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  • 1.
    Deyessa Kabeta, Negussie
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
    Berhane, Y
    Emmelin, Maria
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Ellsberg, MC
    Kullgren, Gunnar
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
    Högberg, Ulf
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi.
    Joint effect of maternal depression and intimate partner violence on increased risk of child death in rural Ethiopia2010Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 95, nr 10, s. 771-775Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An awareness of the devastating consequences on child survival in low income setting of violence against women and depression is needed among public health workers as well as clinicians, for both community and clinical interventions.

  • 2.
    Falkenstein-Hagander, Kathy
    et al.
    Public Health Agency of Sweden, Solna, Sweden.
    Appelqvist, Emma
    Department of Public Health Analysis and Data Management, Public Health Agency of Sweden, Solna, Sweden.
    Frisk Cavefors, Ann-Sofie
    Central Child Health Services Unit, Gothenburg, Sweden.
    Källberg, Henrik
    Public Health Agency of Sweden, Solna, Sweden.
    Nilsson, Lennart Jan
    Allergy Center, Department of Biomedical and Clinical Sciences, Linkoping University, Linkoping, Sweden.
    Silfverdal, Sven-Arne
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Storsaeter, Jann
    Public Health Agency of Sweden, Solna, Sweden.
    Aronsson, Bernice
    Public Health Agency of Sweden, Solna, Sweden.
    Waning infant pertussis during COVID-19 pandemic2022Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 107, nr 3, artikel-id e19Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Measures to reduce the spread of COVID-19 have been associated with reduction in other respiratory infections. Results of a national Swedish cohort study of infant pertussis during April 2020-September 2021 were compared with those during January 2014-March 2020. The number of pertussis cases decreased significantly during the COVID-19 pandemic, from an average of 21 infant cases per quarter of a year before the pandemic to an average of 1 case per quarter during the pandemic. Swedish strategies to mitigate the spread of COVID-19 seem to have had an impact on pertussis incidence in infants. Measures to prevent the spread of COVID-19 have also reduced other respiratory viral infections in children. This study from Sewden found that the number of infant pertussis infections also fell during the COVID-19 pandemic. The authors discuss the implications of this finding.

  • 3.
    Larsson, Linn
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Challis, Pontus
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Späth, Cornelia
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Stoltz Sjöström, Elisabeth
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Domellöf, Magnus
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Blood transfusions are not a risk factor for necrotizing enterocolitis in extremely preterm infants2014Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 99, nr Suppl 2, s. A177-A177, artikel-id PS-183Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background:  Transfusion practices are highly variable between hospitals and previous studies have suggested that blood transfusions may increase the risk of necrotizing enterocolitis (NEC).

    Aim: To explore the association between blood transfusions and incidence of NEC in extremely preterm infants.

    Methods: We used data from a Swedish population-based study including extremely preterm infants (<27 weeks) born between 2004–2007, (n = 602). All data on blood transfusions and haemoglobin (Hb) concentrations up to 28 days of age was collected for survivors. We performed a nested case-control study where two controls were chosen for each case of NEC (n = 21).

    Results: During the first 28 days of life, infants received a median (25th-75th percentile) of 6 (3–9) blood transfusions resulting in 75 (44–120) ml/kg of blood. Predictors for receiving a higher volume of blood transfusions were days on respiratory support (R = 0.345, p < 0.001), hospital (R = 0.339, p < 0.001), low birth weight (R = -0.236, p < 0.001) and total steroid dose (R = 0.209, p < 0.001). Hb was not a significant predictor.

    Overall NEC incidence was 5.8%. There was no significant difference between NEC cases and controls in number of blood transfusions (p = 0.420), volume of blood transfused from birth to NEC diagnosis (p = 0.274), or during the 48 h preceding NEC diagnosis (p = 0.459).

    Conclusions: Blood transfusions were given liberally in Sweden compared to other studied populations. Morbidity related variables, especially those related to respiratory illness, were significant predictors of blood transfusion. NEC incidence was comparable with other populations but no significant association was found between blood transfusions and NEC among these extremely preterm infants.

  • 4. Larsson, Sara Marie
    et al.
    Hellström-Westas, Lena
    Hillarp, Andreas
    Karlsland Åkeson, Pia
    Domellöf, Magnus
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Askelöf, Ulrica
    Götherström, Cecilia
    Andersson, Ola
    Haemoglobin and red blood cell reference intervals during infancy2022Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 107, nr 4, s. 351-358Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives: There is a need for updated haematological reference data in infancy. This study aimed to define intervals for haemoglobin and red blood cell biomarkers based on data from a large cohort of longitudinally followed Swedish infants.

    Design: Longitudinal cohort study.

    Setting: Two Swedish study centres.

    Participants: Three community-based populations including 442 presumably healthy infants born at term and with umbilical cord clamping delayed to 30 s or more after birth.

    Methods: Blood samples were collected from umbilical cord blood (a), at 48-118 hours (b), at 4 months (c) and at 12 months (d). Reference intervals as the 2.5th and 97.5th percentiles were calculated in coherence with Clinical and Laboratory Standards Institute guidelines.

    Results: Reference intervals for haemoglobin (g/L) were: (a) 116-189, (b) 147-218, (c) 99-130, (d) 104-134, and for mean cell volume (fL): (a) 97-118, (b) 91-107, (c) 71-85, (d) 70-83. Reference intervals for erythrocyte counts, reticulocyte counts, reticulocyte haemoglobin, mean cell haemoglobin and mean cell haemoglobin concentration were also estimated. According to the WHO definition of anaemia, a haemoglobin value less than 110 g/L, 16% of this presumably healthy cohort could be classified as anaemic at 12 months.

    Conclusion: We found mainly narrower reference intervals compared with previously published studies. The reference intervals for each parameter varied according to the infants' age, demonstrating the necessity of age definitions when presenting infant reference intervals. The discrepancy with the WHO classification for anaemia at 12 months, despite favourable conditions in infancy, needs future investigation.

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  • 5. Lynøe, Niels
    et al.
    Elinder, Göran
    Hallberg, Boubou
    Rosén, Måns
    Sundgren, Pia
    Eriksson, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Rättsmedicin.
    Easier to see the speck in your critical peers' eyes than the log in your own? Response to Debelle et al.2018Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 103, nr 7, s. 714-Artikel i tidskrift (Refereegranskat)
  • 6.
    Namatovu, Fredinah
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Lindkvist, Marie
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Olsson, Cecilia
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för kostvetenskap.
    Ivarsson, Anneli
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Sandström, Olof
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. olof.sandstrom@pediatri.umu.se.
    Season and region as risk factors for celiac disease: a key to the aetiology?2016Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, s. 1114-1118Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several environmental factors are considered.

    Methods: A nationwide prospective cohort longitudinal study was conducted consisting of 1 912 204 children aged 0–14.9 years born in Sweden from 1991 to 2009. A total of 6569 children were diagnosed with biopsy-verified CD from 47 paediatric departments. Using Cox regression, we examined the association between CD diagnosis and season of birth, region of birth and year of birth.

    Results: Overall, CD risk was higher for children born during spring, summer and autumn as compared with children born during winter: adjusted HR for spring 1.08 (95% CI 1.01 to 1.16), summer 1.10 (95% CI 1.03 to 1.18) and autumn 1.10 (95% CI 1.02 to 1.18). Increased CD risk was highest if born in the south, followed by central Sweden when compared with children born in northern Sweden. Children diagnosed at <2 years had an increased CD risk if born in spring while those diagnosed at 2–14.9 years the risk was increased for summer and autumn births. The birth cohort of 1991–1996 had increased CD risk if born during spring, for the 1997–2002 birth cohort the risk increased for summer and autumn births, while for the birth cohort of 2003–2009 the risk was increased if born during autumn.

    Conclusions: Season of birth and region of birth are independently and jointly associated with increased risk of developing CD during the first 15 years of life. Seasonal variation in infectious load is the likely explanation.

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  • 7.
    Namatovu, Fredinah
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Strandh, Mattias
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för socialt arbete.
    Ivarsson, Anneli
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Nilsson, Karina
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Effect of childhood coeliac disease on ninth grade school performance: evidence from a population-based study2018Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 103, nr 2, s. 143-148Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Coeliac disease might affect school performance due to its effect on cognitive performance and related health consequences that might increase school absenteeism. The aim of this study was to investigate whether children with coeliac disease performed differently on completion of ninth grade in school compared with children without coeliac disease.

    Methods: Analysis was performed on a population of 445 669 children born in Sweden between 1991 and 1994 of whom 1767 were diagnosed with coeliac disease. School performance at ninth grade was the outcome and coeliac disease was the exposure. Other covariates included sex, Apgar score at 5 min, small for gestational age, year of birth, family type, parental education and income.

    Results: There was no association between coeliac disease and school performance at ninth grade (adjusted coefficient -2.4, 95% CI 5.1 to 0.4). A weak association was established between late coeliac diagnosis and higher grades, but this disappeared after adjusting for parent socioeconomic conditions. Being small for gestational age affected performance negatively (adjusted coefficient -6.9, 95% CI 8.0 to 5.7). Grade scores were significantly lower in children living with a single parent (adjusted coefficient -20.6, 95% CI 20.9 to 20.2), compared with those with married/cohabiting parents. A positive association was found between scores at ninth grade and parental education and income.

    Conclusion: Coeliac disease diagnosis during childhood is not associated with poor school performance at ninth grade.

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  • 8.
    Sandström, Olof
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Norström, Fredrik
    Umeå universitet, Medicinska fakulteten, Institutionen för epidemiologi och global hälsa.
    Carlsson, Annelie
    Department of Clinical Sciences, Paediatrics, Lund University, Lund, Sweden.
    Högberg, Lotta
    Department of Clinical and Experimental Medicine, Paediatrics, Linköping University, Linkoping, Östergötland, Sweden.
    van der Pals, Maria
    Department of Clinical Sciences, Paediatrics, Lund University, Lund, Sweden.
    Stenhammar, Lars
    Department of Clinical and Experimental Medicine, Paediatrics, Linköping University, Linkoping, Östergötland, Sweden.
    Webb, Charlotta
    Department of Clinical Sciences, Paediatrics, Lund University, Lund, Sweden.
    Ivarsson, Anneli
    Umeå universitet, Medicinska fakulteten, Institutionen för epidemiologi och global hälsa.
    Myléus, Anna
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Five-year follow-up of new cases after a coeliac disease mass screening2022Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 107, nr 6, s. 596-600Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease.

    METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the screening study (n=12 353) were linked to the National Swedish Childhood Coeliac Disease Register to find cases diagnosed in healthcare during the same period.

    RESULTS: In total, 230 (77%) came to the follow-up appointment, including 34 of 39 with potential coeliac disease. Of these, 11 (32%) had converted to coeliac disease. One new case was found in the National Swedish Childhood Coeliac Disease Register who received the diagnosis through routine screening in children with type 1 diabetes.

    CONCLUSIONS: There is a high risk of conversion to coeliac disease among those with potential disease. However, a negative screening test was associated with a very low risk for a clinical diagnosis within a follow-up period of 5 years.

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  • 9. Skovbjerg, S
    et al.
    Roos, K
    Holm, Stig
    Grahn Håkansson, Eva
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Nowrouzian, F
    Ivarsson, M
    Adlerberth, I
    Wold, AE
    Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media2009Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 94, nr 2, s. 92-98Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study shows that spray treatment with S sanguinis may be effective against SOM. The mechanism for the effect remains to be investigated.

  • 10.
    Späth, Cornelia
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap.
    Stoltz Sjöström, Elisabeth
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Domellöf, Magnus
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Effects Of Early Sodium And Fluid Intakes On Sodium Levels And Weight Change In Extremely Preterm Infants2014Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 99, nr Suppl 2, s. A38-A38, artikel-id 0-046Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Hypernatremia is common in extremely preterm infants but it is unclear to what extent it is affected by sodium (Na) and fluid intakes. It is assumed that infants normally lose 5–10% of birth weight during the first postnatal days.

    Aim: To explore associations between early intakes of Na and fluids and biochemical levels of Na as well as weight change during early postnatal life.

    Method: We investigated a population-based cohort of Swedish extremely preterm infants (<27 gestational weeks). Detailed data of Na intakes, biochemical levels of Na and anthropometric measurements were retrospectively obtained from hospital records. Data are expressed as mean±SD.

    Results: Preliminary analyses of 547 infants (gestational age 25.3 ± 1.1, birth weight 762 ± 170g) showed that highest Na levels occurred at day 3 of life (144.3 ± 6.2mmol/L) and were associated with Na intake during the first 2 days of life (R=+0.25), gestational age (R=-0.23) and birth weight (R=-0.18) (p < 0.001 for all).

    Of included infants 32% lost more than 10% of birth weight during the first 3 days. There was a strong correlation between fluid intake within the first two days of life and weight change between birth and day 3 (R=+0.56, p < 0.001). Among those (27%) who lost between 5–10% in weight, fluid intakes were on average 103 mL/kg/d.

    Conclusion: Early Na levels were significantly correlated with early Na intake, low gestational age as well as low birth weight. In order to avoid hypernatremia and excessive weight loss, fluid and Na intakes during the first 2 days need to be strictly regulated.

  • 11.
    Videholm, Samuel
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik. Unit of Research, Development, and Education, Östersund Hospital, Östersund, Sweden.
    Silfverdal, Sven-Arne
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Gustafsson, Per E.
    Umeå universitet, Medicinska fakulteten, Institutionen för epidemiologi och global hälsa.
    Socioeconomic circumstances, health-related behaviours and paediatric infections: a mediation analysis2024Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 109, nr 3, s. 195-200Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: To examine how the effect of disadvantaged socioeconomic circumstances on the risk of paediatric infections is mediated by pregnancy smoking, excess weight during pregnancy and breast feeding in children under 5 years of age.

    Design: A population-level, retrospective cohort study. The Swedish Medical Birth Register was combined with the National Patient Register, the longitudinal integration database for health insurance and labour market studies, the Cause of Death Register and a local register held by the Child Health Care Unit in Uppsala Region.

    Setting: Uppsala Region, Sweden.

    Patients: 63 216 term and post-term singletons born to women who resided in Uppsala Region, Sweden between 1997 and 2015.

    Main outcome measures: Number of hospital admissions for infectious diseases. Secondary outcomes were the number of hospitalisations for respiratory and enteric infections, respectively.

    Results: The effect of disadvantaged socioeconomic circumstances, that is, low maternal education on the overall risk of paediatric infections was mediated to a considerable (33%-64%) proportion by pregnancy smoking, excess weight during pregnancy and breast feeding.

    Conclusions: Pregnancy smoking, excess weight during pregnancy and breast feeding mediate a considerable proportion of the association between deprived socioeconomic circumstances and paediatric infectious diseases. Therefore, inequalities in paediatric infectious diseases may be reduced by public health policies addressing these health-related behaviours.

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  • 12.
    Videholm, Samuel
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik. Unit of Research, Development, and Education, Östersund Hospital, Östersund, Sweden.
    Silfverdal, Sven-Arne
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Reniers, Georges
    Maternal weight and infections in early childhood: a cohort study2019Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 104, nr 1, s. 58-63Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective The aim of this study was to examine this association between maternal weight during pregnancy and the incidence of hospitalisations for infectious diseases during early childhood. Design A population-based cohort study. Setting A national cohort was created by combining data from the Swedish Medical Birth Register, the National Inpatient Register, the Cause of Death Register, the Total Population Register and the Longitudinal integration database for health insurance and labour market studies. Patients 693 007 children born in Sweden between 1998 and 2006. Main outcome measures Number of hospitalisations for infectious diseases during the first 5 years of life, overall and for categories of infectious diseases (lower respiratory, enteric, upper respiratory, genitourinary, perinatal, skin and soft tissue, neurological and eye, digestive tract, bloodstream and other infections). Results Overweight (body mass index (BMI) 25.0-29.9) and obesity (BMI >= 30) during pregnancy were associated with a higher overall incidence of hospitalisations for infectious diseases, adjusted incidence rate ratio (IRR) 1.05 (95% CI 1.03 to 1.06) and adjusted IRR 1.18 (95% CI 1.16 to 1.21). Overweight and obesity during pregnancy were strongly associated with perinatal infections, adjusted IRR 1.34 (95% CI 1.25 to 1.44) and adjusted IRR 1.72 (95% CI 1.57 to 1.88). In contrast, we found no association between maternal weight during pregnancy and infections of skin and soft tissue, the nervous system, the digestive tract or the bloodstream. Conclusions We observed an association between overweight and obesity during pregnancy, and hospitalisations for infectious diseases during early childhood.

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