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  • 1.
    Ekici, Rifat
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry.
    B cells in Type 1 diabetes: studies on cell surface antibody binding2010Licentiate thesis, monograph (Other academic)
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  • 2.
    Renman, Emma
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    Ekici, Rifat
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    Sundström, Mia
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    Lejon, Kristina
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse2022In: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 55, no 8, p. 520-528Article in journal (Refereed)
    Abstract [en]

    B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

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