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  • 1. Analitis, Antonis
    et al.
    De' Donato, Francesca
    Scortichini, Matteo
    Lanki, Timo
    Basagana, Xavier
    Ballester, Ferran
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Paldy, Anna
    Pascal, Mathilde
    Gasparrini, Antonio
    Michelozzi, Paola
    Katsouyanni, Klea
    Synergistic Effects of Ambient Temperature and Air Pollution on Health in Europe: Results from the PHASE Project2018Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 15, nr 9, s. 1-11, artikkel-id E1856Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We studied the potential synergy between air pollution and meteorology and their impact on mortality in nine European cities with data from 2004 to 2010. We used daily series of Apparent Temperature (AT), measurements of particulate matter (PM10), ozone (O₃), and nitrogen dioxide (NO₂) and total non-accidental, cardiovascular, and respiratory deaths. We applied Poisson regression for city-specific analysis and random effects meta-analysis to combine city-specific results, separately for the warm and cold seasons. In the warm season, the percentage increase in all deaths from natural causes per °C increase in AT tended to be greater during high ozone days, although this was only significant for all ages when all causes were considered. On low ozone days, the increase in the total daily number of deaths was 1.84% (95% CI 0.87, 2.82), whilst it was 2.20% (95% CI 1.28, 3.13) in the high ozone days per 1 °C increase in AT. Interaction with PM10 was significant for cardiovascular (CVD) causes of death for all ages (2.24% on low PM10 days (95% CI 1.01, 3.47) whilst it is 2.63% (95% CI 1.57, 3.71) on high PM10 days) and for ages 75+. In days with heat waves, no consistent pattern of interaction was observed. For the cold period, no evidence for synergy was found. In conclusion, some evidence of interactive effects between hot temperature and the levels of ozone and PM10 was found, but no consistent synergy could be identified during the cold season.

    Fulltekst (pdf)
    fulltext
  • 2.
    Andersson, Louise
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Oudin Åström, Daniel
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Pettersson-Strömbäck, Anita
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Med värme ihågkommen2012Rapport (Annet vitenskapelig)
    Abstract [sv]

    Syftet med detta projekt har varit att med hjälp av en intervjustudie och kunskapsgenomgång redovisahur utomhusmiljö, gemensamhetslokaler och bostäder kan utformas för att minska risken för att äldreoch personer med nedsatt funktionsförmåga blir medtagna eller dör i förtid under värmeböljor. Måletär att öka medvetenheten och intresset för anpassning av miljö och byggnader hos personer ansvarigaför samhällsplanering, bostadsbestånd, trygghets-, vård- och omsorgsboenden.

    Städer är normalt varmare och mindre blåsiga än det omgivande landskapet. Städernas ”varmareklimat” beror främst på den större värmelagring som kan ske i byggnader, gator, trottoarer mm,begränsat med vegetation som kan skugga och avge fukt samt aktiviteter som trafik och eldning vilketgenererar värme. Under värmeböljor ökar dödligheten mer i städer. Att leva ensam, vara sängbundenoch bo på översta våningen har visats vara riskfaktorer.

    Åtgärderna för att minska stadens värmeö och värmeböljornas effekter på människor brukar iblanddelas in i ”mjuka åtgärder” (information, varningssystem för värmeböljor, insatser för känsligagrupper), ”gröna åtgärder” (göra staden till en grönare miljö) och ”tekniska åtgärder” (skuggandekonstruktioner, modifiering av väggar, kylning/luftkonditionering inomhus etc.), vilka kompletterarvarandra. I vissa länder, bl. a. England, ska äldreboenden ha ett samlingsrum som kan hållas svaltäven under värmeböljor, men det är oklart vilken juridisk status som bestämmelserna har.

    Intervjustudien syftade till att belysa hur problemen uppfattas av personal inom äldreomsorgen iSverige. Som datainsamlingsmetod genomfördes 20 semistrukturerade intervjuer medomvårdnadspersonal i Botkyrka kommun under oktober 2011. Urvalet baserades påtillgänglighetsprincipen. Innehållsanalyser gjordes på transkriberad intervjudata och kategorier ochunderkategorier skapades utifrån återkommande teman som återfanns i texten. Slutsatserna frånstudien pekar på att de utbildnings- och informationsinsatser angående värmeböljors effekter påkänsliga grupper som riktas till personal inom äldreomsorgen borde intensifieras, samt attpersonalens kunskap om verksamheten och vårdtagarnas behov borde tas tillvara redan iplaneringsstadiet för äldreboenden.

    Fulltekst (pdf)
    fulltext
  • 3. Barnett, A. G.
    et al.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Commentary: What measure of temperature is the best predictor of mortality?2012Inngår i: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 118, s. 149-151Artikkel i tidsskrift (Annet vitenskapelig)
  • 4.
    Béguin, Andreas
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Hales, Simon
    University of Otago, Wellington, New Zealand.
    Rocklöv, Joacim
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Louis, Valérie R
    Institute for Public Health, Heidelberg University Hospital, Heidelberg, Germany.
    Sauerborn, Rainer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    The opposing effects of climate change and socio-economic development on the global distribution of malaria2011Inngår i: Global Environmental Change, ISSN 0959-3780, E-ISSN 1872-9495, Vol. 21, nr 4, s. 1209-1214Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The current global geographic distribution of malaria results from a complex interaction between climatic and non-climatic factors. Over the past century, socio-economic development and public health measures have contributed to a marked contraction in the distribution of malaria. Previous assessments of the potential impact of global changes on malaria have not quantified the effects of non-climate factors. In this paper, we describe an empirical model of the past, present and future-potential geographic distribution of malaria which incorporates both the effects of climate change and of socio-economic development. A logistic regression model using temperature, precipitation and gross domestic product per capita (GDPpc) identifies the recent global geographic distribution of malaria with high accuracy (sensitivity 85% and specificity 95%). Empirically, climate factors have a substantial effect on malaria transmission in countries where GDPpc is currently less than US$20,000. Using projections of future climate, GDPpc and population consistent with the IPCC A1B scenario, we estimate the potential future population living in areas where malaria can be transmitted in 2030 and 2050. In 2050, the projected population at risk is approximately 5.2 billion when considering climatic effects only, 1.95 billion when considering the combined effects of GDP and climate, and 1.74 billion when considering GDP effects only. Under the A1B scenario, we project that climate change has much weaker effects on malaria than GDPpc increase. This outcome is, however, dependent on optimistic estimates of continued socioeconomic development. Even then, climate change has important effects on the projected distribution of malaria, leading to an increase of over 200 million in the projected population at risk.

  • 5. Chen, Gongbo
    et al.
    Guo, Yuming
    Yue, Xu
    Tong, Shilu
    Gasparrini, Antonio
    Bell, Michelle L.
    Armstrong, Ben
    Schwartz, Joel
    Jaakkola, Jouni J. K.
    Zanobetti, Antonella
    Lavigne, Eric
    Nascimento Saldiva, Paulo Hilario
    Kan, Haidong
    Royé, Dominic
    Milojevic, Ai
    Overcenco, Ala
    Urban, Aleš
    Schneider, Alexandra
    Entezari, Alireza
    Vicedo-Cabrera, Ana Maria
    Zeka, Ariana
    Tobias, Aurelio
    Nunes, Baltazar
    Alahmad, Barrak
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Pan, Shih-Chun
    Íñiguez, Carmen
    Ameling, Caroline
    De la Cruz Valencia, César
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Houthuijs, Danny
    Van Dung, Do
    Samoli, Evangelia
    Mayvaneh, Fatemeh
    Sera, Francesco
    Carrasco-Escobar, Gabriel
    Lei, Yadong
    Orru, Hans
    Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia..
    Kim, Ho
    Holobaca, Iulian-Horia
    Kyselý, Jan
    Teixeira, João Paulo
    Madureira, Joana
    Katsouyanni, Klea
    Hurtado-Díaz, Magali
    Maasikmets, Marek
    Ragettli, Martina S.
    Hashizume, Masahiro
    Stafoggia, Massimo
    Pascal, Mathilde
    Scortichini, Matteo
    de Sousa Zanotti Stagliorio Coêlho, Micheline
    Valdés Ortega, Nicolás
    Ryti, Niilo R. I.
    Scovronick, Noah
    Matus, Patricia
    Goodman, Patrick
    Garland, Rebecca M.
    Abrutzky, Rosana
    Garcia, Samuel Osorio
    Rao, Shilpa
    Fratianni, Simona
    Dang, Tran Ngoc
    Colistro, Valentina
    Huber, Veronika
    Lee, Whanhee
    Seposo, Xerxes
    Honda, Yasushi
    Guo, Yue Leon
    Ye, Tingting
    Yu, Wenhua
    Abramson, Michael J.
    Samet, Jonathan M.
    Li, Shanshan
    Mortality risk attributable to wildfire-related PM2·5 pollution: a global time series study in 749 locations2021Inngår i: The Lancet Planetary Health, E-ISSN 2542-5196, Vol. 5, nr 9, s. e579-e587Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5 and mortality across various regions of the world.

    METHODS: For this time series study, data on daily counts of deaths for all causes, cardiovascular causes, and respiratory causes were collected from 749 cities in 43 countries and regions during 2000-16. Daily concentrations of wildfire-related PM2·5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0·25° × 0·25° resolution. The association between wildfire-related PM2·5 exposure and mortality was examined using a quasi-Poisson time series model in each city considering both the current-day and lag effects, and the effect estimates were then pooled using a random-effects meta-analysis. Based on these pooled effect estimates, the population attributable fraction and relative risk (RR) of annual mortality due to acute wildfire-related PM2·5 exposure was calculated.

    FINDINGS: 65·6 million all-cause deaths, 15·1 million cardiovascular deaths, and 6·8 million respiratory deaths were included in our analyses. The pooled RRs of mortality associated with each 10 μg/m3 increase in the 3-day moving average (lag 0-2 days) of wildfire-related PM2·5 exposure were 1·019 (95% CI 1·016-1·022) for all-cause mortality, 1·017 (1·012-1·021) for cardiovascular mortality, and 1·019 (1·013-1·025) for respiratory mortality. Overall, 0·62% (95% CI 0·48-0·75) of all-cause deaths, 0·55% (0·43-0·67) of cardiovascular deaths, and 0·64% (0·50-0·78) of respiratory deaths were annually attributable to the acute impacts of wildfire-related PM2·5 exposure during the study period.

    INTERPRETATION: Short-term exposure to wildfire-related PM2·5 was associated with increased risk of mortality. Urgent action is needed to reduce health risks from the increasing wildfires.

    Fulltekst (pdf)
    fulltext
  • 6.
    Chen, Kai
    et al.
    Department of Environmental Health Sciences, Yale School of Public Health, CT, New Haven, United States.
    Breitner, Susanne
    Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.
    Wolf, Kathrin
    Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany.
    Stafoggia, Massimo
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
    Sera, Francesco
    Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom; Department of Statistics, Computer Science and Applications “G. Parenti”, University of Florence, Florence, Italy.
    Vicedo-Cabrera, Ana M.
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Oeschger Center for Climate Change Research, University of Bern, Bern, Switzerland.
    Guo, Yuming
    Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, VIC, Melbourne, Australia.
    Tong, Shilu
    Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China; School of Public Health and Social Work, Queensland University of Technology, QLD, Brisbane, Australia; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
    Lavigne, Eric
    Air Health Science Division, Health Canada, ON, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, ON, Ottawa, Canada.
    Matus, Patricia
    Department of Public Health, Universidad de los Andes, Santiago, Chile.
    Valdés, Nicolás
    Faculty of Nursing and Midwifery, Universidad de los Andes, Santiago, Chile.
    Kan, Haidong
    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai, China.
    Jaakkola, Jouni J. K.
    Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Finnish Meteorological Institute, Helsinki, Finland.
    Ryti, Niilo R. I.
    Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
    Huber, Veronika
    Department of Physical, Chemical and Natural Systems, Universidad Pablo de Olavide, Seville, Spain; Potsdam Institute for Climate Impact Research, Potsdam, Germany.
    Scortichini, Matteo
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
    Hashizume, Masahiro
    Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Honda, Yasushi
    Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
    Nunes, Baltazar
    Department of Epidemiology, Instituto Nacional de Saúde Dr Ricardo Jorge, Lisbon, Portugal; Centro de Investigação em Saúde Pública, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa, Lisbon, Portugal.
    Madureira, Joana
    Department of Enviromental Health, Instituto Nacional de Saúde Dr Ricardo Jorge, Porto, Portugal; EPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
    Holobâcă, Iulian Horia
    Faculty of Geography, Babes-Bolay University, Cluj-Napoca, Romania.
    Fratianni, Simona
    Department of Earth Sciences, University of Torino, Turin, Italy.
    Kim, Ho
    Graduate School of Public Health, Seoul National University, Seoul, South Korea.
    Lee, Whanhee
    Graduate School of Public Health, Seoul National University, Seoul, South Korea.
    Tobias, Aurelio
    Institute of Environmental Assessment and Water Research, Spanish Council for Scientific Research, Barcelona, Spain; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
    Íñiguez, Carmen
    Department of Statistics and Computational Research, University of Valencia, Valencia, Spain; , Ciberesp, Madrid, Spain.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Ragettli, Martina S.
    Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
    Guo, Yue-Liang Leon
    Environmental and Occupational Medicine, National Taiwan University and NTU Hospital, Taipei, Taiwan; National Institute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan.
    Chen, Bing-Yu
    National Institute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan.
    Li, Shanshan
    Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, VIC, Melbourne, Australia.
    Milojevic, Ai
    Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Zanobetti, Antonella
    Department of Environmental Health, Harvard T H Chan School of Public Health, MA, Boston, United States.
    Schwartz, Joel
    Department of Environmental Health, Harvard T H Chan School of Public Health, MA, Boston, United States.
    Bell, Michelle L.
    School of the Environment, Yale University, CT, New Haven, United States.
    Gasparrini, Antonio
    Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre on Climate Change and Planetary Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Schneider, Alexandra
    Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany.
    Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities2021Inngår i: The Lancet Planetary Health, E-ISSN 2542-5196, Vol. 5, nr 4, s. e191-e199Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between ambient CO and daily mortality, even at levels well below current air quality guidelines. Further studies are warranted to disentangle its independent effect from other traffic-related pollutants. Funding: EU Horizon 2020, UK Medical Research Council, and Natural Environment Research Council.

    Fulltekst (pdf)
    fulltext
  • 7. Choi, Hayon Michelle
    et al.
    Lee, Whanhee
    Roye, Dominic
    Heo, Seulkee
    Urban, Aleš
    Entezari, Alireza
    Vicedo-Cabrera, Ana Maria
    Zanobetti, Antonella
    Gasparrini, Antonio
    Analitis, Antonis
    Tobias, Aurelio
    Armstrong, Ben
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Íñiguez, Carmen
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Indermitte, Ene
    Lavigne, Eric
    Mayvaneh, Fatemeh
    Acquaotta, Fiorella
    Sera, Francesco
    Orru, Hans
    Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia..
    Kim, Ho
    Kyselý, Jan
    Madueira, Joana
    Schwartz, Joel
    Jaakkola, Jouni J. K.
    Katsouyanni, Klea
    Diaz, Magali Hurtado
    Ragettli, Martina S.
    Pascal, Mathilde
    Ryti, Niilo
    Scovronick, Noah
    Osorio, Samuel
    Tong, Shilu
    Seposo, Xerxes
    Guo, Yue Leon
    Guo, Yuming
    Bell, Michelle L.
    Effect modification of greenness on the association between heat and mortality: A multi-city multi-country study2022Inngår i: EBioMedicine, E-ISSN 2352-3964, Vol. 84, artikkel-id 104251Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Identifying how greenspace impacts the temperature-mortality relationship in urban environments is crucial, especially given climate change and rapid urbanization. However, the effect modification of greenspace on heat-related mortality has been typically focused on a localized area or single country. This study examined the heat-mortality relationship among different greenspace levels in a global setting.

    METHODS: We collected daily ambient temperature and mortality data for 452 locations in 24 countries and used Enhanced Vegetation Index (EVI) as the greenspace measurement. We used distributed lag non-linear model to estimate the heat-mortality relationship in each city and the estimates were pooled adjusting for city-specific average temperature, city-specific temperature range, city-specific population density, and gross domestic product (GDP). The effect modification of greenspace was evaluated by comparing the heat-related mortality risk for different greenspace groups (low, medium, and high), which were divided into terciles among 452 locations.

    FINDINGS: Cities with high greenspace value had the lowest heat-mortality relative risk of 1·19 (95% CI: 1·13, 1·25), while the heat-related relative risk was 1·46 (95% CI: 1·31, 1·62) for cities with low greenspace when comparing the 99th temperature and the minimum mortality temperature. A 20% increase of greenspace is associated with a 9·02% (95% CI: 8·88, 9·16) decrease in the heat-related attributable fraction, and if this association is causal (which is not within the scope of this study to assess), such a reduction could save approximately 933 excess deaths per year in 24 countries.

    INTERPRETATION: Our findings can inform communities on the potential health benefits of greenspaces in the urban environment and mitigation measures regarding the impacts of climate change.

    FUNDING: This publication was developed under Assistance Agreement No. RD83587101 awarded by the U.S. Environmental Protection Agency to Yale University. It has not been formally reviewed by EPA. The views expressed in this document are solely those of the authors and do not necessarily reflect those of the Agency. EPA does not endorse any products or commercial services mentioned in this publication. Research reported in this publication was also supported by the National Institute on Minority Health and Health Disparities of the National Institutes of Health under Award Number R01MD012769. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Also, this work has been supported by the National Research Foundation of Korea (2021R1A6A3A03038675), Medical Research Council-UK (MR/V034162/1 and MR/R013349/1), Natural Environment Research Council UK (Grant ID: NE/R009384/1), Academy of Finland (Grant ID: 310372), European Union's Horizon 2020 Project Exhaustion (Grant ID: 820655 and 874990), Czech Science Foundation (22-24920S), Emory University's NIEHS-funded HERCULES Center (Grant ID: P30ES019776), and Grant CEX2018-000794-S funded by MCIN/AEI/ 10.13039/501100011033 The funders had no role in the design, data collection, analysis, interpretation of results, manuscript writing, or decision to publication.

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  • 8.
    de Bont, Jeroen
    et al.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Pickford, Regina
    Institute of Epidemiology (EPI), Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Neuherberg, Germany.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Colomar, Fabian
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Dimakopoulou, Konstantina
    Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    de Hoogh, Kees
    Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
    Ibi, Dorina
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
    Katsouyanni, Klea
    Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; MRC Centre for Environment and Health, Environmental Research Group, Imperial College London, United Kingdom; NIHR HPRU in Environmental Exposures and Health, Imperial College London, London, United Kingdom.
    Melén, Erik
    Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
    Nobile, Federica
    Department of Epidemiology, Lazio Region Health Service /ASL Roma 1, Rome, Italy.
    Pershagen, Göran
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Persson, Åsa
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Samoli, Evangelia
    Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    Stafoggia, Massimo
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service /ASL Roma 1, Rome, Italy.
    Tonne, Cathryn
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Vlaanderen, Jelle
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
    Wolf, Kathrin
    Institute of Epidemiology (EPI), Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Neuherberg, Germany.
    Vermeulen, Roel
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
    Peters, Annette
    Institute of Epidemiology (EPI), Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Neuherberg, Germany; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany; Munich Heart Alliance, German Center for Cardiovascular Health (DZHK e.V., partner-site Munich), Munich, Germany.
    Ljungman, Petter
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden.
    Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe2023Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 179, artikkel-id 108136Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: The complex interplay of multiple environmental factors and cardiovascular has scarcely been studied. Within the EXPANSE project, we evaluated the association between long-term exposure to multiple environmental indices and stroke incidence across Europe.

    Methods: Participants from three traditional adult cohorts (Germany, Netherlands and Sweden) and four administrative cohorts (Catalonia [region Spain], Rome [city-wide], Greece and Sweden [nationwide]) were followed until incident stroke, death, migration, loss of follow-up or study end. We estimated exposures at residential addresses from different exposure domains: air pollution (nitrogen dioxide (NO2), particulate matter < 2.5 μm (PM2.5), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) and meteorology (seasonal mean and standard deviation of temperatures). Associations between environmental exposures and stroke were estimated in single and multiple-exposure Cox proportional hazard models, and Principal Component (PC) Analyses derived prototypes for specific exposures domains. We carried out random effects meta-analyses by cohort type.

    Results: In over 15 million participants, increased levels of NO2 and BC were associated with increased higher stroke incidence in both cohort types. Increased Normalized Difference Vegetation Index (NDVI) was associated with a lower stroke incidence in both cohort types, whereas an increase in impervious surface was associated with an increase in stroke incidence. The first PC of the air pollution domain (PM2.5, NO2 and BC) was associated with an increase in stroke incidence. For the built environment, higher levels of NDVI and lower levels of impervious surfaces were associated with a protective effect [%change in HR per 1 unit = −2.0 (95 %CI, −5.9;2.0) and −1.1(95 %CI, −2.0; −0.3) for traditional adult and administrative cohorts, respectively]. No clear patterns were observed for distance to blue spaces or temperature parameters.

    Conclusions: We observed increased HRs for stroke with exposure to PM2.5, NO2 and BC, lower levels of greenness and higher impervious surface in single and combined exposure models.

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  • 9. de' Donato, Francesca K.
    et al.
    Leone, Michela
    Scortichini, Matteo
    De Sario, Manuela
    Katsouyanni, Klea
    Lanki, Timo
    Basagaña, Xavier
    Ballester, Ferran
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Paldy, Anna
    Pascal, Mathilde
    Gasparrini, Antonio
    Menne, Bettina
    Michelozzi, Paola
    Changes in the effect of heat on mortality in the last 20 years in nine European cities: results from the PHASE project2015Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 12, nr 12, s. 15567-15583Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The European project PHASE aims to evaluate patterns of change in the temperature–mortality relationship and in the number of deaths attributable to heat in nine European cities in two periods, before and after summer 2003 (1996–2002 and 2004–2010). We performed age-specific Poisson regression models separately in the two periods, controlling for seasonality, air pollution and time trends. Distributed lag non-linear models were used to estimate the Relative Risks of daily mortality for increases in mean temperature from the 75th to 99th percentile of the summer distribution for each city. In the recent period, a reduction in the mortality risk associated to heat was observed only in Athens, Rome and Paris, especially among the elderly. Furthermore, in terms of heat-attributable mortality, 985, 787 and 623 fewer deaths were estimated, respectively, in the three cities. In Helsinki and Stockholm, there is a suggestion of increased heat effect. Noteworthy is that an effect of heat was still present in the recent years in all cities, ranging from +11% to +35%. In Europe, considering the warming observed in recent decades and population ageing, effective intervention measures should be promoted across countries, especially targeting vulnerable subgroups of the population with lower adaptive resources.

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  • 10.
    Domingo, Nina G.G.
    et al.
    Department of Environmental Health Sciences, Yale School of Public Health, CT, New Haven, United States; Yale Center on Climate Change and Health, Yale School of Public Health, CT, New Haven, United States.
    Fiore, Arlene M.
    Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, MA, Cambridge, United States.
    Lamarque, Jean-Francois
    Climate and Global Dynamics Laboratory, National Center for Atmospheric Research, CO, Boulder, United States.
    Kinney, Patrick L.
    Department of Environmental Health, School of Public Health, Boston University, MA, Boston, United States.
    Jiang, Leiwen
    Asian Demographic Research Institute, Shanghai University, Shanghai, China; Population Council, NY, New York, United States.
    Gasparrini, Antonio
    Environment & Health Modelling (EHM) Lab, Department of Public Health Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Breitner, Susanne
    IBE-Chair of Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.
    Lavigne, Eric
    School of Epidemiology & Public Health, Faculty of Medicine, University of Ottawa, ON, Ottawa, Canada; Environmental Health and Science Bureau, Heatlh Canada, ON, Ottawa, Canada.
    Madureira, Joana
    Environmental Health Department of the National Health Institute of Health Dr. Ricardo Jorge, Porto, Portugal; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, Portugal.
    Masselot, Pierre
    Department of Public Health Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Silva, Susana das Neves Pereira da
    Environmental Health Department of the National Health Institute of Health Dr. Ricardo Jorge, Porto, Portugal.
    Sheng Ng, Chris Fook
    Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
    Kyselý, Jan
    Institute of Atmospheric Physics, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic.
    Guo, Yuming
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, NSW, Melbourne, Australia; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, NSW, Melbourne, Australia.
    Tong, Shilu
    School of Public Health and Social Work, Queensland University of Technology, QLD, Brisbane, Australia; School of Public Health and Institute of Environment and Human Health, Anhui Medical University, Hefei, China; Shanghai Children's Medical Centre, Shanghai Jiao-Tong University, Shanghai, China.
    Kan, Haidong
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
    Urban, Aleš
    Institute of Atmospheric Physics, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic.
    Orru, Hans
    Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Maasikmets, Marek
    Estonian Environmental Research Centre, Tallinn, Estonia.
    Pascal, Mathilde
    Santé Publique France, Department of Environmental Health, French National Public Health Agency, Saint Maurice, France.
    Katsouyanni, Klea
    Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece; Environmental Research Group, School of Public Health, Imperial College London, London, United Kingdom.
    Samoli, Evangelia
    Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece.
    Scortichini, Matteo
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
    Stafoggia, Massimo
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
    Hashizume, Masahiro
    Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Alahmad, Barrak
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States.
    Diaz, Magali Hurtado
    Department of Environmental Health, National Institute of Public Health, Morelos, Cuernavaca, Mexico.
    De la Cruz Valencia, César
    Department of Environmental Health, National Institute of Public Health, Morelos, Cuernavaca, Mexico.
    Scovronick, Noah
    Department of Environmental Health, Rollins School of Public Health, Emory University, GA, Atlanta, United States.
    Garland, Rebecca M.
    Department of Geography, Geoinformatics and Meteorology, University of Pretoria, Pretoria, South Africa.
    Kim, Ho
    Graduate School of Public Health, Seoul National University, Seoul, South Korea.
    Lee, Whanhee
    Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea; Institute of Ewha-SCL for Environmental Health (IESEH), Seoul, South Korea.
    Tobias, Aurelio
    School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain.
    Íñiguez, Carmen
    Department of Statistics and Computational Research, Universitat de València, València, Spain; Ciberesp, Madrid, Spain.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Ragettli, Martina S.
    Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
    Guo, Yue Leon
    Environmental and Occupational Medicine, National Taiwan University (NTU) College of Medicine and NTU Hospital, Taipei, Taiwan.
    Pan, Shih-Chun
    National Institute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan.
    Colistro, Valentina
    The Centre on Climate Change and Planetary Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Department of Quantitative Methods, School of Medicine, University of the Republic, Montevideo, Uruguay.
    Bell, Michelle
    School of the Environment, Yale University, CT, New Haven, United States.
    Zanobetti, Antonella
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States.
    Schwartz, Joel
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States.
    Schneider, Alexandra
    Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany.
    Vicedo-Cabrera, Ana M.
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Oeschger Center for Climate Change Research, University of Bern, Bern, Switzerland.
    Chen, Kai
    Department of Environmental Health Sciences, Yale School of Public Health, CT, New Haven, United States; Yale Center on Climate Change and Health, Yale School of Public Health, CT, New Haven, United States.
    Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement2024Inngår i: One Earth, ISSN 2590-3330, E-ISSN 2590-3322, Vol. 7, nr 2, s. 325-335Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Short-term exposure to ground-level ozone in cities is associated with increased mortality and is expected to worsen with climate and emission changes. However, no study has yet comprehensively assessed future ozone-related acute mortality across diverse geographic areas, various climate scenarios, and using CMIP6 multi-model ensembles, limiting our knowledge on future changes in global ozone-related acute mortality and our ability to design targeted health policies. Here, we combine CMIP6 simulations and epidemiological data from 406 cities in 20 countries or regions. We find that ozone-related deaths in 406 cities will increase by 45 to 6,200 deaths/year between 2010 and 2014 and between 2050 and 2054, with attributable fractions increasing in all climate scenarios (from 0.17% to 0.22% total deaths), except the single scenario consistent with the Paris Climate Agreement (declines from 0.17% to 0.15% total deaths). These findings stress the need for more stringent air quality regulations, as current standards in many countries are inadequate.

  • 11.
    Ebi, Kristie L.
    et al.
    Department of Global Health, University of Washington, in Seattle, Washington..
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Boyer, Christopher J.
    Harrington, Luke J.
    Hess, Jeremy J.
    Honda, Yasushi
    Kazura, Eileen
    Stuart-Smith, Rupert F.
    Otto, Friederike E. L.
    Using Detection And Attribution To Quantify How Climate Change Is Affecting Health2020Inngår i: Health Affairs, ISSN 0278-2715, E-ISSN 1544-5208, Vol. 39, nr 12, s. 2168-2174Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The question of whether, how, and to what extent climate change is affecting health is central to many climate and health studies. We describe a set of formal methods, termed detection and attribution, used by climatologists to determine whether a climate trend or extreme event has changed and to estimate the extent to which climate change influenced that change. We discuss events where changing weather patterns were attributed to climate change and extend these analyses to include health impacts from heat waves in 2018 and 2019 in Europe and Japan, and we show how such impact attribution could be applied to melting ice roads in the Arctic. Documenting the causal chain from emissions of greenhouse gases to observed human health outcomes is important input into risk assessments that prioritize health system preparedness and response interventions and into financial investments and communication about potential risk to policy makers and to the public.

  • 12. Lee, Jae Young
    et al.
    Kim, Ho
    Gasparrini, Antonio
    Armstrong, Ben
    Bell, Michelle L
    Sera, Francesco
    Lavigne, Eric
    Abrutzky, Rosana
    Tong, Shilu
    Coelho, Micheline de Sousa Zanotti Stagliorio
    Saldiva, Paulo Hilario Nascimento
    Correa, Patricia Matus
    Ortega, Nicolas Valdes
    Kan, Haidong
    Garcia, Samuel Osorio
    Kyselý, Jan
    Urban, Aleš
    Orru, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa. Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Indermitte, Ene
    Jaakkola, Jouni J K
    Ryti, Niilo R I
    Pascal, Mathilde
    Goodman, Patrick G
    Zeka, Ariana
    Michelozzi, Paola
    Scortichini, Matteo
    Hashizume, Masahiro
    Honda, Yasushi
    Hurtado, Magali
    Cruz, Julio
    Seposo, Xerxes
    Nunes, Baltazar
    Teixeira, João Paulo
    Tobias, Aurelio
    Íñiguez, Carmen
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Vicedo-Cabrera, Ana Maria
    Ragettli, Martina S
    Guo, Yue-Liang Leon
    Chen, Bing-Yu
    Zanobetti, Antonella
    Schwartz, Joel
    Dang, Tran Ngoc
    Do Van, Dung
    Mayvaneh, Fetemeh
    Overcenco, Ala
    Li, Shanshan
    Guo, Yuming
    Predicted temperature-increase-induced global health burden and its regional variability2019Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 131, artikkel-id 105027Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    An increase in the global health burden of temperature was projected for 459 locations in 28 countries worldwide under four representative concentration pathway scenarios until 2099. We determined that the amount of temperature increase for each 100 ppm increase in global CO2 concentrations is nearly constant, regardless of climate scenarios. The overall average temperature increase during 2010-2099 is largest in Canada (1.16 °C/100 ppm) and Finland (1.14 °C/100 ppm), while it is smallest in Ireland (0.62 °C/100 ppm) and Argentina (0.63 °C/100 ppm). In addition, for each 1 °C temperature increase, the amount of excess mortality is increased largely in tropical countries such as Vietnam (10.34%p/°C) and the Philippines (8.18%p/°C), while it is decreased in Ireland (-0.92%p/°C) and Australia (-0.32%p/°C). To understand the regional variability in temperature increase and mortality, we performed a regression-based modeling. We observed that the projected temperature increase is highly correlated with daily temperature range at the location and vulnerability to temperature increase is affected by health expenditure, and proportions of obese and elderly population.

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  • 13. Liu, Cong
    et al.
    Cai, Jing
    Chen, Renjie
    Sera, Francesco
    Guo, Yuming
    Tong, Shilu
    Li, Shanshan
    Lavigne, Eric
    Correa, Patricia Matus
    Ortega, Nicolas Valdes
    Orru, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa. Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Maasikmets, Marek
    Jaakkola, Jouni J.K.
    Ryti, Niilo
    Breitner, Susanne
    Schneider, Alexandra
    Katsouyanni, Klea
    Samoli, Evangelina
    Hashizume, Masahiro
    Honda, Yasushi
    Ng, Chris Fook Sheng
    Diaz, Magali Hurtado
    Valencia, César De la Cruz
    Rao, Shilpa
    Palomares, Alfonso Diz-Lois
    Silva, Susana Pereira da
    Madureira, Joana
    Holobâc, Iulian Horia
    Fratianni, Simona
    Scovronick, Noah
    Garland, Rebecca M.
    Tobias, Aurelio
    Íñiguez, Carmen
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Vicedo-Cabrera, Ana Maria
    Ragettli, Martina S.
    Guo, Yue-Liang Leon
    Pan, Shih-Chun
    Milojevic, Ai
    Bell, Michelle L.
    Zanobetti, Antonella
    Schwartz, Joel
    Gasparrini, Antonio
    Kan, Haidong
    Coarse particulate air pollution and daily mortality: a global study in 205 cities2022Inngår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 206, nr 8, s. 999-1007Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    RATIONALE: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality is not fully understood at a global scale.

    OBJECTIVES: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide.

    METHODS: We collected daily mortality (total, cardiovascular, respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine particulate matter. A two-stage time-series analytic approach was applied, with over-dispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from co-pollutants (fine particulate matter, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled and regional analyses were conducted.

    MEASUREMENTS AND MAIN RESULTS: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI]: 0.18%, 0.84%), 0.43% (95%CI: 0.15%, 0.71%) and 0.41% (95%CI: 0.06%, 0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all co-pollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds.

    CONCLUSIONS: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.

  • 14. Liu, Cong
    et al.
    Chen, Renjie
    Sera, Francesco
    Vicedo-Cabrera, Ana M
    Guo, Yuming
    Tong, Shilu
    Coelho, Micheline S Z S
    Saldiva, Paulo H N
    Lavigne, Eric
    Matus, Patricia
    Valdes Ortega, Nicolas
    Osorio Garcia, Samuel
    Pascal, Mathilde
    Stafoggia, Massimo
    Scortichini, Matteo
    Hashizume, Masahiro
    Honda, Yasushi
    Hurtado-Díaz, Magali
    Cruz, Julio
    Nunes, Baltazar
    Teixeira, João P
    Kim, Ho
    Tobias, Aurelio
    Íñiguez, Carmen
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Ragettli, Martina S
    Guo, Yue-Leon
    Chen, Bing-Yu
    Bell, Michelle L
    Wright, Caradee Y
    Scovronick, Noah
    Garland, Rebecca M
    Milojevic, Ai
    Kyselý, Jan
    Urban, Aleš
    Orru, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa. The Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Indermitte, Ene
    Jaakkola, Jouni J K
    Ryti, Niilo R I
    Katsouyanni, Klea
    Analitis, Antonis
    Zanobetti, Antonella
    Schwartz, Joel
    Chen, Jianmin
    Wu, Tangchun
    Cohen, Aaron
    Gasparrini, Antonio
    Kan, Haidong
    Ambient Particulate Air Pollution and Daily Mortality in 652 Cities2019Inngår i: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 381, nr 8, s. 705-715Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias.

    METHODS: We evaluated the associations of inhalable particulate matter (PM) with an aerodynamic diameter of 10 μm or less (PM10) and fine PM with an aerodynamic diameter of 2.5 μm or less (PM2.5) with daily all-cause, cardiovascular, and respiratory mortality across multiple countries or regions. Daily data on mortality and air pollution were collected from 652 cities in 24 countries or regions. We used overdispersed generalized additive models with random-effects meta-analysis to investigate the associations. Two-pollutant models were fitted to test the robustness of the associations. Concentration-response curves from each city were pooled to allow global estimates to be derived.

    RESULTS: On average, an increase of 10 μg per cubic meter in the 2-day moving average of PM10 concentration, which represents the average over the current and previous day, was associated with increases of 0.44% (95% confidence interval [CI], 0.39 to 0.50) in daily all-cause mortality, 0.36% (95% CI, 0.30 to 0.43) in daily cardiovascular mortality, and 0.47% (95% CI, 0.35 to 0.58) in daily respiratory mortality. The corresponding increases in daily mortality for the same change in PM2.5 concentration were 0.68% (95% CI, 0.59 to 0.77), 0.55% (95% CI, 0.45 to 0.66), and 0.74% (95% CI, 0.53 to 0.95). These associations remained significant after adjustment for gaseous pollutants. Associations were stronger in locations with lower annual mean PM concentrations and higher annual mean temperatures. The pooled concentration-response curves showed a consistent increase in daily mortality with increasing PM concentration, with steeper slopes at lower PM concentrations.

    CONCLUSIONS: Our data show independent associations between short-term exposure to PM10 and PM2.5 and daily all-cause, cardiovascular, and respiratory mortality in more than 600 cities across the globe. These data reinforce the evidence of a link between mortality and PM concentration established in regional and local studies. (Funded by the National Natural Science Foundation of China and others.).

  • 15. Masselot, Pierre
    et al.
    Sera, Francesco
    Schneider, Rochelle
    Kan, Haidong
    Lavigne, Éric
    Stafoggia, Massimo
    Tobias, Aurelio
    Chen, Hong
    Burnett, Richard T.
    Schwartz, Joel
    Zanobetti, Antonella
    Bell, Michelle L.
    Chen, Bing-Yu
    Leon Guo, Yue-Liang
    Ragettli, Martina S.
    Vicedo-Cabrera, Ana Maria
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Íñiguez, Carmen
    Garland, Rebecca M.
    Scovronick, Noah
    Madureira, Joana
    Nunes, Baltazar
    De la Cruz Valencia, César
    Hurtado Diaz, Magali
    Honda, Yasushi
    Hashizume, Masahiro
    Fook Cheng Ng, Chris
    Samoli, Evangelia
    Katsouyanni, Klea
    Schneider, Alexandra
    Breitner, Susanne
    Ryti, Niilo R. I.
    Jaakkola, Jouni J. K.
    Maasikmets, Marek
    Orru, Hans
    Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Guo, Yuming
    Valdés Ortega, Nicolás
    Matus Correa, Patricia
    Tong, Shilu
    Gasparrini, Antonio
    Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study2022Inngår i: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 33, nr 2, s. 167-175Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality.

    METHODS: We applied a two-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as well as meta-predictors derived from city-specific socio-economic and environmental indicators.

    RESULTS: We found associations between RR and several PM2.5 components. Increasing the ammonium (NH4+) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95%CI: 1.0030-1.0097) to 1.0102 (95%CI:1.0070-1.0135). Conversely, an increase in nitrate (NO3-) from 1% to 71% resulted in a reduced RR, from 1.0100 (95%CI: 1.0067-1.0133) to 1.0037 (95%CI: 0.9998- 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM2.5 risk.

    CONCLUSIONS: These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM2.5 components and sources given the overlapping sources and correlations among many components.

  • 16. Meng, Xia
    et al.
    Liu, Cong
    Chen, Renjie
    Sera, Francesco
    Vicedo-Cabrera, Ana Maria
    Milojevic, Ai
    Guo, Yuming
    Tong, Shilu
    Coelho, Micheline de Sousa Zanotti Stagliorio
    Saldiva, Paulo Hilario Nascimento
    Lavigne, Eric
    Correa, Patricia Matus
    Ortega, Nicolas Valdes
    Osorio Garcia, Samuel
    Kyselý, Jan
    Urban, Aleš
    Orru, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa. Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Maasikmets, Marek
    Jaakkola, Jouni J. K.
    Ryti, Niilo
    Huber, Veronika
    Schneider, Alexandra
    Katsouyanni, Klea
    Analitis, Antonis
    Hashizume, Masahiro
    Honda, Yasushi
    Ng, Chris Fook Sheng
    Nunes, Baltazar
    Teixeira, João Paulo
    Holobaca, Iulian Horia
    Fratianni, Simona
    Kim, Ho
    Tobias, Aurelio
    Íñiguez, Carmen
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Ragettli, Martina S.
    Guo, Yue-Liang Leon
    Pan, Shih-Chun
    Li, Shanshan
    Bell, Michelle L.
    Zanobetti, Antonella
    Schwartz, Joel
    Wu, Tangchun
    Gasparrini, Antonio
    Kan, Haidong
    Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities.2021Inngår i: The BMJ, E-ISSN 1756-1833, Vol. 372, artikkel-id n534Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: To evaluate the short term associations between nitrogen dioxide (NO2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol.

    DESIGN: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis.

    SETTING: 398 cities in 22 low to high income countries/regions.

    MAIN OUTCOME MEASURES: Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018.

    RESULTS: On average, a 10 μg/m3 increase in NO2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM10 and PM2.5, respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities.

    CONCLUSIONS: This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO2.

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  • 17.
    Olstrup, Henrik
    et al.
    Atmospheric Science Unit, Department of Environmental Science and Analytical Chemistry, Stockholm University, 11418 Stockholm, Sweden..
    Johansson, Christer
    Atmospheric Science Unit, Department of Environmental Science and Analytical Chemistry, Stockholm University, 11418 Stockholm, Sweden. Environment and Health Administration, SLB, Box 8136, 104 20 Stockholm, Sweden..
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Association between Mortality and Short-Term Exposure to Particles, Ozone and Nitrogen Dioxide in Stockholm, Sweden2019Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 16, nr 6, artikkel-id E1028Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study, the effects on daily mortality in Stockholm associated with short-term exposure to ultrafine particles (measured as number of particles with a diameter larger than 4 nm, PNC₄), black carbon (BC) and coarse particles (PM2.5⁻10) have been compared with the effects from more common traffic-pollution indicators (PM10, PM2.5 and NO₂) and O₃ during the period 2000⁻2016. Air pollution exposure was estimated from measurements at a 20 m high building in central Stockholm. The associations between daily mortality lagged up to two days (lag 02) and the different air pollutants were modelled by using Poisson regression. The pollutants with the strongest indications of an independent effect on daily mortality were O₃, PM2.5⁻10 and PM10. In the single-pollutant model, an interquartile range (IQR) increase in O₃ was associated with an increase in daily mortality of 2.0% (95% CI: 1.1⁻3.0) for lag 01 and 1.9% (95% CI: 1.0⁻2.9) for lag 02. An IQR increase in PM2.5⁻10 was associated with an increase in daily mortality of 0.8% (95% CI: 0.1⁻1.5) for lag 01 and 1.1% (95% CI: 0.4⁻1.8) for lag 02. PM10 was associated with a significant increase only at lag 02, with 0.8% (95% CI: 0.08⁻1.4) increase in daily mortality associated with an IQR increase in the concentration. NO₂ exhibits negative associations with mortality. The significant excess risk associated with O₃ remained significant in two-pollutant models after adjustments for PM2.5⁻10, BC and NO₂. The significant excess risk associated with PM2.5⁻10 remained significant in a two-pollutant model after adjustment for NO₂. The significantly negative associations for NO₂ remained significant in two-pollutant models after adjustments for PM2.5⁻10, O₃ and BC. A potential reason for these findings, where statistically significant excess risks were found for O₃, PM2.5⁻10 and PM10, but not for NO₂, PM2.5, PNC₄ and BC, is behavioral factors that lead to misclassification in the exposure. The concentrations of O₃ and PM2.5⁻10 are in general highest during sunny and dry days during the spring, when exposure to outdoor air tend to increase, while the opposite applies to NO₂, PNC₄ and BC, with the highest concentrations during the short winter days with cold weather, when people are less exposed to outdoor air.

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  • 18.
    Olstrup, Henrik
    et al.
    Institute of Family Medicine and Public Health, Faculty of Medicine, University of Tartu, Ravila 19, Tartu, Estonia.
    Johansson, Christer
    Atmospheric Science Unit, Department of Environmental Science, Stockholm University, Stockholm, Sweden; Environment and Health Administration, SLB-analys, Box 8136, Stockholm, Sweden.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Orru, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Seasonal variations in the daily mortality associated with exposure to particles, nitrogen dioxide, and ozone in stockholm, sweden, from 2000 to 20162021Inngår i: Atmosphere, E-ISSN 2073-4433, Vol. 12, nr 11, artikkel-id 1481Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Urban air pollutant emissions and concentrations vary throughout the year due to various factors, e.g., meteorological conditions and human activities. In this study, seasonal variations in daily mortality associated with increases in the concentrations of PM10 (particulate matter), PM2.5–10 (coarse particles), BC (black carbon), NO2 (nitrogen dioxide), and O3 (ozone) were calculated for Stockholm during the period from 2000 to 2016. The excess risks in daily mortality are presented in single and multi-pollutant models during the whole year and divided into four different seasons, i.e., winter (December–February), spring (March–May), summer (June–August), and autumn (September–November). The excess risks in the single-pollutant models associated with an interquartile range (IQR) increase for a lag 02 during the whole year were 0.8% (95% CI: 0.1–1.4) for PM10, 1.1% (95% CI: 0.4–1.8) for PM2.5–10, 0.5% (95% CI: −0.5–1.5) for BC, −1.5% (95% CI: −0.5–−2.5) for NO2, and 1.9% (95% CI: 1.0–2.9) for O3. When divided into different seasons, the excess risks for PM10 and PM2.5–10 showed a clear pattern, with the strongest associations during spring and autumn, but with weaker associations during summer and winter, indicating increased risks associated with road dust particles during these seasons. For BC, which represents combustion-generated particles, the pattern was not very clear, but the strongest positive excess risks were found during autumn. The excess risks for NO2 were negative during all seasons, and in several cases even statistically significantly negative, indicating that NO2 in itself was not harmful at the concentrations prevailing during the measurement period (mean values < 20 µg m−3). For O3, the excess risks were statistically significantly positive during “all year” in both the single and the multi-pollutant models. The excess risks for O3 in the single-pollutant models were also statistically significantly positive during all seasons.

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  • 19.
    Olstrup, Henrik
    et al.
    Institute of Family Medicine and Public Health, Faculty of Medicine, University of Tartu, Ravila 19, Tartu, Estonia.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Orru, Hans
    Institute of Family Medicine and Public Health, Faculty of Medicine, University of Tartu, Ravila 19, Tartu, Estonia.
    Daily Mortality in Different Age Groups Associated with Exposure to Particles, Nitrogen Dioxide and Ozone in Two Northern European Capitals: Stockholm and Tallinn2022Inngår i: Environments, E-ISSN 2076-3298, Vol. 9, nr 7, artikkel-id 83Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Although the association between air pollution and mortality is well established, less is known about the effects in different age groups. This study analyzes the short-term associations between mortality in different age groups (0–14 years of age, 15–64 years of age, and 65+ years of age) and a number of air pollutants in two relatively clean northern European capitals: Stockholm and Tallinn. The concentrations in PM10 (particles with an aerodynamic diameter smaller than or equal to 10 µm), PM2.5–10 (coarse particles), PM2.5 (particles with an aerodynamic diameter smaller than or equal to 2.5 µm), BC (black carbon), PNC4 (particle number count of particles larger than or equal to 4 nm), NO2 (nitrogen dioxide), and O3 (ozone) were measured during the period of 2000–2016 in Stockholm and 2001–2018 in Tallinn (except for BC and PNC4 which were only measured in Stockholm). The excess risks in daily mortality associated with an interquartile range (IQR) increase in the measured air pollutants were calculated in both single- and multi-pollutant models for lag01 and lag02 (average concentration during the same and the previous day, and the same and the previous two days, respectively) using a quasi-Poisson regression model with a logistic link function. In general, the calculated excess risks per IQR increase were highest in the age group 0–14 years of age in both Stockholm and Tallinn. However, in Stockholm, a statistically significant effect was shown for PM2.5–10, and in Tallinn for O3. In the oldest age group (65+), statistically significant effects were shown for both PM2.5–10, PM10, and O3 in Stockholm, and for O3 in Tallinn.

    Fulltekst (pdf)
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  • 20.
    Orru, Hans
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Andersson, Camilla
    Swedish Meteorological and Hydrological Institute, Norrköping, Sweden.
    Ebi, Kristie L
    ClimAdapt, Los Altos, California, USA.
    Langner, Joakim
    Swedish Meteorological and Hydrological Institute, Norrköping, Sweden.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Impact of climate change on ozone-related mortality and morbidity in Europe2013Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 41, nr 2, s. 285-294Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Ozone is a highly oxidative pollutant formed from precursors in the presence of sunlight, associated with respiratory morbidity and mortality. All else being equal, concentrations of ground-level ozone are expected to increase due to climate change.Ozone-related health impacts under a changing climate are projected using emission scenarios, models and epidemiological data. European ozone concentrations are modelled with MATCH-RCA3 (50×50 km). Projections from two climate models, ECHAM4 and HadCM3, are applied, under greenhouse gas emission scenarios A2 and A1B respectively. We apply a European-wide exposure-response function to gridded population data and country-specific baseline mortality and morbidity.Comparing the current situation (1990-2009) with the baseline period (1961-1990), the largest increase in ozone-associated mortality and morbidity due to climate change (4-5%) have occurred in Belgium, Ireland, Netherlands and UK. Comparing the baseline period and the future periods (2021-2050 and 2041-2060), much larger increase in ozone-related mortality and morbidity are projected for Belgium, France, Spain and Portugal with the impact being stronger using the climate projection from ECHAM4 (A2). However, in Nordic and Baltic countries the same magnitude of decrease is projected.The current study suggests that projected effects of climate change on ozone concentrations could differentially influence mortality and morbidity across Europe.

  • 21.
    Orru, Hans
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa. Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Andersson, Camilla
    Tamm, Tanel
    Ebi, Kristie L.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Ozone and heat-related mortality in Europe in 2050 significantly affected by changes in climate, population and greenhouse gas emission2019Inngår i: Environmental Research Letters, E-ISSN 1748-9326, Vol. 14, nr 7, artikkel-id 074013Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Climate change is expected to increase to extreme temperatures and lead to more intense formation of near-surface ozone. Higher temperatures can cause heat stress and ozone is a highly oxidative pollutant; both increase cardiorespiratory mortality. Using greenhouse gas and ozone precursor emission scenarios, global and regional climate and chemistry-transport models, epidemiological data, and population projections, we projected ozone- and heat-related health risks under a changing climate. European near-surface temperature was modelled with the regional climate model (RCA4), forced by the greenhouse gas emission scenario RCP4.5 and the global climate model EC-EARTH, and near-surface ozone was modelled with the Multi-scale Atmospheric Transport and Chemistry (MATCH) model. Two periods were compared: recent climate in 1991-2000 and future climate in 2046-2055, projecting around a 2 degrees increase in global temperatures by that time. Projections of premature mortality considered future climate, future population, and future emissions separately and jointly to understand the relative importance of their contributions. Ozone currently causes 55 000 premature deaths annually in Europe due to long-term exposure, including a proportion of the estimated 26 000 deaths per year due to short-term exposures. When only taking into account the impact of a changing climate, up to an 11% increase in ozone-associated mortality is expected in some countries in Central and Southern Europe in 2050. However, projected decreases in ozone precursor emissions are expected to result in a decrease in ozone-related mortality (-30% as EUaverage). Due to aging and increasingly susceptible populations, the decrease in 2050 would be smaller, up to -24%. During summer months, ozone risks could combine with increasing temperatures, especially during the hottest periods and in densely populated urban areas. While the heat burden is currently of the same order of magnitude as ozone, due to increasing temperatures and decreasing ozone precursor emissions, heat-related mortality could be twice as large as ozone-related mortality in 2050.

    Fulltekst (pdf)
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  • 22.
    Oudin Åström, Daniel
    et al.
    Center for Primary Health Care Research, Department of Clinical Sciences, Malmö, Lund University, Lund.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Vicedo-Cabrera, Ana M.
    Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, UK.
    Gasparrini, Antonio
    Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, UK.
    Oudin, Anna
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Occupational and Environmental Medicine, Lund University, Sweden.
    Sundquist, Kristina
    Center for Primary Health Care Research, Department of Clinical Sciences, Malmö, Lund University, Lund.
    Heat wave-related mortality in Sweden: a case-crossover study investigating effect modification by neighbourhood deprivation2020Inngår i: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 48, nr 4, s. 428-435Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    AIMS: The present study aimed to investigate if set thresholds in the Swedish heat-wave warning system are valid for all parts of Sweden and if the heat-wave warning system captures a potential increase in all-cause mortality and coronary heart disease (CHD) mortality. An additional aim was to investigate whether neighbourhood deprivation modifies the relationship between heat waves and mortality.

    METHODS: From 1990 until 2014, in 14 municipalities in Sweden, we collected data on daily maximum temperatures and mortality for the five warmest months. Heat waves were defined according to the categories used in the current Swedish heat-wave warning system. Using a case-crossover approach, we investigated the association between heat waves and mortality in Sweden, as well as a modifying effect of neighbourhood deprivation.

    RESULTS: On a national as well as a regional level, heat waves significantly increased both all-cause mortality and CHD mortality by approximately 10% and 15%, respectively. While neighbourhood deprivation did not seem to modify heat wave-related all-cause mortality, CHD mortality did seem to modify the risk.

    CONCLUSIONS: It may not be appropriate to assume that heat waves in Sweden will have the same impact in a northern setting as in a southern, or that the impact of heat waves will be the same in affluent and deprived neighbourhoods. When designing and implementing heat-wave warning systems, neighbourhood, regional and national information should be incorporated.

  • 23.
    Oudin Åström, Daniel
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia; Centre for Primary Health Care Research, Department of Clinical Science, Malmö, Lund University, Lund, Sweden.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Rekker, Kaidi
    Indermitte, Ene
    Orru, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    High Summer Temperatures and Mortality in Estonia2016Inngår i: PLOS ONE, E-ISSN 1932-6203, Vol. 11, nr 5, artikkel-id e0155045Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: On-going climate change is predicted to result in a growing number of extreme weather events-such as heat waves-throughout Europe. The effect of high temperatures and heat waves are already having an important impact on public health in terms of increased mortality, but studies from an Estonian setting are almost entirely missing. We investigated mortality in relation to high summer temperatures and the time course of mortality in a coastal and inland region of Estonia.

    METHODS: We collected daily mortality data and daily maximum temperature for a coastal and an inland region of Estonia. We applied a distributed lag non-linear model to investigate heat related mortality and the time course of mortality in Estonia.

    RESULTS: We found an immediate increase in mortality associated with temperatures exceeding the 75th percentile of summer maximum temperatures, corresponding to approximately 23°C. This increase lasted for a couple of days in both regions. The total effect of elevated temperatures was not lessened by significant mortality displacement.

    DISCUSSION: We observed significantly increased mortality in Estonia, both on a country level as well as for a coastal region and an inland region with a more continental climate. Heat related mortality was higher in the inland region as compared to the coastal region, however, no statistically significant differences were observed. The lower risks in coastal areas could be due to lower maximum temperatures and cooling effects of the sea, but also better socioeconomic condition. Our results suggest that region specific estimates of the impacts of temperature extremes on mortality are needed.

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  • 24.
    Rai, Masna
    et al.
    Institute of Epidemiology, Helmholtz Munich, - German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology – IBE, Pettenkofer School of Public Health, LMU Munich, Munich, Germany.
    Stafoggia, Massimo
    Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy.
    de'Donato, Francesca
    Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy.
    Scortichini, Matteo
    Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy.
    Zafeiratou, Sofia
    epartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Greece.
    Vazquez Fernandez, Liliana
    Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
    Zhang, Siqi
    Institute of Epidemiology, Helmholtz Munich, - German Research Center for Environmental Health, Neuherberg, Germany.
    Katsouyanni, Klea
    epartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Greece.
    Samoli, Evangelia
    epartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Greece.
    Rao, Shilpa
    Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
    Lavigne, Eric
    School of Epidemiology & Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada and Environmental Health Science & Research Bureau, Health Canada, Ottawa, Canada.
    Guo, Yuming
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
    Kan, Haidong
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
    Osorio, Samuel
    Department of Environmental Health, University of São Paulo, São Paulo, Brazil.
    Kyselý, Jan
    Institute of Atmospheric Physics, Czech Academy of Sciences, Prague, Czech Republic Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic.
    Urban, Aleš
    Institute of Atmospheric Physics, Czech Academy of Sciences, Prague, Czech Republic Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic.
    Orru, Hans
    Department of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
    Maasikmets, Marek
    Estonian Environmental Research Centre, Tallinn, Estonia.
    Jaakkola, Jouni J.K.
    Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland.
    Ryti, Niilo
    Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland.
    Pascal, Mathilde
    Santé Publique France, Department of Environmental Health, French National Public Health Agency, Saint Maurice, France.
    Hashizume, Masahiro
    Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Fook Sheng Ng, Chris
    School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
    Alahmad, Barrak
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, MA, Boston, United States.
    Hurtado Diaz, Magali
    Department of Environmental Health, National Institute of Public Health, Morelos, Cuernavaca, Mexico.
    De la Cruz Valencia, César
    Department of Environmental Health, National Institute of Public Health, Morelos, Cuernavaca, Mexico.
    Nunes, Baltazar
    Department of Environmental Health, Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto, Portugal.
    Madureira, Joana
    Department of Environmental Health, Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto, Portugal.
    Scovronick, Noah
    Department of Environmental Health. Rollins School of Public Health, Emory University, Atlanta, United States.
    Garland, Rebecca M.
    Department of Geography, Geoinformatics and Meteorology, University of Pretoria, Pretoria, South Africa.
    Kim, Ho
    Graduate School of Public Health, Seoul National University, Seoul, South Korea.
    Lee, Whanhee
    School of Biomedical Convergence Engineering, Pusan National University, Yangsan, South Korea.
    Tobias, Aurelio
    Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain.
    Íñiguez, Carmen
    Department of Statistics and Computational Research, Universitat de València, València, Spain.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Maria Vicedo-Cabrera, Ana
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
    Ragettli, Martina S.
    Swiss Tropical and Public Health Institute, Basel, Switzerland.
    Leon Guo, Yue-Liang
    Environmental and Occupational Medicine, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University (NTU) and NTU Hospital, Taipei, Taiwan.
    Pan, Shih-Chun
    National Institute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan.
    Li, Shanshan
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
    Gasparrini, Antonio
    Department of Public Health Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Sera, Francesco
    Department of Statistics, Computer Science and Applications “G. Parenti”, University of Florence, Florence, Italy.
    Masselot, Pierre
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
    Schwartz, Joel
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, MA, Boston, United States.
    Zanobetti, Antonella
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, MA, Boston, United States.
    Bell, Michelle L.
    School of Forestry and Environmental Studies, Yale University, CT, New Haven, United States.
    Schneider, Alexandra
    Institute of Epidemiology, Helmholtz Munich, - German Research Center for Environmental Health, Neuherberg, Germany.
    Breitner, Susanne
    Institute of Epidemiology, Helmholtz Munich, - German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology – IBE, Pettenkofer School of Public Health, LMU Munich, Munich, Germany.
    Heat-related cardiorespiratory mortality: effect modification by air pollution across 482 cities from 24 countries2023Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 174, artikkel-id 107825Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries.

    Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model.

    Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively.

    Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.

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  • 25.
    Saucy, Apolline
    et al.
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Coloma, Fabián
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Olmos, Sergio
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Blay, Natalia
    Genomes for Life-GCAT Lab, German Trias i Pujol Research Institute (IGTP), Badalona, Spain.
    Boer, Jolanda M.A.
    National Institute for Public Health and the Environment, Bilthoven, Netherlands.
    Dadvand, Payam
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    de Bont, Jeroen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    de Cid, Rafael
    Genomes for Life-GCAT Lab, German Trias i Pujol Research Institute (IGTP), Badalona, Spain.
    de Hoogh, Kees
    Swiss Tropical and Public Health Institute Basel, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
    Dimakopoulou, Konstantina
    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    Gehring, Ulrike
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
    Huss, Anke
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
    Ibi, Dorina
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
    Katsouyanni, Klea
    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
    Koppelman, Gerard
    Department of Pediatric Pulmonology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands.
    Ljungman, Petter
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden.
    Melén, Erik
    Department of Clinical Sciences and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Sachś Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
    Nieuwenhuijsen, Mark
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Nobile, Federica
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.
    Peters, Annette
    Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; IBE, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
    Pickford, Regina
    Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
    Vermeulen, Roel
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
    Vienneau, Danielle
    Swiss Tropical and Public Health Institute Basel, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
    Vlaanderen, Jelle
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
    Wolf, Kathrin
    Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
    Yu, Zhebin
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Samoli, Evangelia
    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    Stafoggia, Massimo
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.
    Tonne, Cathryn
    ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
    Socioeconomic inequalities in the external exposome in European cohorts: the EXPANSE project2024Inngår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.

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  • 26. Scortichini, Matteo
    et al.
    de'Donato, Francesca
    De Sario, Manuela
    Leone, Michela
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Ballester, Ferran
    Basagaña, Xavier
    Bobvos, Janos
    Gasparrini, Antonio
    Katsouyanni, Klea
    Lanki, Timo
    Menne, Bettina
    Pascal, Mathilde
    Michelozzi, Paola
    The inter-annual variability of heat-related mortality in nine European cities (1990–2010)2018Inngår i: Environmental Health, E-ISSN 1476-069X, Vol. 17, nr 1, artikkel-id 66Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The association between heat and daily mortality and its temporal variation are well known. However, few studies have analyzed the inter-annual variations in both the risk estimates and impacts of heat. The aim is to estimate inter-annual variations in the effect of heat for a fixed temperature range, on mortality in 9 European cities included in the PHASE (Public Health Adaptation Strategies to Extreme weather events) project for the period 1990-2010. The second aim is to evaluate overall summer effects and heat-attributable deaths for each year included in the study period, considering the entire air temperature range (both mild and extreme temperatures).

    METHODS: A city-specific daily time-series analysis was performed, using a generalized additive Poisson regression model, restricted to the warm season (April-September). To study the temporal variation for a fixed air temperature range, a Bayesian Change Point analysis was applied to the relative risks of mortality for a 2 °C increase over the 90th percentile of the city-specific distribution. The number of heat attributable deaths in each summer were also calculated for mild (reference to 95th percentile) and extreme heat (95th percentile to maximum value).

    RESULTS: A decline in the effects of heat over time was observed in Athens and Rome when considering a fixed interval, while an increase in effects was observed in Helsinki. The greatest impact of heat in terms of attributable deaths was observed in the Mediterranean cities (Athens, Barcelona and Rome) for extreme air temperatures. In the other cities the impact was mostly related to extreme years with 2003 as a record breaking year in Paris (+ 1900 deaths) and London (+ 1200 deaths).

    CONCLUSIONS: Monitoring the impact of heat over time is important to identify changes in population vulnerability and evaluate adaptation measures.

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  • 27. Sera, Francesco
    et al.
    Armstrong, Ben
    Tobias, Aurelio
    Vicedo-Cabrera, Ana Maria
    Åström, Christofer
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Bell, Michelle L
    Chen, Bing-Yu
    de Sousa Zanotti Stagliorio Coelho, Micheline
    Matus Correa, Patricia
    Cruz, Julio Cesar
    Dang, Tran Ngoc
    Hurtado-Diaz, Magali
    Do Van, Dung
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.
    Guo, Yue Leon
    Guo, Yuming
    Hashizume, Masahiro
    Honda, Yasushi
    Iñiguez, Carmen
    Jaakkola, Jouni J K
    Kan, Haidong
    Kim, Ho
    Lavigne, Eric
    Michelozzi, Paola
    Ortega, Nicolas Valdes
    Osorio, Samuel
    Pascal, Mathilde
    Ragettli, Martina S
    Ryti, Niilo R I
    Saldiva, Paulo Hilario Nascimento
    Schwartz, Joel
    Scortichini, Matteo
    Seposo, Xerxes
    Tong, Shilu
    Zanobetti, Antonella