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  • 1.
    Wang, Tianxiao
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Li, Menghong
    Umeå University, Faculty of Medicine, Department of Odontology.
    Gu, Ziyan
    Umeå University, Faculty of Medicine, Department of Odontology.
    Qu, Chengjuan
    Umeå University, Faculty of Medicine, Department of Odontology.
    Segervald, Jonas
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Salh, Roushdey
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Wågberg, Thomas
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Wang, Jia
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Kou, Wen
    Umeå University, Faculty of Medicine, Department of Odontology.
    Fluoride releasing in polymerblends of poly(ethylene oxide) and poly(methyl methacrylate)2024In: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 12, article id 1356029Article in journal (Refereed)
    Abstract [en]

    Introduction: Polymethyl methacrylate is a polymer commonly used in clinicaldentistry, including denture bases, occlusal splints and orthodontic retainers.

    Methods: To augment the polymethyl methacrylate-based dental appliances incounteracting dental caries, we designed a polymer blend film composed ofpolymethyl methacrylate and polyethylene oxide by solution casting and addedsodium fluoride.

    Results: Polyethylene oxide facilitated the dispersion of sodium fluoride,decreased the surface average roughness, and positively influenced thehydrophilicity of the films. The blend film made of polymethyl methacrylate,polyethylene oxide and NaF with a mass ratio of 10: 1: 0.3 showed sustainedrelease of fluoride ions and acceptable cytotoxicity. Antibacterial activity of all thefilms to Streptococcus mutans was negligible.

    Discussion: This study demonstrated that the polymer blends of polyethyleneoxide and polymethyl methacrylate could realize the relatively steady release offluoride ions with high biocompatibility. This strategy has promising potential toendow dental appliances with anti-cariogenicity.

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