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  • 1.
    Arslan, Alan A
    et al.
    Department of Environmental Medicine, New York University School of Medicine.
    Clendenen, Tess V
    Department of Environmental Medicine, New York University School of Medicine.
    Koenig, Karen L
    Department of Environmental Medicine, New York University School of Medicine.
    Hultdin, Johan
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
    Enquist, Kerstin
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Lukanova, Annekatrin
    Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
    Sjodin, Hubert
    Umeå University, Faculty of Medicine, Department of Medical Biosciences.
    Zeleniuch-Jacquotte, Anne
    Department of Environmental Medicine, New York University School of Medicine.
    Shore, Roy E
    Radiation Effects Research Foundation, Hiroshima, Japan.
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Toniolo, Paolo
    Department of Environmental Medicine, New York University School of Medicine.
    Lundin, Eva
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Circulating vitamin d and risk of epithelial ovarian cancer2009In: Journal of oncology, ISSN 1687-8450, Vol. 2009, p. 672492-672500Article in journal (Refereed)
    Abstract [en]

    We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59-2.01). In addition, there was no evidence of an interaction effect between VDR SNP genotype or haplotype and circulating 25(OH)D levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.

  • 2.
    Berglin, Eva
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
    Kokkonen, Heidi
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
    Einarsdottir, E
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Rantapää Dahlqvist, Solbritt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
    Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study2010In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, Vol. 39, no 6, p. 454-460Article in journal (Refereed)
    Abstract [en]

    A longer duration of breastfeeding increased the risk of developing RA, especially among individuals seropositive for ACPA or IgM-RF or carrying the PTPN22 1858T variant. Use of OC for ≥ 7 years was associated with a decreased risk.

  • 3. Bjerregaard, Bine Kjøller
    et al.
    Raaschou-Nielsen, Ole
    Sørensen, Mette
    Frederiksen, Kirsten
    Tjønneland, Anne
    Rohrmann, Sabine
    Linseisen, Jakob
    Bergman, Manuela M
    Boeing, Heiner
    Sieri, Sabina
    Palli, Domenico
    Tumino, Rosario
    Sacerdote, Carlotta
    Bueno-de-Mesquita, H Bas
    Büchner, Frederike L
    Gram, Inger Torhild
    Braaten, Tonje
    Lund, Eiliv
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Riboli, Elio
    The effect of occasional smoking on smoking-related cancers: in the European Prospective Investigation into Cancer and Nutrition (EPIC).2006In: Cancer Causes Control, ISSN 0957-5243, Vol. 17, no 10, p. 1305-9Article in journal (Refereed)
  • 4.
    Einarsdottir, Elisabet
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics. Medicinsk och klinisk genetik.
    Mayans, Sofia
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics. Medicinsk och klinisk genetik.
    Ruikka, Karin
    Andersson Escher, Stefan
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics. Medicinsk och klinisk genetik.
    Lindgren, Petter
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics. Medicinsk och klinisk genetik.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Näringsforskning.
    Eliasson, Mats
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Holmberg, Dan
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics. Medicinsk och klinisk genetik.
    Linkage but not association of calpain-10 to type 2 diabetes replicated in northern Sweden2006In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 55, no 6, p. 1879-1883Article in journal (Refereed)
  • 5. Freisling, Heinz
    et al.
    Fahey, Michael T
    Moskal, Aurelie
    Ocké, Marga C
    Ferrari, Pietro
    Jenab, Mazda
    Norat, Teresa
    Naska, Androniki
    Welch, Ailsa A
    Navarro, Carmen
    Schulz, Mandy
    Wirfält, Elisabet
    Casagrande, Corinne
    Amiano, Pilar
    Ardanaz, Eva
    Parr, Christine
    Engeset, Dagrun
    Grioni, Sara
    Sera, Francesco
    Bueno-de-Mesquita, Bas
    van der Schouw, Yvonne T
    Touvier, Mathilde
    Boutron-Ruault, Marie-Christine
    Halkjaer, Jytte
    Dahm, Christina C
    Khaw, Kay-Tee
    Crowe, Francesca
    Linseisen, Jakob
    Kröger, Janine
    Huybrechts, Inge
    Deharveng, Geneviève
    Manjer, Jonas
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Trichopoulou, Antonia
    Tsiotas, Kostas
    Riboli, Elio
    Bingham, Sheila
    Slimani, Nadia
    Region-specific nutrient intake patterns exhibit a geographical gradient within and between European countries.2010In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 140, no 7, p. 1280-6Article in journal (Refereed)
    Abstract [en]

    Until recently, the study of nutrient patterns was hampered at an international level by a lack of standardization of both dietary methods and nutrient databases. We aimed to describe the diversity of nutrient patterns in the European Prospective Investigation into Cancer and Nutrition (EPIC) study at population level as a starting point for future nutrient pattern analyses and their associations with chronic diseases in multi-center studies. In this cross-sectional study, 36,034 persons aged 35-74 y were administered a single, standardized 24-h dietary recall. Intake of 25 nutrients (excluding intake from dietary supplements) was estimated using a standardized nutrient database. We used a graphic presentation of mean nutrient intakes by region and sex relative to the overall EPIC means to contrast patterns within and between 10 European countries. In Mediterranean regions, including Greece, Italy, and the southern centers of Spain, the nutrient pattern was dominated by relatively high intakes of vitamin E and monounsaturated fatty acids (MUFA), whereas intakes of retinol and vitamin D were relatively low. In contrast, in Nordic countries, including Norway, Sweden, and Denmark, reported intake of these same nutrients resulted in almost the opposite pattern. Population groups in Germany, The Netherlands, and the UK shared a fatty acid pattern of relatively high intakes of PUFA and SFA and relatively low intakes of MUFA, in combination with a relatively high intake of sugar. We confirmed large variability in nutrient intakes across the EPIC study populations and identified 3 main region-specific patterns with a geographical gradient within and between European countries.

  • 6. Hampe, C S
    et al.
    Hall, T R
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine. Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Nutritional Research.
    Rolandsson, Olov
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Family Medicine. Allmänmedicin.
    Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes.2007In: Clin Exp Immunol, ISSN 0009-9104, Vol. 148, no 1, p. 72-8Article in journal (Refereed)
  • 7. Khan, Aneire E
    et al.
    Gallo, Valentina
    Linseisen, Jakob
    Kaaks, Rudolf
    Rohrmann, Sabine
    Raaschou-Nielsen, Ole
    Tjønneland, Anne
    Johnsen, Hans E
    Overvad, Kim
    Bergmann, Manuela M
    Boeing, Heiner
    Benetou, Vasiliki
    Psaltopoulou, Theodora
    Trichopoulou, Antonia
    Masala, Giovanna
    Mattiello, Amalia
    Grioni, Sara
    Tumino, Rosario
    Vermeulen, Roel C H
    Peeters, Petra H M
    Bueno-de-Mesquita, H Bas
    Ros, Martine M
    Lund, Eiliv
    Ardanaz, Eva
    Chirlaque, María-Dolores
    Jakszyn, Paula
    Larrañaga, Nerea
    Losada, Adamina
    Becker, Nikolaus
    Nieters, Alexandra
    Martínez-García, Carmen
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Biobank Research.
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Berglund, Göran
    Manjer, Jonas
    Allen, Naomi E
    Key, Timothy J
    Bingham, Sheila
    Khaw, Kay Tee
    Slimani, Nadia
    Ferrari, Pietro
    Boffetta, Paolo
    Norat, Teresa
    Vineis, Paolo
    Riboli, Elio
    Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European prospective investigation into Cancer and nutrition2008In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 93, no 6, p. 842-850Article in journal (Refereed)
  • 8.
    Kröger, J
    et al.
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
    Ferrari, P
    Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
    Jenab, M
    Lifestyle and Cancer Group, International Agency for Research on Cancer, Lyon, France.
    Bamia, C
    Department of Hygiene, Epidemiology and Medical Statistics, University of Athens, Medical School, Athens, Greece.
    Touvier, M
    Inserm, ERI 20, Institut Gustave Roussy, Villejuif, France.
    Bueno-de-Mesquita, H B
    National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
    Fahey, M T
    Biostatistics Unit, Medical Research Council and University of Cambridge, Cambridge, UK.
    Benetou, V
    Department of Hygiene, Epidemiology and Medical Statistics, University of Athens, Medical School, Athens, Greece.
    Schulz, M
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
    Wirfält, E
    Department of Clinical Sciences, Lund University, Malmö, Sweden.
    Boeing, H
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
    Hoffmann, K
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
    Schulze, M B
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
    Orfanos, P
    Department of Hygiene, Epidemiology and Medical Statistics, University of Athens, Medical School, Athens, Greece.
    Oikonomou, E
    Department of Hygiene, Epidemiology and Medical Statistics, University of Athens, Medical School, Athens, Greece.
    Huybrechts, I
    Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
    Rohrmann, S
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
    Pischon, T
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
    Manjer, J
    Department of Surgery, Malmö University Hospital, Malmö, Sweden.
    Ågren, Å
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Navarro, C
    Epidemiology Department, Murcia Health Council, Murcia and CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
    Jakszyn, P
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.
    Boutron-Ruault, M C
    Inserm, ERI 20, Institut Gustave Roussy, Villejuif, France.
    Niravong, M
    Inserm, ERI 20, Institut Gustave Roussy, Villejuif, France.
    Khaw, K T
    University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Cambridge, UK.
    Crowe, F
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK.
    Ocké, M C
    National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
    van der Schouw, Y T
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
    Mattiello, A
    Department of Clinical and Experimental Medicine, University of Naples, Federico II, Naples, Italy.
    Bellegotti, M
    Nutritional Epidemiology Unit, Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
    Engeset, D
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway.
    Hjartåker, A
    Cancer Registry of Norway, Oslo, Norway.
    Egeberg, R
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
    Overvad, K
    Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
    Riboli, E
    Department of Epidemiology, Public Health and Primary Care, Imperial College, London, UK.
    Bingham, S
    Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK.
    Slimani, N
    Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
    Specific food group combinations explaining the variation in intakes of nutrients and other important food components in the European prospective investigation into cancer and nutrition: an application of the reduced rank regression method2009In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 63 Suppl 4, p. S263-S274Article in journal (Refereed)
    Abstract [en]

    A combination of food groups was identified that explained a considerable proportion of the nutrient intake variation in 24-HDRs in every country-specific EPIC population in a similar manner. This indicates that, despite the large variability in food and nutrient intakes reported in the EPIC, the variance of intake of important nutrients is explained, to a large extent, by similar food group combinations across countries.

  • 9. Kurbasic, Azra
    et al.
    Poveda, Alaitz
    Chen, Yan
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Biobank Research.
    Engberg, Elisabeth
    Umeå University, Faculty of Social Sciences, Demographic Data Base.
    Hu, Frank B
    Johansson, Ingegerd
    Umeå University, Faculty of Medicine, Department of Odontology.
    Barroso, Ines
    Brändström, Anders
    Umeå University, Faculty of Social Sciences, Demographic Data Base.
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Biobank Research. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Renström, Frida
    Umeå University, Faculty of Medicine, Department of Biobank Research.
    Franks, Paul W
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
    Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies2014In: Current nutrition reports, ISSN 2161-3311, Vol. 3, no 4, p. 400-411Article in journal (Refereed)
    Abstract [en]

    Most complex diseases have well-established genetic and non-genetic risk factors. In some instances, these risk factors are likely to interact, whereby their joint effects convey a level of risk that is either significantly more or less than the sum of these risks. Characterizing these gene-environment interactions may help elucidate the biology of complex diseases, as well as to guide strategies for their targeted prevention. In most cases, the detection of gene-environment interactions will require sample sizes in excess of those needed to detect the marginal effects of the genetic and environmental risk factors. Although many consortia have been formed, comprising multiple diverse cohorts to detect gene-environment interactions, few robust examples of such interactions have been discovered. This may be because combining data across studies, usually through meta-analysis of summary data from the contributing cohorts, is often a statistically inefficient approach for the detection of gene-environment interactions. Ideally, single, very large and well-genotyped prospective cohorts, with validated measures of environmental risk factor and disease outcomes should be used to study interactions. The presence of strong founder effects within those cohorts might further strengthen the capacity to detect novel genetic effects and gene-environment interactions. Access to accurate genealogical data would also aid in studying the diploid nature of the human genome, such as genomic imprinting (parent-of-origin effects). Here we describe two studies from northern Sweden (the GLACIER and VIKING studies) that fulfill these characteristics.

  • 10.
    Mayans, Sofia
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Lackovic, Kurt
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Lindgren, Petter
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Ruikka, Karin
    Department of Medicine, Sunderby Hospital, Luleå.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Biobank Research.
    Eliasson, Mats
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Department of Medicine, Sunderby Hospital, Luleå.
    Holmberg, Dan
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics. Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden2007In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 15, no 3, p. 342-346Article in journal (Refereed)
    Abstract [en]

    A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.

  • 11. Rinaldi, Sabina
    et al.
    Dossus, Laure
    Lukanova, Annekatrin
    Peeters, Petra H M
    Allen, Naomi E
    Key, Timothy
    Bingham, Sheila
    Khaw, Kay-Tee
    Trichopoulos, Dimitrios
    Trichopoulou, Antonia
    Oikonomou, Eleni
    Pera, Guillem
    Larrañaga, Nerea
    Martinez-Garcia, Carmen
    Ardanaz, Eva
    Quirós, J Ramón
    Tormo, María-José
    Tjønneland, Anne
    Olsen, Anja
    Overvad, Kim
    Chang-Claude, Jenny
    Linseisen, Jakob
    Schulz, Mandy
    Boeing, Heiner
    van Gils, Carla H
    Bueno-de-Mesquita, Bas H
    Pala, Valeria
    Palli, Domenico
    Panico, Salvatore
    Tumino, Rosario
    Vineis, Paolo
    Clavel-Chapelon, Françoise
    Mesrine, Sylvie
    Boutron-Ruault, Marie-Christine
    Lundin, Eva
    Umeå University, Faculty of Medicine, Medical Biosciences, Pathology. Patologi.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine. Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Nutritional Research.
    Berglund, Göran
    Manjer, Jonas
    Kumle, Merethe
    Lund, Eiliv
    Slimani, Nadia
    Saracci, Rodolfo
    Riboli, Elio
    Kaaks, Rudolf
    Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).2007In: Cancer Epidemiol Biomarkers Prev, ISSN 1055-9965, Vol. 16, no 1, p. 23-9Article in journal (Refereed)
  • 12. Rohrmann, Sabine
    et al.
    Becker, Nikolaus
    Linseisen, Jakob
    Nieters, Alexandra
    Rüdiger, Thomas
    Raaschou-Nielsen, Ole
    Tjønneland, Anne
    Johnsen, Hans E
    Overvad, Kim
    Kaaks, Rudolf
    Bergmann, Manuela M
    Boeing, Heiner
    Benetou, Vasiliki
    Psaltopoulou, Theodora
    Trichopoulou, Antonia
    Masala, Giovanna
    Mattiello, Amalia
    Krogh, Vittorio
    Tumino, Rosario
    van Gils, Carla H
    Peeters, Petra H M
    Bueno-de-Mesquita, H Bas
    Ros, Martine M
    Lund, Eiliv
    Ardanaz, Eva
    Chirlaque, María-Dolores
    Jakszyn, Paula
    Larrañaga, Nerea
    Losada, A
    Martínez-García, Carmen
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Berglund, Göran
    Manjer, Jonas
    Allen, Naomi E
    Key, Timothy J
    Bingham, Sheila
    Khaw, Kay Tee
    Slimani, Nadia
    Ferrari, Pietro
    Boffetta, Paolo
    Norat, Teresa
    Vineis, Paolo
    Riboli, Elio
    Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).2007In: Cancer Causes and Control, ISSN 0957-5243, Vol. 18, no 5, p. 537-49Article in journal (Refereed)
  • 13.
    Rolandsson, Olov
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
    Marklund, Stefan L
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
    Norberg, Margareta
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Hägg, Erik
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Hemoglobin A1c can be analyzed in blood kept frozen at -80 degrees C and is not commonly affected by hemolysis in the general population.2004In: Metabolism, ISSN 0026-0495, Vol. 53, no 11, p. 1496-9Article in journal (Refereed)
  • 14.
    Söderberg, Stefan
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
    Stegmayr, Birgitta
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Stenlund, Hans
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Sjöström, L-G
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Johansson, L
    Weinehall, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Olsson, Tommy
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Leptin, but not adiponectin, predicts stroke in males.2004In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 256, no 2, p. 128-136Article in journal (Refereed)
  • 15.
    Tedeschi, Rosamaria
    et al.
    Microbiology-Immunology and Virology Department, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
    Bidoli, Ettore
    Epidemiology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
    Ågren, Åsa
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Wadell, Göran
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    De Paoli, Paolo
    Microbiology-Immunology and Virology Department, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
    Dillner, Joakim
    Department of Laboratory Medicine, Lund University, MAS University Hospital, Malmö, Sweden.
    Epidemiology of Kaposi's sarcoma herpesvirus (HHV8) in Västerbotten county, Sweden.2006In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 78, no 3, p. 372-378Article in journal (Refereed)
    Abstract [en]

    A population-based serosurvey of Human Herpesvirus type 8 (HHV8) in Västerbotten county, an area of Northern Sweden with high incidence of Kaposi's Sarcoma, was conducted. Serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against HHV8, using a sensitive indirect immunofluorescence assay to latent and lytic HHV8 antigens. Buffy coat DNA was also analyzed for viral DNA using real time PCR assay. HHV8 DNA was not detectable in any one of the buffy coat samples. Eighty-four subjects (16.2%) were HHV8 seropositive, 14.4% for the lytic HHV8 antigen, and 1.7% for the latent HHV8 antigen. HHV8 seroprevalences were not associated significantly with sex or age. HHV8 seropositivity was more common among smokers (OR: 1.95, 95% CI: 1.02–3.75), but was less common among consumers of wine and spirits (OR: 0.44, 95% CI: 0.25–0.77 and OR: 0.50, 95% CI: 0.26–0.95, respectively). In summary, HHV8 has an intermediate high and stable seroprevalence rate in Northern Sweden, but environmental determinants that can explain the viral distribution were not found. J. Med. Virol. 78:372–378, 2006. © 2006 Wiley-Liss, Inc.

     

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