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  • 1.
    Forsén Mantilla, Emma
    et al.
    Department of Medical Epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden.
    Clinton, David
    Department of Medical Epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden.
    Monell, Elin
    Department of Medical Epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden.
    Levallius, Johanna
    Department of Medical Epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden.
    Birgegård, Andreas
    Department of Medical Epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden.
    Impulsivity and compulsivity as parallel mediators of emotion dysregulation in eating-related addictive-like behaviors, alcohol use, and compulsive exercise2022Inngår i: Brain and Behavior, E-ISSN 2162-3279, Vol. 12, nr 1, artikkel-id e2458Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    INTRODUCTION: Transdiagnostically relevant psychological traits associated with psychiatric disorders are increasingly being researched, notably in substance use and addictive behaviors. We investigated whether emotion dysregulation mediated by impulsivity and/or compulsivity could explain variance in binge eating, food addiction, self-starvation, and compulsive exercise, as well as alcohol use (addictive-like behaviors relevant to the obesity and eating disorder fields).

    METHOD: A general population sample of adults (N = 500, mean age = 32.5 years), females (n = 376) and males (n = 124), completed the Difficulties in Emotion Regulation Scale-16, the Trait Rash Impulsivity Scale, the Obsessive-Compulsive Inventory-Revised, the Eating Disorders Examination Questionnaire, the Self-Starvation Scale, the Exercise Dependence Scale, the Yale Food Addiction Scale, and the Alcohol Use Disorders Identification Test online. Besides gender comparisons and intercorrelations between measures, we used predefined multiple mediation models with emotion dysregulation as independent variable, impulsivity and compulsivity as parallel mediators, to investigate whether these factors contributed explanatory power to each addictive-like behavior as outcome, also using age and body mass index as covariates.

    RESULTS: Females scored higher than males on emotion dysregulation and the eating-related addictive-like behaviors food addiction, self-starvation, and binge eating. Intercorrelations between measures showed that emotion dysregulation and compulsivity were associated with all outcome variables, impulsivity with all except compulsive exercise, and the eating-related behaviors intercorrelated strongly. Mediation models showed full or partial mediation of emotion dysregulation for all behaviors, especially via compulsivity, suggesting a behavior-specific pattern. Mediation models were not affected by age or gender.

    DISCUSSION: Addictive-like behaviors seemed to be maintained by trait levels of emotion dysregulation, albeit channeled via trait levels of compulsivity and/or impulsivity. The role of emotion dysregulation may help us to understand why addictive-like behaviors can be difficult to change in both clinical and nonclinical groups, and may be informative for treatment-planning in patients where these behaviors are present. Our findings support adopting a more dimensional approach to psychiatric classification by focusing psychological facets such as those studied.

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  • 2.
    Forsén Mantilla, Emma
    et al.
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Levallius, Johanna
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Monell, Elin
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Birgegård, Andreas
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Exercise caution: Questions to ask adolescents who may exercise too hard2018Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 15, nr 4, artikkel-id 797Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    When the primary goal of exercise is to compensate for food intake and to alter body shape and weight, it is considered compulsive and may be harmful. Compulsive exercise (CE) is important in the pathogenesis of eating disorders (EDs). Many healthy adolescents engage in CE too, and this may indicate a risk for EDs. Our aim was to learn more about ED risk factors tied to CE and to try to isolate questions to ask in order to probe for high ED risk in adolescents engaging in CE. Using two well-established instruments (the Structural Analysis of Social Behavior and the Eating Disorders Examination Questionnaire), we studied associations between ED variables and CE in healthy adolescent boys and girls. We examined gender-specific items to generate the best possible fit for each gender. Individuals with CE displayed significantly greater ED pathology and more self-criticism, and this pattern was stronger in girls than in boys. Risk factors for ED among individuals with CE differed slightly for boys and girls. We put forward a set of gender-specific questions that may be helpful when probing for ED risk among adolescents engaging in CE.

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  • 3.
    Högdahl, Louise
    et al.
    Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatric Research, Stockholm, Sweden.
    Levallius, Johanna
    Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatric Research, Stockholm, Sweden.
    Björck, Caroline
    Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatric Research, Stockholm, Sweden.
    Norring, Claes
    Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatric Research, Stockholm, Sweden.
    Birgegård, Andreas
    Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatric Research, Stockholm, Sweden.
    Personality predicts drop-out from therapist-guided internet-based cognitive behavioural therapy for eating disorders: Results from a randomized controlled trial2016Inngår i: Internet Interventions, ISSN 2214-7829, Vol. 5, s. 44-50Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Internet-based guided self-help cognitive behavioural therapy (ICBT) seems a promising way of delivering eating disorder treatment. However, treatment drop-out is a common problem and little is known about the correlates, especially in clinical settings. The study aimed to explore prediction of drop-out in the context of a randomized controlled trial within specialized eating disorder care in terms of eating disorder symptomatology, personality traits, comorbidity, and demographic characteristics. 109 outpatients diagnosed with bulimia nervosa or similar eating disorder were randomized to two types of ICBT. Participants were assessed with several clinical- and self-ratings. The average drop-out rate was 36%. Drop-out was predicted by lower scores in the personality traits Dutifulness and Assertiveness as measured by the NEO Personality Inventory Revised, and by higher scores in Self-affirm as measured by the Structural Analysis of Social Behaviour. Drop-out was also predicted by therapist factors: one therapist had significantly more drop-outs (82%) than the other three (M = 30%). Theoretical and clinical implications of the impact of the predictors are discussed.

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  • 4.
    Levallius, Johanna
    et al.
    Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center for Eating Disorders Innovation, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Clinton, David
    Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center for Eating Disorders Innovation, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Institute for Eating Disorders, Kruses gate 8, Oslo, Norway.
    Högdahl, Louise
    Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Norring, Claes
    Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Personality as predictor of outcome in internet-based treatment of bulimic eating disorders2020Inngår i: Eating Behaviors, ISSN 1471-0153, E-ISSN 1873-7358, Vol. 36, artikkel-id 101360Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Internet-based cognitive behavioral therapy (ICBT) for bulimic eating disorders has demonstrated clinical utility and cost efficiency, but is associated with low patient preference, low credibility, sizeable dropout and only moderate symptom reduction. To improve outcome it is imperative to learn more about who might benefit from internet-based interventions. To do this, the current study investigated the Five Factor Model of personality as predictor of outcome in patients with full or sub-threshold bulimia nervosa (n = 109). Patients in a randomized controlled trial of ICBT were assessed prior to and at the end of treatment. Patients showed significant symptom reduction over time (Cohen's d = 1.0, p < .001). Remission as well as overall symptom reduction was positively predicted by Openness to Experience and Conscientiousness. Binge eating cessation specifically, was positively predicted by Extraversion. The study supports the use of personality assessment for patient selection and outcome optimization in internet-based treatment of bulimic eating disorders.

  • 5.
    Levallius, Johanna
    et al.
    Department of Clinical Neuroscience, Resource Center for Eating Disorders, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Resource Center for Eating Disorders, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Collin, Christina
    Department of Clinical Neuroscience, Resource Center for Eating Disorders, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Resource Center for Eating Disorders, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Birgegård, Andreas
    Department of Clinical Neuroscience, Resource Center for Eating Disorders, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Resource Center for Eating Disorders, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Now you see it, now you don't: compulsive exercise in adolescents with an eating disorder2017Inngår i: Journal of eating disorders, ISSN 2050-2974, Vol. 5, artikkel-id 9Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Compulsive exercise (CE) has been proposed as significant in the etiology, development and maintenance of eating disorders (EDs), resulting in more severe and enduring pathology. However, few studies have investigated CE longitudinally in adolescents with EDs. We aimed to test if adolescents show the same associations between CE and other clinical variables as previous research has found in adults.

    METHODS: Three thousand one hundred sixteen girls and 139 boys from a clinical ED database were investigated regarding prevalence and frequency of CE and its relation to psychiatric symptoms, associated features and outcome. Denial of illness is common among adolescents and was therefore adjusted for.

    RESULTS: Adjusted CE prevalence in girls was 44%, and CE was most prevalent in bulimia nervosa. As previously found in adults, those with CE scored significantly higher than non-CE on total ED severity, level of restriction and negative perfectionism. However, there were only minor differences between CE and non-CE patients on emotional distress, hyperactivity, suicidality and self-esteem. Among boys, adjusted CE prevalence was 38%, and CE boys scored significantly higher than non-CE on total ED severity. Initial CE did not influence 1-year outcome, although cessation of CE was associated with remission.

    CONCLUSIONS: CE is a common clinical feature in adolescents with EDs and cessation is associated with remission. When controlling for denial of illness, CE had less detrimental impact than predicted. We recommend controlling for denial in studies on ED adolescents and further exploration of classification and treatment implications of CE.

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  • 6.
    Levallius, Johanna
    et al.
    Department of Medical Epidemiology and Biostatistics,Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden.
    Monell, Elin
    Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Birgegård, Andreas
    Department of Medical Epidemiology and Biostatistics, Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden.
    Clinton, David
    Department of Medical Epidemiology and Biostatistics, Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden; Institute for Eating Disorders, Oslo, Norway.
    Forsén Mantilla, Emma
    Department of Medical Epidemiology and Biostatistics, Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Binge eating and addictive-like behaviours in males and females2022Inngår i: Psychological Reports, ISSN 0033-2941, E-ISSN 1558-691X, Vol. 125, nr 1, s. 148-166Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    INTRODUCTION: Binge eating is a common behaviour that is strongly linked to both obesity and eating disorder. There is evidence that binge eating commonly co-occurs with other problematic and addictive-like behaviours; however, this has not been explored systematically. The present study aimed to examine the relationship between binge eating, body weight, disordered eating behaviours and associated addictive-like behaviours, with particular attention paid to gender differences.

    METHOD: A community sample (N = 500; 75% female, Mage = 32.5 years) reported disordered eating behaviours (i.e. binge eating, purging, restriction of eating, compulsive exercise), body mass index (BMI), food addiction, starvation addiction, exercise dependence, tobacco use and alcohol consumption.

    RESULTS: 42% of females and 21% of males reported binge eating during the past four weeks. Binge eating was significantly associated with all investigated behaviours in females, and with purging, compulsive exercise and overweight/obesity in males. Controlling for BMI, self-starvation predicted binge eating in males (OR = 1.07), while food addiction (OR = 1.73) and alcohol dependence (OR = 1.11) predicted binge eating in females.

    CONCLUSIONS: The multiple associations between binge eating and addictive-like behaviors supports broad screening and generalized prevention efforts. Prevention efforts should reflect gender differences.

  • 7.
    Levallius, Johanna
    et al.
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
    Roberts, Brent W
    Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
    Clinton, David
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
    Norring, Claes
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
    Take charge: Personality as predictor of recovery from eating disorder2016Inngår i: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 246, s. 447-452Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Many treatments for eating disorders (ED) have demonstrated success. However, not all patients respond the same to interventions nor achieve full recovery, and obvious candidates like ED diagnosis and symptoms have generally failed to explain this variability. The current study investigated the predictive utility of personality for outcome in ED treatment. One hundred and thirty adult patients with bulimia nervosa or eating disorder not otherwise specified enrolled in an intensive multimodal treatment for 16 weeks. Personality was assessed with the NEO Personality Inventory Revised (NEO PI-R). Outcome was defined as recovered versus still ill and also as symptom score at termination with the Eating Disorder Inventory-2 (EDI-2). Personality significantly predicted both recovery (70% of patients) and symptom improvement. Patients who recovered reported significantly higher levels of Extraversion at baseline than the still ill, and Assertiveness emerged as the personality trait best predicting variance in outcome. This study indicates that personality might hold promise as predictor of recovery after treatment for ED. Future research might investigate if adding interventions to address personality features improves outcome for ED patients.

  • 8.
    Levallius, Johanna
    et al.
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Rydén, Göran
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Norring, Claes
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Maturation in patients with borderline personality disorder2015Inngår i: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 228, nr 3, s. 950-952Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Patients with borderline personality disorder have a characteristic and extreme personality associated with psychopathology. The aim was to investigate personality change in relation to suicidality following treatment. 21 patients were assessed before and after psychotherapy on personality (NEO PI-R) and suicidality (SUAS). At follow-up, Neuroticism and Conscientiousness normalized along with six lower-order facets; Depression, Impulsiveness, Competence, Achievement Striving, Self-Discipline and Deliberation. Thirteen patients showed a positive personality development paralleled by a lesser degree of suicidality.

  • 9.
    Monell, Elin
    et al.
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Levallius, Johanna
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Forsén Mantilla, Emma
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Birgegård, Andreas
    Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
    Running on empty: a nationwide large-scale examination of compulsive exercise in eating disorders2018Inngår i: Journal of eating disorders, ISSN 2050-2974, Vol. 6, artikkel-id 11Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Compulsive exercise (CE) has been the neglected "Cinderella" among eating disorder (ED) symptoms, even though it seems to impact severity, treatment and outcome. This prompted a large-scale and systematic examination of the impact of CE in a representative ED sample.

    METHODS: CE was examined in over 9000 female and male patients from a clinical ED database (covering out-patient, day and/or residential treatment) with respect to prevalence, ED diagnosis, ED symptoms, clinical features, patient characteristics, and outcome at 1-year follow-up. Relationships between changes in CE behavior and remission were also examined.

    RESULTS: CE was a transdiagnostic symptom, present in nearly half of all patients (48%). It was associated with greater overall ED pathology, particularly dietary restraint, and negative perfectionism. Initial CE did not impact remission rate, but patients continuing or starting CE during treatment had considerably lower remission rates compared to patients who never engaged in, or ceased with, CE. Results were comparable for females and males.

    CONCLUSIONS: At baseline, there were few differences between patients with and without CE, except a somewhat higher symptom load for patients with CE, and CE did not predict ED outcome. However, how CE developed during treatment to 1-year follow-up considerably impacted remission rates. We strongly recommend CE to be systematically assessed, addressed, and continuously evaluated in all ED patients seeking treatment.

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  • 10.
    Reas, Deborah Lynn
    et al.
    Division of Mental Health and Addiction, Regional Department for Eating Disorders, Oslo University Hospital, Oslo, Norway; Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.
    Isomaa, Rasmus
    Department of Social Services and Health Care, Fredrikakliniken, Jakobstad, Finland; Faculty of Education and Welfare Studies,Abo Akademi University, Vasa, Finland.
    Solhaug Gulliksen, Kjersti
    The Norwegian Psychological Association, Oslo, Norway; The Institute of Eating Disorders, Hunger House, Oslo, Norway .
    Levallius, Johanna
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Clinicians as a critical link: Understanding health professionals' beliefs and attitudes toward anorexia nervosa, bulimia nervosa, and binge eating disorder2021Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 62, nr 6, s. 775-779Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Understanding the perspectives of health professionals remains an understudied issue, yet may help bridge research-practice gaps and pinpoint important areas for education, training, and research. This study investigated attitudes toward anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) among Nordic health professionals specialized within the eating disorder (ED) field. Participants (n = 144) completed a modified ED-version of the Illness Perception Questionnaire which assessed attitudes and beliefs toward perceived symptom controllability, severity, treatment effectiveness, and views on the prognosis of AN, BN, and BED. Personal enjoyment and level of comfort working with AN, BN, and BED were also assessed. The majority agreed or strongly agreed that patients with AN, BN, and BED were not responsible for their illness, and viewed the illnesses as psychological rather than medical in etiology. AN was viewed as the most severe and enduring, followed by BN, then BED. Treatment for BN was viewed as being more highly effective than treatments for either AN or BED. Professionals rated significantly less enjoyment and less confidence working with BED. To conclude, both commonalities and differences in attitudes toward AN, BN and BED were found in terms of perceived symptom controllability, views on severity, treatment effectiveness, and anticipated prognosis. In particular, findings emphasized the need for additional training in the management of BED among Nordic healthcare professionals.

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