or without additional bone grafts starts at the sinus floor and sprouts into the elevated space along the implant surface. The sinus membrane does not seem to present osteoinductive potential in sinus membrane elevation procedures in this study.

  • 17.
    Jungner, Måns
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi. Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Stockholm, Sweden.
    Legrell, Per Erik
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Oral diagnostisk radiologi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Follow-up study of implants with turned or oxidized surfaces placed after sinus augmentation2014Ingår i: International Journal of Oral & Maxillofacial Implants, ISSN 0882-2786, E-ISSN 1942-4434, Vol. 29, nr 6, s. 1380-1387Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To compare long-term survival and clinical outcomes of endosseous implants with different surface characteristics in patients with sinus elevation procedures, autologous bone grafting, and delayed implant placement. Materials and Methods: Implant survival, peri-implant soft tissue conditions, marginal bone level, intrasinus apical bone level, and sinus health were studied in patients subjected to autologous bone graft and delayed placement of implants with turned or oxidized surfaces. After a minimum of 5 years of functional loading, all patients were clinically examined regarding gingival pocket depth (PD) and bleeding on probing (BoP). The marginal bone level (MBL) was measured in intraoral radiographs. Cone beam computed tomography was used to evaluate the apical bone level (ABL) of the implants and intrasinus conditions. Results: Twenty-eight patients received sinus elevation and a total of 92 dental implants. Thirteen patients received 47 implants with a turned surface, and 15 patients received 45 implants with an oxidized surface. Mean follow-up was 10 years (range, 5 to 19 years). No significant difference was found between the two implant surfaces in terms of PD, BoP, MBL, or ABL. Four patients (14%) exhibited radiographic signs of sinus pathology, with opacification, polyplike structures, and thickening of the sinus membrane. Radiographic signs of sinus pathology were not correlated to implant survival or to the investigated parameters. Conclusion: Grafting of the maxillary sinus floor with intraorally harvested bone and delayed placement of either turned or oxidized implants results in equally high long-term survival rates, stable marginal and apical bone levels, and good peri-implant soft tissue health.

  • 18.
    Jungner, Måns
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Legrell, Per-Erik
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Apical and marginal bone levels in patients rehabilitated with maxillary sinus floor augmentation using particulated mandibular bone graft and delayed placement of implants with two different surfaces. A minimum 5-year clinical and radiologic follow up in 28 patients.Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Purpose: To compare healing of endosseous implants with different surface characteristics in patients with sinus elevation procedures, autologous bone graft and delayed implant installation. Implant survival, peri-implant soft tissue conditions, marginal bone level, intra-sinus apical bone level and sinus health were studied.

    Material and Methods: Twenty-eight patients were subjected to autologous bone graft and delayed implant placement, with a total of 92 dental implants. Thirteen patients received 47 implants with a turned surface and 15 patients received 45 implants with an oxidized surface. After a minimum of 5 years of functional loading (mean 10 years, range 5 - 19 years), all patients were clinically examined regarding gingival pocket depth (PD) and bleeding on probing (BoP). The marginal bone level (MBL) was measured in intraoral radiographs. A cone beam computed tomography (CBCT) was used for evaluating the apical bone level (ABL) of the implants and intrasinus conditions.

    Results: No significant difference was found between the two implants surfaces used in terms of PD, BoP, MBL or ABL. Pathological reactions to the sinus membrane was seen in four of the patients (14%). Radiographic signs of sinus pathology were not correlated to either survival rate of the implants nor the investigated parameters. Conclusion: Grafting of the maxillary sinus floor with intra-orally harvested bone and delayed placement of either turned or oxidized implants results in equally high long-term survival rates, stable marginal and apical bone levels and good peri-implant soft tissue health.

  • 19. Jungner, Måns
    et al.
    Lundqvist, P
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Oxidized titanium implants (Nobel Biocare TiUnite) compared with turned titanium implants (Nobel Biocare mark III) with respect to implant failure in a group of consecutive patients treated with early functional loading and two-stage protocol.2005Ingår i: Clinical Oral Implants Research, Vol. 16, nr 3, s. 308-12Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVES: The purpose of this study was to compare two implant types of similar shape but with different surfaces with respect to implant failure. MATERIAL AND METHODS: A total of 136 patients were treated with Nobel Biocare Implants between January 2001 and December 2002. Totally 394 implants were placed, of which 199 were oxidized titanium implants (Nobel Biocare TiUnite and 195 with turned titanium surface (Nobel Biocare Mark III. Sixty-three patients underwent a one-stage surgical protocol, of which 24 were objected to early functional loading. The remaining 73 patients were treated with a traditional two-stage surgical protocol. All patients were followed for a minimum of 5 months after loading of the implants. Implants were classified as survivals when clinically stable and fulfilling purported function without any discomfort to the patient, with no signs of infection or ongoing pathologic process. RESULTS: Seven implants were lost in five patients (two males and three females), six in the maxilla and one in the mandible. All failed implants were Mark III implants, inserted following the traditional two-stage protocol. The implant success rate was 98.2% for the whole-patient group, divided as a 100% success rate following the implants with oxidized surface (Nobel Biocare TiUnite compared with a success rate of 96.4% with implants with turned surface (Nobel Biocare Mark III).

  • 20.
    Jungner, Måns
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Karolinska Univ Hosp, Dept Oral & Maxillofacial Surg, SE-17176 Stockholm, Sweden.
    Lundqvist, Peter
    Umeå Implant Center, Umeå, Sweden.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    A retrospective comparison of oxidized and turned implants with respect to implant survival, marginal bone level and peri-implant soft tissue conditions after at least 5 years in function2014Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 16, nr 2, s. 230-237Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Long-term clinical follow-up studies comparing different implant surfaces with regard to survival and marginal conditions are rare. Objectives: The objective of this study was to compare the clinical performance of turned and oxidized implants after more than 5 years of loading Material and Methods: One hundred three patients (43 men, 60 women; mean age 67.4 years, range 32–90) previously treated with 287 implants (Nobel Biocare AB, Gothenburg, Sweden), 133 with turned surface (MKIII, Nobel Biocare AB) and 154 with an oxidized surface (MKIII, TiUnite, Nobel Biocare AB) were examined after at least 5 years of loading (mean 82 months, range 60–93 months). The implants had been used for support of single crowns (33 patients/36 implants), partial bridges (39 patients/103 implants), or full bridges (31 patients/148 implants) following an early loading protocol (14 patients /54 implants), a one-stage protocol (32 patients/59 implants) or a two-stage protocol (57 patients/174 implants). Clinical examinations of bleeding on probing (BoP) and pocket depth (PD) were performed. Intraoral radiographs were used for assessments of marginal bone levels (MBLs). Results: Seven turned implants and one oxidized implant failed, giving overall cumulative survival rates of 94.7 and 99.4%, respectively. There were no differences for BoP scores (0.5 1 0.7 vs 0.4 1 0.6) and PD measurements (1.7 1 0.8 mm vs 1.8 1 1.0 mm) parameters when comparing turned and oxidized implants, respectively. The mean MBL was 1.8 1 0.8 mm and 2.0 1 0.9 mm for turned and oxidized implants, respectively, after more than 5 years in function (NS). Frequency distribution of MBL loss showed no statistically significant differences between the two surfaces. A total of four implants (1.4%) (three oxidized and one turned) showed a PD > 3 mm, MBL > 4 mm, and BoP. However, none of these were associated with suppuration on examination. Conclusion: The present study does not state any differences in implant failure, MBL, presence of bleeding or PD around implants when comparing turned and oxidized titanium implants after at least 5 years of function. 

  • 21.
    Jungner, Måns
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Lundqvist, Peter
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Oxidized titanium implants (Nobel Biocares TiUnite) compared with turned titanium implants (Nobel Biocares mark III) with respect to implant failure in a group of consecutive patients treated with early functional loading and two-stage protocol2005Ingår i: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 16, nr 3, s. 308-312Artikel i tidskrift (Refereegranskat)
  • 22.
    Lundgren, Sofia
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Johansson, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Cricchio, Giovanni
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Studio Odontoiatrico Associato "Passaggio dei Poeti", Palermo, Italy.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Clinical outcome and factors determining new bone formation in lateral sinus membrane elevation with simultaneous implant placement without grafting material: a cross‐sectional, 3‐17 year follow‐up study2019Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 21, nr 5, s. 827-834Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Lateral sinus membrane elevation with simultaneous implant placement without grafting material (graft‐less LSFE) is a widely investigated method for bone augmentation of the maxillary sinus floor. Long‐term follow‐up studies are rare.

    Purpose: This study aimed to investigate the long‐term effects of implants placed with graft‐less LSFE.

    Materials and methods: The study group was comprised of 111 patients previously treated with graft‐less LSFE. The first follow‐up visit, which occurred after a mean of 5 years after surgery, included a clinical examination, cone beam computerized tomography, and panorama or intraoral radiography. The second follow‐up included panorama or intraoral radiography, and it was conducted after a mean of 8 years.

    Results: Overall, 218 implants were placed in 127 sinuses. Nine of the 218 implants failed resulting in an overall implant survival of 95.9%. The average bone gain at the follow‐up was 4.0 ±2.0 mm.

    Conclusion: The implant‐supported rehabilitation achieved using graft‐less LSFE was stable over time, and there was no or little impact on sinus health. Furthermore, it was concluded that the new bone formation and the amount of bone gain is proportional to the length of the implant protruding into the sinus cavity.

  • 23.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Andersson, S
    Gualini, F
    Sennerby, L
    Bone reformation with sinus membrane elevation: a new surgical technique for maxillary sinus floor augmentation.2004Ingår i: Clinical Implant Dentistry and Related Research, Vol. 6, nr 3, s. 165-73Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Various maxillary sinus floor augmentation techniques using bone grafts and bone substitutes are frequently used to enable placement of dental implants in the posterior maxilla. A previous case report demonstrated the possibility of promoting bone formation in the sinus by lifting the membrane without using a grafting material. However, the predictability of the technique is not known. PURPOSE: The aim of this study was to investigate whether sinus membrane elevation and the simultaneous insertion of titanium implants without additional grafting material constitute a valid technique for bone augmentation of the maxillary sinus floor. MATERIALS AND METHODS: The study group comprised 10 patients in whom a total of 12 maxillary sinus floor augmentations were performed. A replaceable bone window was prepared in the lateral sinus wall with a reciprocating saw. The sinus membrane was dissected, elevated superiorly, and sutured to the sinus wall to create and maintain a compartment for blood clot formation. One to three dental implants were inserted through the residual bone and protruded at least 5 mm into the maxillary sinus. The bone window was replaced and secured with the overlying mucosa. Bone height was measured directly at each implant site at the time of insertion. Resonance frequency analysis (RFA) was performed on each implant at the time of initial placement, at abutment surgery, and after 12 months of functional loading. Computed tomography (CT) was performed in the immediate postoperative period and 6 months later, prior to exposure of the implants. RESULTS: A total of 19 implants (Brånemark System, TiUnite, Nobel Biocare AB, Gothenburg, Sweden) in lengths of 10 to 15 mm were placed, with an average residual bone height of 7 mm (range, 4-10 mm). All implants remained clinically stable during the study period. Comparisons of pre- and postoperative CT radiography clearly demonstrated new bone formation within the compartment created by the sinus membrane elevation procedure. RFA measurements showed mean implant stability quotient values of 65, 66, and 64 at placement, at abutment connection, and after 12 months of loading, respectively. CONCLUSIONS: The study showed that there is great potential for healing and bone formation in the maxillary sinus without the use of additional bone grafts or bone substitutes. The secluded compartment created by the elevated sinus membrane, implants, and replaceable bone window allowed bone formation according to the principle of guided tissue regeneration. The precise mechanisms are not known, and further histologic studies are needed. Sinus membrane elevation without the use of additional graft material was found to be a predictable technique for bone augmentation of the maxillary sinus floor.

  • 24.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Andersson, S
    Sennerby, L
    Spontaneous bone formation in the maxillary sinus after removal of a cyst: coincidence or consequence?2003Ingår i: Clinical Implant Dentistry and Related Research, Vol. 5, nr 2, s. 78-81Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Maxillary sinus floor-augmentation techniques are frequently used to increase the bone volume in the posterior edentulous maxilla to enable placement and integration of titanium implants. PURPOSE: The purpose of this report is to document an unexpected healing pattern after maxillary sinus surgery and to discuss the implications for future bone-augmentation techniques. MATERIALS AND METHODS: In a patient referred for sinus augmentation, an intrasinus mucosal cyst was removed 3 months prior to the planned augmentation procedure. A replaceable bone window was prepared in the lateral aspect of the sinus wall. The cyst was removed, the ruptured mucosa was sutured, and the bone window was replaced, resulting in a secluded space in the sinus. RESULTS: After 3 months of healing, the space between the replaced bony window and the lifted sinus membrane was filled with newly formed bone. The surgical technique was repeated in a second patient and resulted in a similar bone reformation pattern. CONCLUSION: Surgical trauma and the creation of a secluded space between the bone surfaces and the sinus mucosa result in spontaneous bone formation in the maxillary sinus. The surgical approach described may be used to achieve bone reformation to enable placement of dental implants without the addition of any grafting material.

  • 25.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Cricchio, Giovanni
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Hallman, Mats
    Jungner, Måns
    Rasmusson, Lars
    Sennerby, Lars
    Sinus floor elevation procedures to enable implant placement and integration: techniques, biological aspects and clinical outcomes2017Ingår i: Periodontology 2000, ISSN 0906-6713, E-ISSN 1600-0757, Vol. 73, nr 1, s. 103-120Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Implant treatment in an atrophied edentulous posterior maxilla constitutes a challenge for the therapeutic team. The authors of the present study acknowledge that modern micro-rough surface implants in lengths of about 8-10 mm or longer and of different brands are similarly successful. Consequently, the authors propose that the use of different sinus floor elevation techniques should be considered when < 8 mm of bone is available below the maxillary sinus. The type of sinus floor elevation technique selected is mainly based on residual vertical bone height, marginal bone width, local intrasinus anatomy and the number of teeth to be replaced, although other factors (such as surgical training and surgical experience) may have an impact. It is proposed that a transcrestal sinus floor elevation approach can be considered as a first-choice method for single tooth gaps in situations with sufficient width for implant placement and a residual bone height of 5-8 mm, while lateral sinus floor elevation, with or without grafting materials, is indicated when < 5 mm of bone is available and when several teeth are to be replaced. With regard to time of implant placement, a one-stage procedure is preferred provided that high primary stability can be ensured.

  • 26.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Cricchio, Giovanni
    Palma, Vinicius C
    Salata, Luiz A
    Sennerby, Lars
    Sinus membrane elevation and simultaneous insertion of dental implants: a new surgical technique in maxillary sinus floor augmentation.2008Ingår i: Periodontology 2000, ISSN 0906-6713, E-ISSN 1600-0757, Vol. 47, s. 193-205Artikel i tidskrift (Refereegranskat)
  • 27.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Nyström, Elisabeth
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Nilson, Hans
    Umeå universitet, Medicinsk fakultet, Odontologi, Protetik.
    Gunne, Johan
    Umeå universitet, Medicinsk fakultet, Odontologi, Protetik.
    Lindhagen, O
    Bone grafting to the maxillary sinuses, nasal floor and anterior maxilla in the atrophic edentulous maxilla. A two-stage technique.1997Ingår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 26, nr 6, s. 428-434Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study presents the results from 20 consecutive patients treated with an autogenous bone graft from the iliac crest. In ten patients the graft was placed in the maxillary sinuses and the floor of the nose (inlay group). Ten patients, in addition to the inlay graft, had a corticocancellous bone block secured with mini-screws to the anterior maxillary ridge (inlay/onlay group). Endosteal implants (Brånemark) were placed six months after surgery. A total of 136 implants were placed, of which eight failed to integrate during the six-month healing period. A further 15 implants were lost during the follow-up period. For the inlay group the average follow-up period was 22 months and for the inlay/onlay group 19 months. Donor site morbidity was significantly less when iliac bone was harvested with a trephine (inlay group) than in patients treated with our routine procedure for bone harvesting (inlay/onlay group). Surgical technique, donor site morbidity, implant survival and patient acceptance are presented.

  • 28.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Nyström, Elisabeth
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Sennerby, Lars
    Sjöström, Mats
    Brechter, Magnus
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Nilson, Hans
    Öberg, Sven
    Lundqvist, Peter
    Jungner, Måns
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Tidehag, Per
    Gunne, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Rekonstruktiv käkkirurgi 2: Behandling av den tandlösa atrofiska maxillan2008Ingår i: Tandläkartidningen, ISSN 0039-6982, Vol. 100, nr 5, s. 72-73Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 29.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Rasmusson, Lars
    Sjöström, Mats
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Sennerby, Lars
    Simultaneous or delayed placement of titanium implants in free autogenous iliac bone grafts: Histological analysis of the bone graft-titanium interface in 10 consecutive patients1999Ingår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 28, nr 1, s. 31-37Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of the present study was to histologically analyse the bone graft-titanium implant interface after six and twelve months of healing for a simultaneous approach and after six months for a delayed approach. For this purpose, screw-shaped c.p. titanium microimplants, 2 mm in diameter and 5 mm long, were placed and retrieved at different time intervals in ten consecutive patients with severely resorbed maxillae and treated with iliac cortico-cancellous bone grafts and titanium implants in a two-stage procedure. The histomorphometrical analyses of ground sections of the specimens showed a higher degree of bone-implant contact and more bone filling the implant threads in the delayed approach microimplants. This was probably due to the partly revascularized grafted bone in the delayed approach being able to respond to the surgical trauma, resulting in interfacial bone formation. It is concluded that the results from the present study favour the use of a delayed approach when using free autogenous bone grafts and titanium implants for reconstruction of the severely atrophied maxilla.

  • 30.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Bone reformation: Contemporary augmentation procedures in oral and maxillofacial implant surgery2008 (uppl. 1)Bok (Övrigt vetenskapligt)
  • 31.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Bone reformation: Contemporary augmentation procedures in oral and maxillofacial implant surgery2010 (uppl. 1)Bok (Övrigt vetenskapligt)
  • 32.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Sennerby, Lars
    Cricchio, Giovanni
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Salata, Luiz
    Palma, Vinnie
    Lundqvist, Carina
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Ransjö, Maria
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Rekonstruktiv käkkirurgi: Behandling av den atrofiska posteriora maxillan hos partiellt betandade patienter2008Ingår i: Tandläkartidningen, ISSN 0039-6982, Vol. 100, nr 5, s. 70-71Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 33.
    Lundgren, Stefan
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi. Umeå universitet, Medicinsk fakultet, Odontologi.
    Sjöström, Mats
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi. Umeå universitet, Medicinsk fakultet, Odontologi.
    Nyström, Elisabeth
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi. Umeå universitet, Medicinsk fakultet, Odontologi.
    Sennerby, Lars
    Strategies in reconstruction of the atrophic maxilla with autogenous bone grafts and endosseous implants.2008Ingår i: Periodontology 2000, ISSN 1600-0757, Vol. 47, s. 143-61Artikel i tidskrift (Refereegranskat)
  • 34.
    Nyström, Elisabeth
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Gunne, Johan
    Umeå universitet, Medicinsk fakultet, Odontologi, Protetik.
    Nilson, Hans
    Umeå universitet, Medicinsk fakultet, Odontologi, Protetik.
    Interpositional bone grafting and Le Fort I osteotomy for reconstruction of the atrophic edentulous maxilla. A two-stage technique.1997Ingår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 26, nr 6, s. 423-427Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study presents the results from ten consecutive patients who, because of insufficient bone volume for conventional implant placement in the maxilla, were treated with an interpositional bone graft and Le Fort I osteotomy. The endosteal implants were placed six months after the osteotomy. A total of 60 screw-shaped titanium implants (Brånemark) were placed, of which three failed to integrate during the six-month healing period. No further implants were lost during the follow-up period, ranging from 15 to 39 months after placement of the implants. All patients received fixed bridges and all have continued to function efficiently.

  • 35.
    Nyström, Elisabeth
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Nilson, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Gunne, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    A 9-14 year follow-up of onlay bone grafting in the atrophic maxilla.2009Ingår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 38, nr 2, s. 111-116Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Treatment of the atrophic edentulous maxilla is challenging especially when bone graft procedures are necessary. In this study an onlay bone graft, a saddle or veneer, with or without maxillary sinus floor inlay graft, harvested from the anterior iliac crest, in combination with implants was used in the reconstruction of patients with extreme atrophy in their maxillae. The aim was to investigate treatment outcome, and the impact of gender and smoking, in 44 patients in a prospective, long-term, follow-up study concerning implant survival rate and marginal bone loss adjacent to the surfaces of the implant. Mean follow-up time was 11 years. Of 334 inserted Brånemark implants, with machined surface, 27 failed. Estimated implant survival rate was 90%. Marginal bone loss was 1.8 mm 1 year after implant surgery; 2.3 mm after 5 years; and 2.4 mm after 10 years. There was a significant difference between genders in implant survival. Marginal bone loss differed significantly between smokers and non-smokers up to the 5-year examination and between genders after the 4-year examination. The onlay bone graft, with or without a maxillary inlay graft, results in high implant survival rate, good oral function and stabilised marginal bone. All patients are still wearing their original fixed bridges.

  • 36.
    Nyström, Elisabeth
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Nilson, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Gunne, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Reconstruction of the atrophic maxilla with interpositional bone grafting/Le Fort I osteotomy and endosteal implants: A 11-16 year follow-up.2009Ingår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 38, nr 1, s. 1-6Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A Le Fort I osteotomy and interpositional bone graft in combination with implants was used in the reconstruction of patients with extreme atrophy in their maxillae. Surgery was performed in a two-stage procedure. The patients in this study had conditions with reversed intermaxillary relationships with or without increased vertical intermaxillary distance. The aim of the study was to investigate treatment outcome for patients in a prospective, long-term, follow-up with a mean of 13 years (range 11-16 years), concerning implant survival rate and marginal bone loss adjacent to the surfaces of the implant. The impact of gender and smoking was also investigated. Twenty-six patients were included in the study. Of 167 implants, 24 failed. The implant estimated survival rate was 85% at the end of the follow-up. There was no significant difference between smokers and non-smokers or genders concerning implant survival. Marginal bone loss was 2.5, 2.9, 3.0 and 3.1mm from the implant-abutment junction, after 1, 2, 5 and 10 years, respectively. The bone level stabilised after 2 years. This technique results in good facial morphology, good oral function and aesthetics. All patients are still wearing their original fixed bridges.

  • 37. Palma, VC
    et al.
    Magro-Filho, O
    de Oliveria, JA
    Lundgren, Stefan
    Umeå universitet, Medicinsk fakultet, Odontologi, Käkkirurgi.
    Salata, LA
    Sennerby, L
    Bone reformation and implant integration following maxillary sinus membrane elevation: an experimental study in primates.2006Ingår i: Clinical Implant Dental Related Research, Vol. 8, nr 1, s. 11-24Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Recent clinical studies have described maxillary sinus floor augmentation by simply elevating the maxillary sinus membrane without the use of adjunctive grafting materials. PURPOSE: This experimental study aimed at comparing the histologic outcomes of sinus membrane elevation and simultaneous placement of implants with and without adjunctive autogenous bone grafts. The purpose was also to investigate the role played by the implant surface in osseointegration under such circumstances. MATERIALS AND METHODS: Four tufted capuchin primates had all upper premolars and the first molar extracted bilaterally. Four months later, the animals underwent maxillary sinus membrane elevation surgery using a replaceable bone window technique. The schneiderian membrane was kept elevated by insertion of two implants (turned and oxidized, Branemark System, Nobel Biocare AB, Goteborg, Sweden) in both sinuses. The right sinus was left with no additional treatment, whereas the left sinus was filled with autogenous bone graft. Implant stability was assessed through resonance frequency analysis (Osstell, Integration Diagnostics AB, Goteborg, Sweden) at installation and at sacrifice. The pattern of bone formation in the experimental sites and related to the different implant surfaces was investigated using fluorochromes. The animals were sacrificed 6 months after the maxillary sinus floor augmentation procedure for histology and histomorphometry (bone-implant contact, bone area in threads, and bone area in rectangle). RESULTS: The results showed no differences between membrane-elevated and grafted sites regarding implant stability, bone-implant contacts, and bone area within and outside implant threads. The oxidized implants exhibited improved integration compared with turned ones as higher values of bone-implant contact and bone area within threads were observed. CONCLUSIONS: The amount of augmented bone tissue in the maxillary sinus after sinus membrane elevation with or without adjunctive autogenous bone grafts does not differ after 6 months of healing. New bone is frequently deposited in contact with the schneiderian membrane in coagulum-alone sites, indicating the osteoinductive potential of the membrane. Oxidized implants show a stronger bone tissue response than turned implants in sinus floor augmentation procedures.

  • 38.
    Ransjö, Maria
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Oral cellbiologi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Det växer fast - om implantat och benbildning.: På bettet hela livet, om  odontologisk vetenskap i Umeå. pp2006Ingår i: På bettet hela livet, om  odontologisk vetenskap i Umeå.: En bok från Forskningens dag 2006, Medicinska fakulteten, Umeå universitet. Författare Svante Twetman / [ed] Medicinska fakulteten vid Umeå universitet, Umeå: Umeå universitet , 2006, s. 67-82Kapitel i bok, del av antologi (Övrig (populärvetenskap, debatt, mm))
  • 39. Sennerby, Lars
    et al.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Rasmusson, Lars
    Benaugmentation i samband med implantatbehandling: En teknik- och litteraturöversikt2010Ingår i: Tandläkartidningen, ISSN 0039-6982, Vol. 102, nr 2, s. 64-73Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 40.
    Sjöström, Mats
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Nilson, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Sennerby, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Monitoring of implant stability in grafted bone using resonance frequency analysis: A clinical study from implant placement to 6 months of loading.2005Ingår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 34, nr 1, s. 45-51Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of this prospective study was to compare implants placed in grafted and normal non-grafted maxilla by means of resonance frequency analysis (RFA), clinical stability and implant failure. Twenty-nine patients with severe atrophy of the edentulous maxilla were treated with autogenous bone grafts as onlay (24 patients) or as interpositional grafts in conjunction with a Le Fort I osteotomy (five patients) 6 months prior to placement of 222 implants. Ten non-grafted patients treated with 75 Brånemark implants in the edentulous maxillae served as a control group. RFA was performed at implant placement, abutment connection and after 6 months of bridge loading. Seventeen (8%) implants were lost in the grafted bone and one (1%) in normal bone. RFA revealed a similar pattern in both grafted and normal maxillae, i.e. increasing resonance frequency (RF) with time (Wilcoxon Signed Rank test for paired data). Twenty implants that were rotation mobile (low primary stability) at the time of insertion showed a significantly lower value at implant placement according to RFA (Mann-Whitney U-test, P = 0.020). The RF for the failed implants revealed a tendency towards lower values (Mann-Whitney U-test, P = 0.072), compared to the successful implants. It is concluded that implants placed in grafted bone when using a two-stage technique achieve a stability similar to that of implants placed in normal non-grafted bone.

  • 41.
    Sjöström, Mats
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    A histomorphometric comparison of the bone graft-titanium interface between interpositional and onlay/inlay bone grafting techniques.2006Ingår i: International Journal of Oral & Maxillofacial Implants, ISSN 0882-2786, E-ISSN 1942-4434, Vol. 21, nr 1, s. 52-62Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: To analyze the bone graft-implant interface of titanium microimplants (MIs) placed at the time of bone grafting or after a healing period of 6 months and retrieved after another 6 to 14 months of healing. Integration of MIs placed in interpositional bone grafts (IBGs) in conjunction with a Le Fort I osteotomy was compared with the integration of those placed in onlay/inlay bone grafts (OBGs). MATERIALS AND METHODS: The severely atrophied edentulous maxillae of 23 patients (14 women, 9 men) were restored with autogenous bone grafts (either IBG [n=8] or OBG [n=15]) and titanium implants. Six-month periods were allowed between grafting, implant placement, and abutment connection. The bone-implant interface was studied histologically with the use of unloaded titanium MIs. RESULTS: Sixty-eight MIs were either (1) placed simultaneously with grafting and retrieved after 6, 12, or 14 months or (2) placed after 6 months of healing and retrieved after another 6 to 8 months. Histomorphometry indicated equal degrees of osseointegration for the 2 intraoral reconstruction techniques when looking at bone-implant contact, bone area in threads, and newly formed bone (NFB) (Student t test for unpaired observations). There was a significant difference between simultaneous and delayed implant placement with respect to BIC and NFB (Student t test for paired observations). Three additional MIs placed in the nongrafted residual alveolar ridge and retrieved after 6 months showed significantly more bone in threads and NFB (Student t test for paired observations; P = .003 and P = .009, respectively) compared to MIs placed at graft placement (6 months' healing). DISCUSSION: Timing of implant placement appeared more important than healing time or surgical technique. The delayed approach resulted in better implant integration, probably because of the initial revascularization of the graft. CONCLUSIONS: Implant integration was similar in the IBG and OBG groups. Placement of MIs after an initial healing period of 6 months resulted in better integration than placement simultaneously with grafting.

  • 42.
    Sjöström, Mats
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi. Department of Biomaterials/Handicap Research Institute for Surgical Sciences, Gothenburg University, Sweden.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Bone graft healing in reconstruction of maxillary atrophy2013Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 15, nr 3, s. 367-379Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Evaluate correlations between volume change for iliac crest bone grafts in maxillary reconstruction (graft volume change [GVC]) and bone mineral density (BMD), bone volume fraction (BVF), hematologic bone metabolic factors (I), and identify indicators of implant failure (II).

    Material and Methods: Forty-six consecutive patients had their edentulous atrophic maxilla reconstructed with free autogenous bone grafts from anterior iliac crest. Endosteal implants were placed 6 months after graft healing. Computer tomography was performed after 3 weeks and 6 months after grafting. Bone biopsies were taken from the internal table of donor site for calculation (BVF), and blood samples were collected. Implant stability was measured at placement with resonance frequency analysis and expressed as implant stability quotient (ISQ). Implant failure was registered.

    Results: GVC in onlay bone graft was 37%. The BVF in iliac crest biopsies was 32%. Serum-IGFBP3 differed with 79% of the samples over normal range. Fifteen patients had one or more implant failures prior to loading (early failures). Forty-two patients were followed for a minimum of 3 years after implant loading and, in addition, 6/42 patients had one or more implants removed during the follow-up (late failures). GVC correlated to decreased BMD of lumbar vertebrae L2-L4 (Kruskal-Wallis test, p=.017). No correlation was found between GVC and hematologic factors (Pearson correlation test) or between GVC and BVF (Kruskal-Wallis test). No correlation was found between ISQ and GVC (Pearson correlation test, p=.865). The association between implant failures and the described factors were evaluated, and no significant correlations were found (unconditional logistic regression).

    Conclusion: Onlay bone grafts decrease 37% during initial healing period, which correlate to BMD of lumbar vertebrae L2-L4. No other evaluated parameters could explain GVC. The evaluated factors could not explain implant failure.

  • 43.
    Sjöström, Mats
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Sennerby, Lars
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Influence of bone density and bone metabolic factors on the healing of bone grafts and implant failure in reconstruction of maxillary atrophyManuskript (Övrigt vetenskapligt)
  • 44.
    Sjöström, Mats
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Sennerby, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Nilson, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Protetik.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Käkkirurgi.
    Reconstruction of the atrophic edentulous maxilla with free iliac crest grafts and implants: a 3-year report of a prospective clinical study.2007Ingår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 9, nr 1, s. 46-59Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: The purpose of this study was to perform a longitudinal follow-up study of implant stability in grafted maxillae with the aid of clinical, radiological, and resonance frequency analysis (RFA) parameters. MATERIALS AND METHODS: The atrophic edentulous maxillae in 29 patients were reconstructed with free iliac crest grafts using onlay/inlay or interpositional grafting techniques. The endpoint of the resorption pattern in the maxilla determined the grafting technique used. Endosteal implants were placed after 6 months of bone-graft healing. Implant stability was measured four times using RFA: when the implants were placed, after 6 to 8 months of healing, after 6 months and 3 years of bridge loading. Individual checkups were performed at the two later RFA registrations after removal of the supraconstructions (Procera Implant Bridge, Nobel Biocare AB, Goteborg, Sweden). Radiological follow up of marginal bone level was performed annually. RESULTS: Twenty-five patients remained for the follow-up period. A total of 192 implants were placed and with a survival rate of 90% at the 3-year follow up. Women and an implant position with a class 6 resorption prior to reconstruction were factors with significant increased risk for implant failure (multivariate logistic regression). Twelve of the 20 failed implants were lost before loading (early failures). The change in the marginal bone level was 0.3 +/- 0.3 mm between baseline (bridge delivery) and the 3-year follow up. The implant stability quotient (ISQ) value for all implants differed significantly between abutment connection (60.2 +/- 7.3) and after 6 months of bridge loading (62.5 +/- 5.5) (Wilcoxon signed ranks test for paired data, p=.05) but were nonsignificant between 6 months of bridge loading and 3 years of bridge loading (61.8 +/- 5.5). There was a significant difference between successful and failed implants when the ISQ values were compared for individual implants at placement (Mann-Whitney U test, p=.004). All 25 patients were provided with fixed implant bridges at the time of the 3-year follow up. CONCLUSION: This clinical follow up using radiological examinations and RFA measurements indicates a predictable and stable long-term result for patients with atrophic edentulous maxillae reconstructed with autogenous bone and with delayed placement of endosteal implants. The ISQ value at the time of placement can probably serve as an indicator of level of risk for implant failure.

  • 45.
    Åkesson, Fredrik
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Zamure-Damberga, Liene
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Department of Conservative Dentistry and Oral Health, Faculty of Dentistry, Riga Stradins University, Riga, Latvia.
    Lundgren, Stefan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Sjöström, Mats
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Alveolar bone remodeling in virtually planned, bone-grafted vs non-grafted guided flapless implant surgery in the anterior maxilla: a cross-sectional retrospective follow-up study2023Ingår i: Oral and Maxillofacial Surgery, ISSN 1865-1550, E-ISSN 1865-1569, Vol. 27, nr 1, s. 43-52Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PURPOSE: In patients who underwent virtual planning and guided flapless implant surgery for teeth missing in the anterior maxilla, we compared buccal bone loss between those treated with and without autogenous bone augmentation.

    METHODS: Of 22 patients with teeth missing because of trauma or aplasia, 10 (18 implant sites) were reconstructed with buccally placed bone graft harvested from the mandibular ramus, and 12 were non-reconstructed (16 sites). Baseline cone-beam computed tomography allowed for implant planning using the NobelClinician® software and was performed again at 1 year after functional loading. The marginal bone level was assessed radiographically at post-implant baseline and at follow-up.

    RESULTS: At follow-up, buccal bone loss differed significantly between groups at the central level of the implant (p = 0.0005) but not at the coronal level (p = 0.329). The mean marginal bone level change was 0.6 mm, with no significant between-group difference (p = 0.876). The actual implant position often deviated in the vertical or sagittal plane by an average of 0.3-0.6 mm from the planned position.

    CONCLUSION: Compared with non-reconstructed patients, reconstructed patients experienced significantly more buccal bone loss at the central level of implants. The groups did not differ at the coronal level or in marginal bone loss, possibly because of the more augmented bone at the central level among reconstructed patients. Differences between planned versus actual implant positions should be considered in situations of limited bone volume at the planned implant site.

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