Umeå universitets logga

umu.sePublikationer
Ändra sökning
Avgränsa sökresultatet
1 - 3 av 3
RefereraExporteraLänk till träfflistan
Permanent länk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Träffar per sida
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Författare A-Ö
  • Författare Ö-A
  • Titel A-Ö
  • Titel Ö-A
  • Publikationstyp A-Ö
  • Publikationstyp Ö-A
  • Äldst först
  • Nyast först
  • Skapad (Äldst först)
  • Skapad (Nyast först)
  • Senast uppdaterad (Äldst först)
  • Senast uppdaterad (Nyast först)
  • Disputationsdatum (tidigaste först)
  • Disputationsdatum (senaste först)
  • Standard (Relevans)
  • Författare A-Ö
  • Författare Ö-A
  • Titel A-Ö
  • Titel Ö-A
  • Publikationstyp A-Ö
  • Publikationstyp Ö-A
  • Äldst först
  • Nyast först
  • Skapad (Äldst först)
  • Skapad (Nyast först)
  • Senast uppdaterad (Äldst först)
  • Senast uppdaterad (Nyast först)
  • Disputationsdatum (tidigaste först)
  • Disputationsdatum (senaste först)
Markera
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 1.
    Gaifas, Lorenzo
    et al.
    Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
    Kirchner, Moritz A.
    Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
    Timmins, Joanna
    Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
    Gutsche, Irina
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
    Blik is an extensible 3D visualisation tool for the annotation and analysis of cryo-electron tomography data2024Ingår i: PLoS biology, ISSN 1544-9173, E-ISSN 1545-7885, Vol. 22, nr 4, artikel-id e3002447Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Powerful workflow-agnostic and interactive visualisation is essential for the ad hoc, human-in-the-loop workflows typical of cryo-electron tomography (cryo-ET). While several tools exist for visualisation and annotation of cryo-ET data, they are often integrated as part of monolithic processing pipelines, or focused on a specific task and offering limited reusability and extensibility. With each software suite presenting its own pros and cons and tools tailored to address specific challenges, seamless integration between available pipelines is often a difficult task. As part of the effort to enable such flexibility and move the software ecosystem towards a more collaborative and modular approach, we developed blik, an open-source napari plugin for visualisation and annotation of cryo-ET data (source code: https://github.com/brisvag/blik). blik offers fast, interactive, and user-friendly 3D visualisation thanks to napari, and is built with extensibility and modularity at the core. Data is handled and exposed through well-established scientific Python libraries such as numpy arrays and pandas dataframes. Reusable components (such as data structures, file read/write, and annotation tools) are developed as independent Python libraries to encourage reuse and community contribution. By easily integrating with established image analysis tools-even outside of the cryo-ET world-blik provides a versatile platform for interacting with cryoET data. On top of core visualisation features-interactive and simultaneous visualisation of tomograms, particle picks, and segmentations-blik provides an interface for interactive tools such as manual, surface-based and filament-based particle picking, and image segmentation, as well as simple filtering tools. Additional self-contained napari plugins developed as part of this work also implement interactive plotting and selection based on particle features, and label interpolation for easier segmentation. Finally, we highlight the differences with existing software and showcase blik's applicability in biological research.

    Ladda ner fulltext (pdf)
    fulltext
  • 2.
    Gutsche, Irina
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Institut de Biologie Structurale, Univ Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
    Montelione, Gaetano T.
    Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, NY, Troy, United States.
    Editorial overview: Biophysical methods: Multiple structures of proteins underpin their biological functions2024Ingår i: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 84, artikel-id 102762Artikel i tidskrift (Övrigt vetenskapligt)
  • 3.
    McGregor, Lindsay
    et al.
    Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France.
    Acajjaoui, Samira
    Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France.
    Desfosses, Ambroise
    Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS (IBS), Grenoble, France.
    Saïdi, Melissa
    Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France.
    Bacia-Verloop, Maria
    Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS (IBS), Grenoble, France.
    Schwarz, Jennifer J.
    European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
    Juyoux, Pauline
    European Molecular Biology Laboratory (EMBL), Grenoble, France.
    von Velsen, Jill
    European Molecular Biology Laboratory (EMBL), Grenoble, France.
    Bowler, Matthew W.
    European Molecular Biology Laboratory (EMBL), Grenoble, France.
    McCarthy, Andrew A.
    European Molecular Biology Laboratory (EMBL), Grenoble, France.
    Kandiah, Eaazhisai
    Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France.
    Gutsche, Irina
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS (IBS), Grenoble, France.
    Soler-Lopez, Montserrat
    Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France.
    The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination2023Ingår i: Nature Communications, E-ISSN 2041-1723, Vol. 14, nr 1, artikel-id 8248Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathogenesis, is poorly understood. Here we report the structural basis of the complex formation between the MCIA subunits ECSIT and ACAD9. ECSIT binding induces a major conformational change in the FAD-binding loop of ACAD9, releasing the FAD cofactor and converting ACAD9 from a fatty acid β-oxidation (FAO) enzyme to a CI assembly factor. We provide evidence that ECSIT phosphorylation downregulates its association with ACAD9 and is reduced in neuronal cells upon exposure to amyloid-β (Aβ) oligomers. These findings advance our understanding of the MCIA complex assembly and suggest a possible role for ECSIT in the reprogramming of bioenergetic pathways linked to Aβ toxicity, a hallmark of AD.

    Ladda ner fulltext (pdf)
    fulltext
1 - 3 av 3
RefereraExporteraLänk till träfflistan
Permanent länk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf